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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41821

FusionGeneSummary for WDR25_MAST2

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR25_MAST2
Fusion gene ID: 41821
HgeneTgene
Gene symbol

WDR25

MAST2

Gene ID

79446

23139

Gene nameWD repeat domain 25microtubule associated serine/threonine kinase 2
SynonymsC14orf67MAST205|MTSSK
Cytomap

14q32.2

1p34.1

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 25microtubule-associated serine/threonine-protein kinase 2microtubule associated testis specific serine/threonine protein kinase
Modification date2018051920180523
UniProtAcc

Q64LD2

Q6P0Q8

Ensembl transtripts involved in fusion geneENST00000554998, ENST00000402312, 
ENST00000335290, ENST00000542471, 
ENST00000554175, ENST00000557502, 
ENST00000372009, ENST00000361297, 
ENST00000477968, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 8 X 8=576
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/576*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR25 [Title/Abstract] AND MAST2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-A5-A7WK-01AWDR25chr14

100848083

+MAST2chr1

46425058

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000554998ENST00000372009WDR25chr14

100848083

+MAST2chr1

46425058

+
Frame-shiftENST00000554998ENST00000361297WDR25chr14

100848083

+MAST2chr1

46425058

+
5CDS-intronENST00000554998ENST00000477968WDR25chr14

100848083

+MAST2chr1

46425058

+
Frame-shiftENST00000402312ENST00000372009WDR25chr14

100848083

+MAST2chr1

46425058

+
Frame-shiftENST00000402312ENST00000361297WDR25chr14

100848083

+MAST2chr1

46425058

+
5CDS-intronENST00000402312ENST00000477968WDR25chr14

100848083

+MAST2chr1

46425058

+
Frame-shiftENST00000335290ENST00000372009WDR25chr14

100848083

+MAST2chr1

46425058

+
Frame-shiftENST00000335290ENST00000361297WDR25chr14

100848083

+MAST2chr1

46425058

+
5CDS-intronENST00000335290ENST00000477968WDR25chr14

100848083

+MAST2chr1

46425058

+
intron-3CDSENST00000542471ENST00000372009WDR25chr14

100848083

+MAST2chr1

46425058

+
intron-3CDSENST00000542471ENST00000361297WDR25chr14

100848083

+MAST2chr1

46425058

+
intron-intronENST00000542471ENST00000477968WDR25chr14

100848083

+MAST2chr1

46425058

+
Frame-shiftENST00000554175ENST00000372009WDR25chr14

100848083

+MAST2chr1

46425058

+
Frame-shiftENST00000554175ENST00000361297WDR25chr14

100848083

+MAST2chr1

46425058

+
5CDS-intronENST00000554175ENST00000477968WDR25chr14

100848083

+MAST2chr1

46425058

+
intron-3CDSENST00000557502ENST00000372009WDR25chr14

100848083

+MAST2chr1

46425058

+
intron-3CDSENST00000557502ENST00000361297WDR25chr14

100848083

+MAST2chr1

46425058

+
intron-intronENST00000557502ENST00000477968WDR25chr14

100848083

+MAST2chr1

46425058

+

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FusionProtFeatures for WDR25_MAST2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR25

Q64LD2

MAST2

Q6P0Q8

Appears to link the dystrophin/utrophin network withmicrotubule filaments via the syntrophins. Phosphorylation of DMDor UTRN may modulate their affinities for associated proteins.Functions in a multi-protein complex in spermatid maturation.Regulates lipopolysaccharide-induced IL-12 synthesis inmacrophages by forming a complex with TRAF6, resulting in theinhibition of TRAF6 NF-kappa-B activation (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR25_MAST2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR25_MAST2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR25PSME3, TRIM23, KRT31, PNMA1, KRT40, NOTCH2NL, NOTCH3, IMPDH1, CCT7MAST2CDHR2, GCN1L1, TRAF6, TRAF2, SNTB2, SH3GL2, TK1, SMN1, STK36, RASSF1, LATS1, APP, HSP90AA1, YWHAE, SUMO2, YWHAB, FBXW11, BTRC, SRPK2, GAN, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR25_MAST2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR25_MAST2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource