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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41949

FusionGeneSummary for WDSUB1_GPD2

check button Fusion gene summary
Fusion gene informationFusion gene name: WDSUB1_GPD2
Fusion gene ID: 41949
HgeneTgene
Gene symbol

WDSUB1

GPD2

Gene ID

151525

2820

Gene nameWD repeat, sterile alpha motif and U-box domain containing 1glycerol-3-phosphate dehydrogenase 2
SynonymsUBOX6|WDSAM1GDH2|GPDM|mGPDH
Cytomap

2q24.2

2q24.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat, SAM and U-box domain-containing protein 1glycerol-3-phosphate dehydrogenase, mitochondrialGPD-MGPDH-Mglycerol-3-phosphate dehydrogenase 2 (mitochondrial)mitochondrial glycerophosphate dehydrogenasemtGPDtesticular tissue protein Li 76
Modification date2018051920180519
UniProtAcc

Q8N9V3

P43304

Ensembl transtripts involved in fusion geneENST00000359774, ENST00000358147, 
ENST00000392796, ENST00000409990, 
ENST00000409124, 		ENST00000310454, 
ENST00000409125, ENST00000438166, 
ENST00000540309, ENST00000409674, 
ENST00000496190, 
Fusion gene scores* DoF score4 X 3 X 4=483 X 2 X 3=18
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDSUB1 [Title/Abstract] AND GPD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-G2-A3VY-01AWDSUB1chr2

160104883

-GPD2chr2

157332610

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000359774ENST00000310454WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000359774ENST00000409125WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000359774ENST00000438166WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000359774ENST00000540309WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000359774ENST00000409674WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-intronENST00000359774ENST00000496190WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000358147ENST00000310454WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000358147ENST00000409125WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000358147ENST00000438166WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000358147ENST00000540309WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000358147ENST00000409674WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-intronENST00000358147ENST00000496190WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000392796ENST00000310454WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000392796ENST00000409125WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000392796ENST00000438166WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000392796ENST00000540309WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000392796ENST00000409674WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-intronENST00000392796ENST00000496190WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000409990ENST00000310454WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000409990ENST00000409125WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000409990ENST00000438166WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000409990ENST00000540309WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-5UTRENST00000409990ENST00000409674WDSUB1chr2

160104883

-GPD2chr2

157332610

+
5CDS-intronENST00000409990ENST00000496190WDSUB1chr2

160104883

-GPD2chr2

157332610

+
intron-5UTRENST00000409124ENST00000310454WDSUB1chr2

160104883

-GPD2chr2

157332610

+
intron-5UTRENST00000409124ENST00000409125WDSUB1chr2

160104883

-GPD2chr2

157332610

+
intron-5UTRENST00000409124ENST00000438166WDSUB1chr2

160104883

-GPD2chr2

157332610

+
intron-5UTRENST00000409124ENST00000540309WDSUB1chr2

160104883

-GPD2chr2

157332610

+
intron-5UTRENST00000409124ENST00000409674WDSUB1chr2

160104883

-GPD2chr2

157332610

+
intron-intronENST00000409124ENST00000496190WDSUB1chr2

160104883

-GPD2chr2

157332610

+

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FusionProtFeatures for WDSUB1_GPD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDSUB1

Q8N9V3

GPD2

P43304


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDSUB1_GPD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDSUB1_GPD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDSUB1FBXO25GPD2FAF2, PARK2, CUL7, HAX1, NUFIP1, SLC8A3, TRAPPC10, SLC39A4, WDFY2, NTRK1, ACO2, SDHB, UQCRQ, COX2, NF2, DUPD1, GDPD5, SLC39A8, PVR, C12orf74, TMEM206, PCDHGB1, HDAC10, NPY2R


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDSUB1_GPD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDSUB1_GPD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGPD2C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneGPD2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneGPD2C0029456Osteoporosis1CTD_human
TgeneGPD2C0268583Methylmalonic acidemia1CTD_human