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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41865

FusionGeneSummary for WDR55_ANKHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR55_ANKHD1
Fusion gene ID: 41865
HgeneTgene
Gene symbol

WDR55

ANKHD1

Gene ID

54853

54882

Gene nameWD repeat domain 55ankyrin repeat and KH domain containing 1
Synonyms-MASK|MASK1|PP2500|VBARP
Cytomap

5q31.3

5q31.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 55ankyrin repeat and KH domain-containing protein 1HIV-1 Vpr-binding ankyrin repeat proteinmultiple ankyrin repeats, single KH-domain homolog
Modification date2018051920180523
UniProtAcc

Q9H6Y2

Q8IWZ3

Ensembl transtripts involved in fusion geneENST00000358337, ENST00000520764, 
ENST00000360839, ENST00000297183, 
ENST00000394723, ENST00000394722, 
ENST00000462121, ENST00000544120, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 11 X 3=264
# samples 211
** MAII scorelog2(2/8*10)=1.32192809488736log2(11/264*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR55 [Title/Abstract] AND ANKHD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDREADTCGA-EI-6506-01AWDR55chr5

140052531

+ANKHD1chr5

139884404

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000358337ENST00000360839WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-3CDSENST00000358337ENST00000297183WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000358337ENST00000394723WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000358337ENST00000394722WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000358337ENST00000462121WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000358337ENST00000544120WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-3CDSENST00000520764ENST00000360839WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-3CDSENST00000520764ENST00000297183WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000520764ENST00000394723WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000520764ENST00000394722WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000520764ENST00000462121WDR55chr5

140052531

+ANKHD1chr5

139884404

+
intron-intronENST00000520764ENST00000544120WDR55chr5

140052531

+ANKHD1chr5

139884404

+

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FusionProtFeatures for WDR55_ANKHD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR55

Q9H6Y2

ANKHD1

Q8IWZ3

Nucleolar protein that acts as a modulator of rRNAsynthesis. Plays a central role during organogenesis (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR55_ANKHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR55_ANKHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR55ELAVL1, CSNK2A1, SRPK1, MOV10, NXF1, PPP4R2, CC2D2A, XPO1, FOXJ2, FOXS1, SBF1, CBWD3, MCMBP, BOP1, RPL7L1, KLHDC3, LENG8, WDR12, FTSJ3, LOC81691, RPL3, NCAPH2, PES1, JPH1, NOC3LANKHD1POLR2M, UNC93B1, SIRT7, CAND1, ATXN1, ATXN1L, VCP, NFKBIE, ZNF346, ADARB2, MOV10, NXF1, HOXC4, MAGEA1, ZC3H3, FOSL2, SFRP4, RBM23, SEC16A, CDT1, SKA3, FOS, FOXQ1, STX11, FGF8, TRIM41, FGF3, SIX2, HOXD4, IRF9, AKAP17A, ZNF263, ZNF433, IL17RA, H2AFX, NOB1, C6orf141, TULP3, CERKL, CDX1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR55_ANKHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR55_ANKHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource