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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41860

FusionGeneSummary for WDR48_WDR48

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR48_WDR48
Fusion gene ID: 41860
HgeneTgene
Gene symbol

WDR48

WDR48

Gene ID

57599

57599

Gene nameWD repeat domain 48WD repeat domain 48
SynonymsP80|SPG60|UAF1P80|SPG60|UAF1
Cytomap

3p22.2

3p22.2

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 48USP1 associated factor 1WD repeat endosomal proteintesticular tissue protein Li 224WD repeat-containing protein 48USP1 associated factor 1WD repeat endosomal proteintesticular tissue protein Li 224
Modification date2018052320180523
UniProtAcc

Q8TAF3

Q8TAF3

Ensembl transtripts involved in fusion geneENST00000302313, ENST00000418020, 
ENST00000544962, ENST00000396258, 
ENST00000466405, 
ENST00000302313, 
ENST00000418020, ENST00000544962, 
ENST00000396258, ENST00000466405, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 1=9
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR48 [Title/Abstract] AND WDR48 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWDR48

GO:0016579

protein deubiquitination

18082604|19075014|24145035

TgeneWDR48

GO:0016579

protein deubiquitination

18082604|19075014|24145035


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU675916WDR48chr3

39137401

-WDR48chr3

39137316

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000302313ENST00000302313WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-intronENST00000302313ENST00000418020WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000302313ENST00000544962WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000302313ENST00000396258WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000302313ENST00000466405WDR48chr3

39137401

-WDR48chr3

39137316

+
intron-3UTRENST00000418020ENST00000302313WDR48chr3

39137401

-WDR48chr3

39137316

+
intron-intronENST00000418020ENST00000418020WDR48chr3

39137401

-WDR48chr3

39137316

+
intron-3UTRENST00000418020ENST00000544962WDR48chr3

39137401

-WDR48chr3

39137316

+
intron-3UTRENST00000418020ENST00000396258WDR48chr3

39137401

-WDR48chr3

39137316

+
intron-3UTRENST00000418020ENST00000466405WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000544962ENST00000302313WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-intronENST00000544962ENST00000418020WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000544962ENST00000544962WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000544962ENST00000396258WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000544962ENST00000466405WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000396258ENST00000302313WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-intronENST00000396258ENST00000418020WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000396258ENST00000544962WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000396258ENST00000396258WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000396258ENST00000466405WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000466405ENST00000302313WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-intronENST00000466405ENST00000418020WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000466405ENST00000544962WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000466405ENST00000396258WDR48chr3

39137401

-WDR48chr3

39137316

+
3UTR-3UTRENST00000466405ENST00000466405WDR48chr3

39137401

-WDR48chr3

39137316

+

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FusionProtFeatures for WDR48_WDR48


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR48

Q8TAF3

WDR48

Q8TAF3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR48_WDR48


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR48_WDR48


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR48_WDR48


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR48_WDR48


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource