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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41895

FusionGeneSummary for WDR70_GHR

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR70_GHR
Fusion gene ID: 41895
HgeneTgene
Gene symbol

WDR70

GHR

Gene ID

55100

2690

Gene nameWD repeat domain 70growth hormone receptor
Synonyms-GHBP|GHIP
Cytomap

5p13.2

5p13.1-p12

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 70growth hormone receptorGH receptorgrowth hormone binding proteinserum binding proteinsomatotropin receptor
Modification date2018052320180523
UniProtAcc

Q9NW82

P10912

Ensembl transtripts involved in fusion geneENST00000265107, ENST00000504564, 
ENST00000510699, 
ENST00000230882, 
ENST00000357703, ENST00000537449, 
ENST00000513625, 
Fusion gene scores* DoF score13 X 7 X 6=5465 X 3 X 4=60
# samples 135
** MAII scorelog2(13/546*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR70 [Title/Abstract] AND GHR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AC-A2FE-01AWDR70chr5

37396672

+GHRchr5

42688992

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265107ENST00000230882WDR70chr5

37396672

+GHRchr5

42688992

+
Frame-shiftENST00000265107ENST00000357703WDR70chr5

37396672

+GHRchr5

42688992

+
5CDS-intronENST00000265107ENST00000537449WDR70chr5

37396672

+GHRchr5

42688992

+
5CDS-intronENST00000265107ENST00000513625WDR70chr5

37396672

+GHRchr5

42688992

+
Frame-shiftENST00000504564ENST00000230882WDR70chr5

37396672

+GHRchr5

42688992

+
Frame-shiftENST00000504564ENST00000357703WDR70chr5

37396672

+GHRchr5

42688992

+
5CDS-intronENST00000504564ENST00000537449WDR70chr5

37396672

+GHRchr5

42688992

+
5CDS-intronENST00000504564ENST00000513625WDR70chr5

37396672

+GHRchr5

42688992

+
intron-3CDSENST00000510699ENST00000230882WDR70chr5

37396672

+GHRchr5

42688992

+
intron-3CDSENST00000510699ENST00000357703WDR70chr5

37396672

+GHRchr5

42688992

+
intron-intronENST00000510699ENST00000537449WDR70chr5

37396672

+GHRchr5

42688992

+
intron-intronENST00000510699ENST00000513625WDR70chr5

37396672

+GHRchr5

42688992

+

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FusionProtFeatures for WDR70_GHR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR70

Q9NW82

GHR

P10912

Receptor for pituitary gland growth hormone involved inregulating postnatal body growth. On ligand binding, couples tothe JAK2/STAT5 pathway (By similarity). {ECO:0000250}. The soluble form (GHBP) acts as a reservoir of growthhormone in plasma and may be a modulator/inhibitor of GHsignaling. Isoform 2 up-regulates the production of GHBP and actsas a negative inhibitor of GH signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR70_GHR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR70_GHR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR70WDR48, UBTF, ZC3H18, TSSC4, SIRT1, LMNA, RBPJ, NTRK1, SRPK2, XPO1, CHORDC1, CCT7, TCEANC2, CCT3, ARRB2, PRPF38AGHRSGTA, JAK2, CISH, SOCS1, SOCS3, SOCS2, GH1, PTPN11, SHC1, GRB2, PLCG1, GRB10, STAT3, STAT5B, JAK1, TYK2, BTRC, PTPN2, PTPRB, PTPN1, PTPRH, DUSP7, PTPN9, PTPN3, PTPN13, STUB1, SKP1, GHR, FBXW11, PIK3R2, SRPK2, NCK1, STAT5A, CUL5, NEDD8, RNF7, TCEB1, TCEB2, CUL1, FBXO31, RBX1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR70_GHR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGHRP10912DB00082PegvisomantGrowth hormone receptorbiotechapproved
TgeneGHRP10912DB00052SomatotropinGrowth hormone receptorbiotechapproved|investigational
TgeneGHRP10912DB09098SomatremGrowth hormone receptorbiotechapproved|investigational|withdrawn

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RelatedDiseases for WDR70_GHR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGHRC0271568Laron Syndrome12CTD_human;ORPHANET;UNIPROT
TgeneGHRC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneGHRC0004352Autistic Disorder1CTD_human
TgeneGHRC0033578Prostatic Neoplasms1CTD_human
TgeneGHRC0151744Myocardial Ischemia1CTD_human
TgeneGHRC1858656Short Stature, Idiopathic, Autosomal1CTD_human;ORPHANET;UNIPROT