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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41810

FusionGeneSummary for WDR1_GCDH

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR1_GCDH
Fusion gene ID: 41810
HgeneTgene
Gene symbol

WDR1

GCDH

Gene ID

9948

2639

Gene nameWD repeat domain 1glutaryl-CoA dehydrogenase
SynonymsAIP1|HEL-S-52|NORI-1ACAD5|GCD
Cytomap

4p16.1

19p13.13

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 1actin-interacting protein 1epididymis secretory protein Li 52glutaryl-CoA dehydrogenase, mitochondrialglutaryl-Coenzyme A dehydrogenasetruncated GCDHtruncated glutaryl-CoA dehydrogenase
Modification date2018052320180523
UniProtAcc

O75083

Q92947

Ensembl transtripts involved in fusion geneENST00000499869, ENST00000382451, 
ENST00000382452, ENST00000515743, 
ENST00000502702, 
ENST00000222214, 
ENST00000591470, ENST00000457854, 
ENST00000422947, ENST00000588242, 
Fusion gene scores* DoF score4 X 7 X 2=566 X 7 X 4=168
# samples 77
** MAII scorelog2(7/56*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR1 [Title/Abstract] AND GCDH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWDR1

GO:0030834

regulation of actin filament depolymerization

15629458

HgeneWDR1

GO:0043297

apical junction assembly

25792565

HgeneWDR1

GO:0045199

maintenance of epithelial cell apical/basal polarity

25792565

TgeneGCDH

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

25416781


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA167420WDR1chr4

10080617

+GCDHchr19

13004932

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000499869ENST00000222214WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000499869ENST00000591470WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000499869ENST00000457854WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000499869ENST00000422947WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000499869ENST00000588242WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382451ENST00000222214WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382451ENST00000591470WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382451ENST00000457854WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382451ENST00000422947WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382451ENST00000588242WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382452ENST00000222214WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382452ENST00000591470WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382452ENST00000457854WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382452ENST00000422947WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000382452ENST00000588242WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000515743ENST00000222214WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000515743ENST00000591470WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000515743ENST00000457854WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000515743ENST00000422947WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000515743ENST00000588242WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000502702ENST00000222214WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000502702ENST00000591470WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000502702ENST00000457854WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000502702ENST00000422947WDR1chr4

10080617

+GCDHchr19

13004932

+
intron-intronENST00000502702ENST00000588242WDR1chr4

10080617

+GCDHchr19

13004932

+

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FusionProtFeatures for WDR1_GCDH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR1

O75083

GCDH

Q92947

Induces disassembly of actin filaments in conjunctionwith ADF/cofilin family proteins (PubMed:15629458). Enhancescofilin-mediated actin severing (By similarity). Involved incytokinesis. Involved in chemotactic cell migration by restrictinglamellipodial membrane protrusions (PubMed:18494608). Involved inmyocardium sarcomere organization. Required for cardiomyocytegrowth and maintenance (By similarity). Involved in megakaryocytematuration and platelet shedding. Required for the establishmentof planar cell polarity (PCP) during follicular epitheliumdevelopment and for cell shape changes during PCP; the functionseems to implicate cooperation with CFL1 and/or DSTN/ADF. Involvedin the generation/maintenance of cortical tension (By similarity).Involved in assembly and maintenance of epithelial apical celljunctions and plays a role in the organization of theperijunctional actomyosin belt (PubMed:25792565).{ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2,ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608,ECO:0000269|PubMed:25792565}. Catalyzes the oxidative decarboxylation of glutaryl-CoAto crotonyl-CoA and CO(2) in the degradative pathway of L-lysine,L-hydroxylysine, and L-tryptophan metabolism. It uses electrontransfer flavoprotein as its electron acceptor. Isoform Short isinactive. {ECO:0000269|PubMed:17176108,ECO:0000269|PubMed:6423663, ECO:0000269|PubMed:8541831}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR1_GCDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR1_GCDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR1_GCDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR1_GCDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWDR1C0021368Inflammation1CTD_human
HgeneWDR1C0029456Osteoporosis1CTD_human
HgeneWDR1C0040034Thrombocytopenia1CTD_human
TgeneGCDHC0268595Glutaric aciduria, type 17CTD_human;ORPHANET;UNIPROT