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Fusion gene ID: 418 |
FusionGeneSummary for ACOT1_OAS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACOT1_OAS3 | Fusion gene ID: 418 | Hgene | Tgene | Gene symbol | ACOT1 | OAS3 | Gene ID | 641371 | 4940 |
| Gene name | acyl-CoA thioesterase 1 | 2'-5'-oligoadenylate synthetase 3 | |
| Synonyms | ACH2|CTE-1|LACH2 | p100|p100OAS | |
| Cytomap | 14q24.3 | 12q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acyl-coenzyme A thioesterase 1CTE-ICTE-Ibinducible cytosolic acyl-coenzyme A thioester hydrolaselong chain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolase | 2'-5'-oligoadenylate synthase 3(2-5')oligo(A) synthase 3(2-5')oligo(A) synthetase 32'-5'-oligoadenylate synthetase 3, 100kDa2'-5'oligoadenylate synthetase p1002-5A synthase 32-5A synthetase 3p100 OAS | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86TX2 | Q9Y6K5 | |
| Ensembl transtripts involved in fusion gene | ENST00000311148, ENST00000557556, | ENST00000228928, ENST00000551007, ENST00000548514, ENST00000546638, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ACOT1 [Title/Abstract] AND OAS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACOT1 | GO:0000038 | very long-chain fatty acid metabolic process | 16940157 |
| Hgene | ACOT1 | GO:0001676 | long-chain fatty acid metabolic process | 16940157 |
| Hgene | ACOT1 | GO:0006637 | acyl-CoA metabolic process | 16940157 |
| Tgene | OAS3 | GO:0009615 | response to virus | 19056102 |
| Tgene | OAS3 | GO:0045071 | negative regulation of viral genome replication | 19056102|19923450 |
| Tgene | OAS3 | GO:0051607 | defense response to virus | 19923450 |
| Tgene | OAS3 | GO:0060700 | regulation of ribonuclease activity | 19923450 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM915691 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000311148 | ENST00000228928 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| intron-intron | ENST00000311148 | ENST00000551007 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| intron-intron | ENST00000311148 | ENST00000548514 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| intron-intron | ENST00000311148 | ENST00000546638 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| intron-3UTR | ENST00000557556 | ENST00000228928 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| intron-intron | ENST00000557556 | ENST00000551007 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| intron-intron | ENST00000557556 | ENST00000548514 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
| intron-intron | ENST00000557556 | ENST00000546638 | ACOT1 | chr14 | 74036258 | + | OAS3 | chr12 | 113410085 | + |
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FusionProtFeatures for ACOT1_OAS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACOT1 | OAS3 |
| Acyl-CoA thioesterases are a group of enzymes thatcatalyze the hydrolysis of acyl-CoAs to the free fatty acid andcoenzyme A (CoASH), providing the potential to regulateintracellular levels of acyl-CoAs, free fatty acids and CoASH.Active towards fatty acyl-CoA with chain-lengths of C12-C16 (Bysimilarity). {ECO:0000250}. | Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response.In addition, it may also play a role in other cellular processessuch as apoptosis, cell growth, differentiation and generegulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactivemonomeric form of ribonuclease L (RNase L) leading to itsdimerization and subsequent activation. Activation of RNase Lleads to degradation of cellular as well as viral RNA, resultingin the inhibition of protein synthesis, thus terminating viralreplication. Can mediate the antiviral effect via the classicalRNase L-dependent pathway or an alternative antiviral pathwayindependent of RNase L. Displays antiviral activity againstChikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) andSemliki forest virus (SFV). {ECO:0000269|PubMed:19056102,ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACOT1_OAS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACOT1_OAS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACOT1_OAS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACOT1_OAS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACOT1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Hgene | ACOT1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | OAS3 | C0021400 | Influenza | 1 | CTD_human |
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