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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41805

FusionGeneSummary for WDR13_PBX3

check button Fusion gene summary
Fusion gene informationFusion gene name: WDR13_PBX3
Fusion gene ID: 41805
HgeneTgene
Gene symbol

WDR13

PBX3

Gene ID

64743

5090

Gene nameWD repeat domain 13PBX homeobox 3
SynonymsMG21-
Cytomap

Xp11.23

9q33.3

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing protein 13pre-B-cell leukemia transcription factor 3homeobox protein PBX3pre-B-cell leukemia homeobox 3
Modification date2018051920180519
UniProtAcc

Q9H1Z4

P40426

Ensembl transtripts involved in fusion geneENST00000376729, ENST00000218056, 
ENST00000492715, 
ENST00000342287, 
ENST00000373487, ENST00000373489, 
ENST00000373483, ENST00000447726, 
ENST00000538998, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 4 X 5=140
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDR13 [Title/Abstract] AND PBX3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-HB-A3YV-01AWDR13chrX

48462778

+PBX3chr9

128691934

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000376729ENST00000342287WDR13chrX

48462778

+PBX3chr9

128691934

+
Frame-shiftENST00000376729ENST00000373487WDR13chrX

48462778

+PBX3chr9

128691934

+
Frame-shiftENST00000376729ENST00000373489WDR13chrX

48462778

+PBX3chr9

128691934

+
5CDS-5UTRENST00000376729ENST00000373483WDR13chrX

48462778

+PBX3chr9

128691934

+
5CDS-5UTRENST00000376729ENST00000447726WDR13chrX

48462778

+PBX3chr9

128691934

+
5CDS-3UTRENST00000376729ENST00000538998WDR13chrX

48462778

+PBX3chr9

128691934

+
Frame-shiftENST00000218056ENST00000342287WDR13chrX

48462778

+PBX3chr9

128691934

+
Frame-shiftENST00000218056ENST00000373487WDR13chrX

48462778

+PBX3chr9

128691934

+
Frame-shiftENST00000218056ENST00000373489WDR13chrX

48462778

+PBX3chr9

128691934

+
5CDS-5UTRENST00000218056ENST00000373483WDR13chrX

48462778

+PBX3chr9

128691934

+
5CDS-5UTRENST00000218056ENST00000447726WDR13chrX

48462778

+PBX3chr9

128691934

+
5CDS-3UTRENST00000218056ENST00000538998WDR13chrX

48462778

+PBX3chr9

128691934

+
intron-3CDSENST00000492715ENST00000342287WDR13chrX

48462778

+PBX3chr9

128691934

+
intron-3CDSENST00000492715ENST00000373487WDR13chrX

48462778

+PBX3chr9

128691934

+
intron-3CDSENST00000492715ENST00000373489WDR13chrX

48462778

+PBX3chr9

128691934

+
intron-5UTRENST00000492715ENST00000373483WDR13chrX

48462778

+PBX3chr9

128691934

+
intron-5UTRENST00000492715ENST00000447726WDR13chrX

48462778

+PBX3chr9

128691934

+
intron-3UTRENST00000492715ENST00000538998WDR13chrX

48462778

+PBX3chr9

128691934

+

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FusionProtFeatures for WDR13_PBX3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDR13

Q9H1Z4

PBX3

P40426

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDR13_PBX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDR13_PBX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDR13B3GAT3, EPHA1, TRIM25PBX3AGTRAP, HOXA9, HOXB8, ZNHIT3, RABAC1, MAGEA1, TPM3, TRAF1, ARL6IP1, MAGEC2, TRIM44, MAL2, FSD2, LMX1B, MAB21L1, MEIS2, MAB21L2, PTEN, FOXE1, FAM222A, C5orf24, C16orf71, VWA5A, CCDC120, TMOD3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDR13_PBX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDR13_PBX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource