	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 41819

FusionGeneSummary for WDR20_PPP2R5C

Fusion gene summary

Fusion gene information	Fusion gene name: WDR20_PPP2R5C
	Fusion gene ID: 41819
		Hgene	Tgene
	Gene symbol	WDR20	PPP2R5C
	Gene ID	91833	5527
	Gene name	WD repeat domain 20	protein phosphatase 2 regulatory subunit B'gamma
	Synonyms	DMR	B56G\|B56gamma\|PR61G
	Cytomap	14q32.31	14q32.31
	Type of gene	protein-coding	protein-coding
	Description	WD repeat-containing protein 20	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat
	Modification date	20180519	20180523
	UniProtAcc	Q8TBZ3	Q13362
	Ensembl transtripts involved in fusion gene	ENST00000335263, ENST00000424963, ENST00000322340, ENST00000499851, ENST00000342702, ENST00000556807, ENST00000558567, ENST00000299135, ENST00000454394, ENST00000556511, ENST00000557186, ENST00000545563,	ENST00000422945, ENST00000556068, ENST00000554442, ENST00000328724, ENST00000350249, ENST00000445439, ENST00000334743, ENST00000557095, ENST00000556260, ENST00000556946, ENST00000557714,
Fusion gene scores	* DoF score	7 X 3 X 6=126	10 X 9 X 8=720
	# samples	7	13
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WDR20 [Title/Abstract] AND PPP2R5C [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PPP2R5C	GO:0008285	negative regulation of cell proliferation	17245430

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UCEC	TCGA-FI-A3PV-01A	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
TCGA	LD	UCEC	TCGA-FI-A3PV-01A	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000335263	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000335263	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000424963	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000322340	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000499851	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000342702	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556807	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000558567	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000299135	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5CDS-intron	ENST00000454394	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
intron-intron	ENST00000556511	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
3UTR-intron	ENST00000557186	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
5UTR-intron	ENST00000545563	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102302506	+
Frame-shift	ENST00000335263	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000335263	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-3CDS	ENST00000424963	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000424963	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
Frame-shift	ENST00000322340	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000322340	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-3CDS	ENST00000499851	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000499851	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
Frame-shift	ENST00000342702	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000342702	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-3CDS	ENST00000556807	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556807	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
Frame-shift	ENST00000558567	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000558567	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-3CDS	ENST00000299135	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000299135	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
Frame-shift	ENST00000454394	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5CDS-intron	ENST00000454394	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-3CDS	ENST00000556511	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
intron-intron	ENST00000556511	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-3CDS	ENST00000557186	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
3UTR-intron	ENST00000557186	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-3CDS	ENST00000545563	ENST00000422945	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000556068	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000554442	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000328724	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000350249	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000445439	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000334743	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000557095	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000556260	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000556946	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+
5UTR-intron	ENST00000545563	ENST00000557714	WDR20	chr14	102661457	+	PPP2R5C	chr14	102323023	+

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FusionProtFeatures for WDR20_PPP2R5C

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
WDR20 Q8TBZ3	PPP2R5C Q13362
	The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. The PP2A-PPP2R5C holoenzyme may specificallydephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may alsoregulate the ERK signaling pathway through ERK dephosphorylation.{ECO:0000269\|PubMed:16456541, ECO:0000269\|PubMed:17245430}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for WDR20_PPP2R5C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR20_PPP2R5C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
WDR20	COL11A2, PDHA1, PKN2, SURF2, YWHAB, YWHAH, POLR1C, OPTN, UBXN1, FBXW5, WDR48, USP12, USP46, PHLPP2, PHLPP1, UBL4A, USP12P1, LIG4, YWHAQ, ZDHHC17, TYK2, VSX1, MRM1, VSX2, DAPP1, TMEM17, XPO1, HSP90AA1, AR, FERMT2, TSPYL6, RNF19B, TRIM35, C15orf27, HSPB8, USH1C	PPP2R5C	CCNG2, PPP2CA, PPP2R5A, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, MBP, TBC1D3, APP, BRCA1, PAXIP1, IER3, MAPK1, SOX2, COL4A3BP, FAF1, JMJD6, PACSIN2, UGP2, PSMG3, SWAP70, EGFR, EP300, FAM43A, CCNG1, API5, LSM6, LSM7, PPP2R2A, POLD1, PPP2R5E, RQCD1, TP53, PRR14, PPP1CA, PPP1CB, PPP1CC, TRIM25

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for WDR20_PPP2R5C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for WDR20_PPP2R5C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PPP2R5C	C0023434	Chronic Lymphocytic Leukemia	1	CTD_human
Tgene	PPP2R5C	C1257806	Chromosomal Instability	1	CTD_human
Tgene	PPP2R5C	C1449861	Micronuclei, Chromosome-Defective	1	CTD_human

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Fusion gene ID: 41819

FusionGeneSummary for WDR20_PPP2R5C

FusionProtFeatures for WDR20_PPP2R5C

FusionGeneSequence for WDR20_PPP2R5C

FusionGenePPI for WDR20_PPP2R5C

RelatedDrugs for WDR20_PPP2R5C

RelatedDiseases for WDR20_PPP2R5C