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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41944

FusionGeneSummary for WDR88_ZNF592

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR88_ZNF592
Fusion gene ID: 41944
HgeneTgene
Gene symbol

WDR88

ZNF592

Gene ID

126248

9640

Gene nameWD repeat domain 88zinc finger protein 592
SynonymsPQWDCAMOS|SCAR5
Cytomap

19q13.11

15q25.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 88PQQ repeat and WD repeat domain containingPQQ repeat and WD repeat-containing proteinzinc finger protein 592
Modification date2018051920180519
UniProtAcc

Q6ZMY6

Q92610

Ensembl transtripts involved in fusion geneENST00000592765, ENST00000361680, 
ENST00000355868, 
ENST00000560079, 
ENST00000299927, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR88 [Title/Abstract] AND ZNF592 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ339888WDR88chr19

33651168

-ZNF592chr15

85326519

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000592765ENST00000560079WDR88chr19

33651168

-ZNF592chr15

85326519

+
intron-3CDSENST00000592765ENST00000299927WDR88chr19

33651168

-ZNF592chr15

85326519

+
intron-3CDSENST00000361680ENST00000560079WDR88chr19

33651168

-ZNF592chr15

85326519

+
intron-3CDSENST00000361680ENST00000299927WDR88chr19

33651168

-ZNF592chr15

85326519

+
intron-3CDSENST00000355868ENST00000560079WDR88chr19

33651168

-ZNF592chr15

85326519

+
intron-3CDSENST00000355868ENST00000299927WDR88chr19

33651168

-ZNF592chr15

85326519

+

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FusionProtFeatures for WDR88_ZNF592


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR88

Q6ZMY6

ZNF592

Q92610

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR88_ZNF592


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR88_ZNF592


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR88_ZNF592


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR88_ZNF592


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZNF592C1847114SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 51CTD_human