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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41801

FusionGeneSummary for WDPCP_VPS54

check button Fusion gene summary
Fusion gene informationFusion gene name: WDPCP_VPS54
Fusion gene ID: 41801
HgeneTgene
Gene symbol

WDPCP

VPS54

Gene ID

51057

51542

Gene nameWD repeat containing planar cell polarity effectorVPS54, GARP complex subunit
SynonymsBBS15|C2orf86|CHDTHP|CPLANE5|FRITZ|FRTZHCC8|PPP1R164|SLP-8p|VPS54L|WR|hVps54L
Cytomap

2p15

2p15-p14

Type of geneprotein-codingprotein-coding
DescriptionWD repeat-containing and planar cell polarity effector protein fritz homologBardet-Biedl syndrome 15 proteinWD repeat-containing protein C2orf86ciliogenesis and planar polarity effector 5vacuolar protein sorting-associated protein 54hepatocellular carcinoma protein 8protein phosphatase 1, regulatory subunit 164tumor antigen HOM-HCC-8tumor antigen SLP-8pvacuolar protein sorting 54 homolog
Modification date2018052320180523
UniProtAcc

O95876

Q9P1Q0

Ensembl transtripts involved in fusion geneENST00000272321, ENST00000409199, 
ENST00000409120, ENST00000398544, 
ENST00000409562, ENST00000409835, 
ENST00000409558, ENST00000272322, 
ENST00000354504, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 5 X 4=100
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDPCP [Title/Abstract] AND VPS54 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A256-01AWDPCPchr2

63719990

-VPS54chr2

64176297

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000272321ENST00000409558WDPCPchr2

63719990

-VPS54chr2

64176297

-
Frame-shiftENST00000272321ENST00000272322WDPCPchr2

63719990

-VPS54chr2

64176297

-
Frame-shiftENST00000272321ENST00000354504WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000409199ENST00000409558WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000409199ENST00000272322WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000409199ENST00000354504WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000409120ENST00000409558WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000409120ENST00000272322WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000409120ENST00000354504WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000398544ENST00000409558WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000398544ENST00000272322WDPCPchr2

63719990

-VPS54chr2

64176297

-
intron-3CDSENST00000398544ENST00000354504WDPCPchr2

63719990

-VPS54chr2

64176297

-
Frame-shiftENST00000409562ENST00000409558WDPCPchr2

63719990

-VPS54chr2

64176297

-
Frame-shiftENST00000409562ENST00000272322WDPCPchr2

63719990

-VPS54chr2

64176297

-
Frame-shiftENST00000409562ENST00000354504WDPCPchr2

63719990

-VPS54chr2

64176297

-
5UTR-3CDSENST00000409835ENST00000409558WDPCPchr2

63719990

-VPS54chr2

64176297

-
5UTR-3CDSENST00000409835ENST00000272322WDPCPchr2

63719990

-VPS54chr2

64176297

-
5UTR-3CDSENST00000409835ENST00000354504WDPCPchr2

63719990

-VPS54chr2

64176297

-

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FusionProtFeatures for WDPCP_VPS54


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDPCP

O95876

VPS54

Q9P1Q0

Probable effector of the planar cell polarity signalingpathway which regulates the septin cytoskeleton in bothciliogenesis and collective cell movements. Together with FUZ andWDPCP proposed to function as core component of the CPLANE(ciliogenesis and planar polarity effectors) complex involved inthe recruitment of peripheral IFT-A proteins to basal bodies (Bysimilarity). {ECO:0000250|UniProtKB:Q32NR9,ECO:0000250|UniProtKB:Q8C456}. Acts as component of the GARP complex that is involvedin retrograde transport from early and late endosomes to thetrans-Golgi network (TGN). The GARP complex is required for themaintenance of the cycling of mannose 6-phosphate receptorsbetween the TGN and endosomes, this cycling is necessary forproper lysosomal sorting of acid hydrolases such as CTSD(PubMed:18367545). Within the GARP complex, required to tether thecomplex to the TGN. Not involved in endocytic recycling(PubMed:25799061). {ECO:0000269|PubMed:18367545,ECO:0000269|PubMed:25799061}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDPCP_VPS54


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDPCP_VPS54


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDPCPTRIM25VPS54VPS52, VPS53, VPS51, STX6, CCDC132, TSSC1, SYN1, C10orf76, PTAR1, RAB1A, RAB1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDPCP_VPS54


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WDPCP_VPS54


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWDPCPC1857587Orstavik Lindemann Solberg syndrome1UNIPROT
TgeneVPS54C0027746Nerve Degeneration1CTD_human