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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41946

FusionGeneSummary for WDR90_RAB40C

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR90_RAB40C
Fusion gene ID: 41946
HgeneTgene
Gene symbol

WDR90

RAB40C

Gene ID

197335

57799

Gene nameWD repeat domain 90RAB40C, member RAS oncogene family
SynonymsC16orf15|C16orf16|C16orf17|C16orf18|C16orf19RARL|RASL8C
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 90ras-related protein Rab-40CRAR (RAS like GTPASE) likeRAR likeRAS-like GTPaseRAS-like, family 8, member CSOCS box-containing protein RAR3rar-like proteinras-like protein family member 8C
Modification date2018051920180523
UniProtAcc

Q96KV7

Q96S21

Ensembl transtripts involved in fusion geneENST00000549091, ENST00000293879, 
ENST00000547543, ENST00000547944, 
ENST00000315764, 
ENST00000535977, 
ENST00000539661, ENST00000538492, 
ENST00000248139, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 3=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR90 [Title/Abstract] AND RAB40C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-49-6744-01AWDR90chr16

712059

+RAB40Cchr16

667208

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000549091ENST00000535977WDR90chr16

712059

+RAB40Cchr16

667208

+
In-frameENST00000549091ENST00000539661WDR90chr16

712059

+RAB40Cchr16

667208

+
In-frameENST00000549091ENST00000538492WDR90chr16

712059

+RAB40Cchr16

667208

+
In-frameENST00000549091ENST00000248139WDR90chr16

712059

+RAB40Cchr16

667208

+
In-frameENST00000293879ENST00000535977WDR90chr16

712059

+RAB40Cchr16

667208

+
In-frameENST00000293879ENST00000539661WDR90chr16

712059

+RAB40Cchr16

667208

+
In-frameENST00000293879ENST00000538492WDR90chr16

712059

+RAB40Cchr16

667208

+
In-frameENST00000293879ENST00000248139WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547543ENST00000535977WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547543ENST00000539661WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547543ENST00000538492WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547543ENST00000248139WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547944ENST00000535977WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547944ENST00000539661WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547944ENST00000538492WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000547944ENST00000248139WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000315764ENST00000535977WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000315764ENST00000539661WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000315764ENST00000538492WDR90chr16

712059

+RAB40Cchr16

667208

+
intron-3CDSENST00000315764ENST00000248139WDR90chr16

712059

+RAB40Cchr16

667208

+

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FusionProtFeatures for WDR90_RAB40C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR90

Q96KV7

RAB40C

Q96S21

Probable substrate-recognition component of a SCF-likeECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000269|PubMed:15601820}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411156_120113441749RepeatNote=WD 12
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411204_124513441749RepeatNote=WD 13
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411247_128613441749RepeatNote=WD 14
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411298_132613441749RepeatNote=WD 15
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241407_45013441749RepeatNote=WD 1
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241452_49413441749RepeatNote=WD 2
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241501_54113441749RepeatNote=WD 3
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241615_65413441749RepeatNote=WD 4
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241656_69513441749RepeatNote=WD 5
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241698_73713441749RepeatNote=WD 6
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241740_77913441749RepeatNote=WD 7
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241782_82113441749RepeatNote=WD 8
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241882_92213441749RepeatNote=WD 9
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241926_96413441749RepeatNote=WD 10
HgeneWDR90chr16:712059chr16:667208ENST00000293879+3241969_100913441749RepeatNote=WD 11
TgeneRAB40Cchr16:712059chr16:667208ENST00000248139+06175_22847282DomainSOCS box
TgeneRAB40Cchr16:712059chr16:667208ENST00000535977+17175_22847282DomainSOCS box
TgeneRAB40Cchr16:712059chr16:667208ENST00000538492+17175_22847282DomainSOCS box
TgeneRAB40Cchr16:712059chr16:667208ENST00000539661+17175_22847282DomainSOCS box
TgeneRAB40Cchr16:712059chr16:667208ENST00000248139+06126_12947282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000248139+0669_7347282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000535977+17126_12947282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000535977+1769_7347282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000538492+17126_12947282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000538492+1769_7347282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000539661+17126_12947282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000539661+1769_7347282Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411327_137613441749RepeatNote=WD 16
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411433_147213441749RepeatNote=WD 17
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411475_152013441749RepeatNote=WD 18
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411523_156213441749RepeatNote=WD 19
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411568_161413441749RepeatNote=WD 20
HgeneWDR90chr16:712059chr16:667208ENST00000293879+32411715_174813441749RepeatNote=WD 21
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161156_1201-105300RepeatNote=WD 12
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161204_1245-105300RepeatNote=WD 13
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161247_1286-105300RepeatNote=WD 14
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161298_1326-105300RepeatNote=WD 15
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161327_1376-105300RepeatNote=WD 16
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161433_1472-105300RepeatNote=WD 17
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161475_1520-105300RepeatNote=WD 18
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161523_1562-105300RepeatNote=WD 19
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161568_1614-105300RepeatNote=WD 20
HgeneWDR90chr16:712059chr16:667208ENST00000315764+161715_1748-105300RepeatNote=WD 21
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16407_450-105300RepeatNote=WD 1
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16452_494-105300RepeatNote=WD 2
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16501_541-105300RepeatNote=WD 3
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16615_654-105300RepeatNote=WD 4
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16656_695-105300RepeatNote=WD 5
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16698_737-105300RepeatNote=WD 6
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16740_779-105300RepeatNote=WD 7
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16782_821-105300RepeatNote=WD 8
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16882_922-105300RepeatNote=WD 9
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16926_964-105300RepeatNote=WD 10
HgeneWDR90chr16:712059chr16:667208ENST00000315764+16969_1009-105300RepeatNote=WD 11
TgeneRAB40Cchr16:712059chr16:667208ENST00000248139+0621_2847282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000535977+1721_2847282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000538492+1721_2847282Nucleotide bindingGTP
TgeneRAB40Cchr16:712059chr16:667208ENST00000539661+1721_2847282Nucleotide bindingGTP


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FusionGeneSequence for WDR90_RAB40C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR90_RAB40C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR90CUL3, RBPMS, SUGT1, CLUH, DPP8, MED4, CSNK1E, OFD1, DYNLL1, CEP135, TACC3, FGFR1OP, MAPRE1, THOC2, CCDC14, FKBP5RAB40CCUL5, DCUN1D1, RNF7, TCEB2, TCEB1, RAB40C, RAB40B, RABGGTB, ANKRD27


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR90_RAB40C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR90_RAB40C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource