FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4184

FusionGeneSummary for BIRC6_ABCC11

check button Fusion gene summary
Fusion gene informationFusion gene name: BIRC6_ABCC11
Fusion gene ID: 4184
HgeneTgene
Gene symbol

BIRC6

ABCC11

Gene ID

57448

85320

Gene namebaculoviral IAP repeat containing 6ATP binding cassette subfamily C member 11
SynonymsAPOLLON|BRUCEEWWD|MRP8|WW
Cytomap

2p22.3

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionbaculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollonATP-binding cassette sub-family C member 11ATP-binding cassette protein C11ATP-binding cassette transporter MRP8ATP-binding cassette transporter sub-family C member 11ATP-binding cassette, sub-family C (CFTR/MRP), member 11multi-resistance protein 8
Modification date2018052320180523
UniProtAcc

Q9NR09

Q96J66

Ensembl transtripts involved in fusion geneENST00000421745, ENST00000353782, 
ENST00000356608, ENST00000394747, 
ENST00000394748, ENST00000537808, 
ENST00000565329, 
Fusion gene scores* DoF score16 X 15 X 12=28804 X 2 X 2=16
# samples 194
** MAII scorelog2(19/2880*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BIRC6 [Title/Abstract] AND ABCC11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCC11

GO:0015711

organic anion transport

15537867|16359813

TgeneABCC11

GO:0015865

purine nucleotide transport

12764137


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LL-A7SZ-01ABIRC6chr2

32738221

+ABCC11chr16

48211024

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000421745ENST00000353782BIRC6chr2

32738221

+ABCC11chr16

48211024

-
Frame-shitENST00000421745ENST00000356608BIRC6chr2

32738221

+ABCC11chr16

48211024

-
Frame-shitENST00000421745ENST00000394747BIRC6chr2

32738221

+ABCC11chr16

48211024

-
Frame-shitENST00000421745ENST00000394748BIRC6chr2

32738221

+ABCC11chr16

48211024

-
5CDS-intronENST00000421745ENST00000537808BIRC6chr2

32738221

+ABCC11chr16

48211024

-
5CDS-5UTRENST00000421745ENST00000565329BIRC6chr2

32738221

+ABCC11chr16

48211024

-

Top

FusionProtFeatures for BIRC6_ABCC11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BIRC6

Q9NR09

ABCC11

Q96J66

Anti-apoptotic protein which can regulate cell death bycontrolling caspases and by acting as an E3 ubiquitin-proteinligase. Has an unusual ubiquitin conjugation system in that itcould combine in a single polypeptide, ubiquitin conjugating (E2)with ubiquitin ligase (E3) activity, forming a chimeric E2/E3ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Actsas an inhibitor of CASP3, CASP7 and CASP9. Important regulator forthe final stages of cytokinesis. Crucial for normal vesicletargeting to the site of abscission, but also for the integrity ofthe midbody and the midbody ring, and its striking ubiquitinmodification. {ECO:0000269|PubMed:14765125,ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}. Participates in physiological processes involving bileacids, conjugated steroids and cyclic nucleotides(PubMed:12764137, PubMed:15537867). Enhances the cellularextrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867).Stimulates the ATP-dependent uptake of a range of physiologicaland synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroidsulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) andestrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholateand taurocholate, and methotrexate (PubMed:15537867,PubMed:25896536). Probably functions to secrete earwax(PubMed:16444273, PubMed:19383836). Required for the secretion ofcomponents contributing to axillary odor formation(PubMed:19710689). {ECO:0000269|PubMed:12764137,ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273,ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689,ECO:0000269|PubMed:25896536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BIRC6_ABCC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BIRC6_ABCC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BIRC6RNF41, KIF23, USP8, DIABLO, CASP9, HTRA2, UBC, VAV2, SIRT7, CASP3, CASP7, BIRC6, CASP8, UBE2D1, CSNK2A1, RASSF2, EPS15L1, GBF1, CCNA2, CDC27, ANAPC11, TEX35, PRSS45, RTBDN, C3orf20, WDR4, DFNA5, FAM175B, CA11, FIGF, MOS, HERC2, CHIA, CLEC11A, INTS4P2, TBC1D22A, FAM58A, MCPH1, TP53, UNK, RPGR, KIF22, LLGL2, PLK1, MYH13, SSH3, AGRP, ANGPTL3, UGGT2, AKAP9, DCAF12, FERMT2, PSMC5, MGST3, CCDC22, OSBPL2, ADAMTS4, HEY1ABCC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BIRC6_ABCC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BIRC6_ABCC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource