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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41842

FusionGeneSummary for WDR37_TUBAL3

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR37_TUBAL3
Fusion gene ID: 41842
HgeneTgene
Gene symbol

WDR37

TUBAL3

Gene ID

22884

79861

Gene nameWD repeat domain 37tubulin alpha like 3
Synonyms--
Cytomap

10p15.3

10p15.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 37tubulin alpha chain-like 3
Modification date2018052320180523
UniProtAcc

Q9Y2I8

A6NHL2

Ensembl transtripts involved in fusion geneENST00000358220, ENST00000381329, 
ENST00000263150, ENST00000482165, 
ENST00000380419, ENST00000479328, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 2 X 2=8
# samples 52
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: WDR37 [Title/Abstract] AND TUBAL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GC-A3RB-01AWDR37chr10

1132297

+TUBAL3chr10

5443050

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000358220ENST00000380419WDR37chr10

1132297

+TUBAL3chr10

5443050

-
5CDS-intronENST00000358220ENST00000479328WDR37chr10

1132297

+TUBAL3chr10

5443050

-
Frame-shiftENST00000381329ENST00000380419WDR37chr10

1132297

+TUBAL3chr10

5443050

-
5CDS-intronENST00000381329ENST00000479328WDR37chr10

1132297

+TUBAL3chr10

5443050

-
Frame-shiftENST00000263150ENST00000380419WDR37chr10

1132297

+TUBAL3chr10

5443050

-
5CDS-intronENST00000263150ENST00000479328WDR37chr10

1132297

+TUBAL3chr10

5443050

-
intron-3CDSENST00000482165ENST00000380419WDR37chr10

1132297

+TUBAL3chr10

5443050

-
intron-intronENST00000482165ENST00000479328WDR37chr10

1132297

+TUBAL3chr10

5443050

-

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FusionProtFeatures for WDR37_TUBAL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR37

Q9Y2I8

TUBAL3

A6NHL2

Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR37_TUBAL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR37_TUBAL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR37EWSR1, MOV10, NXF1, CCT3, CCT7, HSPA8, CCT6B, CCT6A, CLUH, TCP1, PACS2, PACS1, SETD2, CCDC101, LRRC46, KRAS, RBM14-RBM4, IQCF1, CCT4, CCT2, TRIM25TUBAL3SHC1, HSP90AA1, RNF2, TXNDC9, CCT7, CCT3, CCT6B, CCT6A, TCP1, CCT2, RIC8B, NPHP4, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR37_TUBAL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR37_TUBAL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource