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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41846

FusionGeneSummary for WDR41_WDR41

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR41_WDR41
Fusion gene ID: 41846
HgeneTgene
Gene symbol

WDR41

WDR41

Gene ID

55255

55255

Gene nameWD repeat domain 41WD repeat domain 41
SynonymsMSTP048MSTP048
Cytomap

5q13.3-q14.1

5q13.3-q14.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 41WD repeat-containing protein 41
Modification date2018052220180522
UniProtAcc

Q9HAD4

Q9HAD4

Ensembl transtripts involved in fusion geneENST00000512033, ENST00000296679, 
ENST00000414719, ENST00000507029, 
ENST00000512033, ENST00000296679, 
ENST00000414719, ENST00000507029, 
Fusion gene scores* DoF score2 X 3 X 1=63 X 4 X 2=24
# samples 34
** MAII scorelog2(3/6*10)=2.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WDR41 [Title/Abstract] AND WDR41 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE089339WDR41chr5

76745585

-WDR41chr5

76759052

-
ChiTaRS3.1BE694334WDR41chr5

76759052

+WDR41chr5

76745585

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000512033ENST00000512033WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-intronENST00000512033ENST00000296679WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-5UTRENST00000512033ENST00000414719WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-5UTRENST00000512033ENST00000507029WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-intronENST00000296679ENST00000512033WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-intronENST00000296679ENST00000296679WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-5UTRENST00000296679ENST00000414719WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-5UTRENST00000296679ENST00000507029WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-intronENST00000414719ENST00000512033WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-intronENST00000414719ENST00000296679WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-5UTRENST00000414719ENST00000414719WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-5UTRENST00000414719ENST00000507029WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-intronENST00000507029ENST00000512033WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-intronENST00000507029ENST00000296679WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-5UTRENST00000507029ENST00000414719WDR41chr5

76745585

-WDR41chr5

76759052

-
5CDS-5UTRENST00000507029ENST00000507029WDR41chr5

76745585

-WDR41chr5

76759052

-
intron-intronENST00000512033ENST00000512033WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000512033ENST00000296679WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000512033ENST00000414719WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000512033ENST00000507029WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000296679ENST00000512033WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000296679ENST00000296679WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000296679ENST00000414719WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000296679ENST00000507029WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000414719ENST00000512033WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000414719ENST00000296679WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000414719ENST00000414719WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000414719ENST00000507029WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000507029ENST00000512033WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000507029ENST00000296679WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000507029ENST00000414719WDR41chr5

76759052

+WDR41chr5

76745585

+
intron-intronENST00000507029ENST00000507029WDR41chr5

76759052

+WDR41chr5

76745585

+

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FusionProtFeatures for WDR41_WDR41


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR41

Q9HAD4

WDR41

Q9HAD4

Non-catalytic component of the C9orf72-SMCR8 complex, acomplex that has guanine nucleotide exchange factor (GEF) activityand regulates autophagy (PubMed:27193190, PubMed:27103069,PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complexpromotes the exchange of GDP to GTP, converting inactive GDP-boundRAB8A and RAB39B into their active GTP-bound form, therebypromoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagyinitiation by interacting with the ATG1/ULK1 kinase complex andinhibiting its protein kinase activity (PubMed:27103069,PubMed:27617292). {ECO:0000269|PubMed:27103069,ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27617292,ECO:0000269|PubMed:28195531}. Non-catalytic component of the C9orf72-SMCR8 complex, acomplex that has guanine nucleotide exchange factor (GEF) activityand regulates autophagy (PubMed:27193190, PubMed:27103069,PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complexpromotes the exchange of GDP to GTP, converting inactive GDP-boundRAB8A and RAB39B into their active GTP-bound form, therebypromoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagyinitiation by interacting with the ATG1/ULK1 kinase complex andinhibiting its protein kinase activity (PubMed:27103069,PubMed:27617292). {ECO:0000269|PubMed:27103069,ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27617292,ECO:0000269|PubMed:28195531}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR41_WDR41


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR41_WDR41


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR41MMS19, TSPAN5, APBB2, TCTN2, NPHP1, TMEM17, TMEM216, DNAJC7, SLC27A6, MRAP2, TKTWDR41MMS19, TSPAN5, APBB2, TCTN2, NPHP1, TMEM17, TMEM216, DNAJC7, SLC27A6, MRAP2, TKT


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR41_WDR41


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR41_WDR41


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource