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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41787

FusionGeneSummary for WDFY3_HNRNPD

check button Fusion gene summary
Fusion gene informationFusion gene name: WDFY3_HNRNPD
Fusion gene ID: 41787
HgeneTgene
Gene symbol

WDFY3

HNRNPD

Gene ID

23001

3184

Gene nameWD repeat and FYVE domain containing 3heterogeneous nuclear ribonucleoprotein D
SynonymsALFY|BCHS|MCPH18|ZFYVE25AUF1|AUF1A|HNRPD|P37|hnRNPD0
Cytomap

4q21.23

4q21.22

Type of geneprotein-codingprotein-coding
DescriptionWD repeat and FYVE domain-containing protein 3autophagy-linked FYVE proteinheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
Modification date2018051920180523
UniProtAcc

Q8IZQ1

Q14103

Ensembl transtripts involved in fusion geneENST00000322366, ENST00000295888, 
ENST00000512267, 
ENST00000313899, 
ENST00000353341, ENST00000543098, 
ENST00000352301, ENST00000508119, 
ENST00000541060, 
Fusion gene scores* DoF score7 X 6 X 5=21010 X 10 X 3=300
# samples 712
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/300*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WDFY3 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-J4-A67M-01AWDFY3chr4

85818064

-HNRNPDchr4

83276554

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000322366ENST00000313899WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-3CDSENST00000322366ENST00000353341WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-3CDSENST00000322366ENST00000543098WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-3CDSENST00000322366ENST00000352301WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-5UTRENST00000322366ENST00000508119WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-5UTRENST00000322366ENST00000541060WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-3CDSENST00000295888ENST00000313899WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-3CDSENST00000295888ENST00000353341WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-3CDSENST00000295888ENST00000543098WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-3CDSENST00000295888ENST00000352301WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-5UTRENST00000295888ENST00000508119WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
5UTR-5UTRENST00000295888ENST00000541060WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
intron-3CDSENST00000512267ENST00000313899WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
intron-3CDSENST00000512267ENST00000353341WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
intron-3CDSENST00000512267ENST00000543098WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
intron-3CDSENST00000512267ENST00000352301WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
intron-5UTRENST00000512267ENST00000508119WDFY3chr4

85818064

-HNRNPDchr4

83276554

-
intron-5UTRENST00000512267ENST00000541060WDFY3chr4

85818064

-HNRNPDchr4

83276554

-

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FusionProtFeatures for WDFY3_HNRNPD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WDFY3

Q8IZQ1

HNRNPD

Q14103


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WDFY3_HNRNPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WDFY3_HNRNPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WDFY3SQSTM1, MAP1LC3A, ATG5, ATG12, ATG16L1, BAG3, TRAF6, PRMT1, PRMT6, SUV39H1, EEF2K, ZBTB44, TRIM39, CEP76, SHMT2, MOV10, NXF1, HLA-B, HLA-E, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3C, GRB2, RABGAP1L, STAT3, PIK3R3, TENC1, MDFI, DAXX, NFE2L1, RAB5C, S100A4, WEE1, RTEL1, TERF2IP, SGTB, TMEM132A, NEDD1, BAG6, FLCN, DEF8, HERC1, DCAF6, APAF1, ICAM1, CD79B, RHOT2, PDCD1, DMWD, DDX11, P2RX2, WDR60, WDR75, ALG13, SLC2A12, VCAM1, DPYSL4HNRNPDLSM5, SAFB, TRN-GTT2-1, HSPB1, HSPA4, HSPA8, EIF4G1, HNRNPD, HNRNPH1, CDK9, MEPCE, KHDRBS2, GPN1, BANF1, MTA2, HDAC1, PABPC1, H2AFX, CD4, HDAC5, HSPB2, MAPK6, PCBP1, PCBP2, VHL, SMARCAD1, SREK1, ARRB2, HNRNPA1, PAIP1, BCL2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SYNCRIP, YBX1, IGF2BP2, UBE2I, MEOX2, GRB2, VEGFA, TNF, HNRNPR, PTBP1, RBMX, HNRNPF, HNRNPL, HNRNPA2B1, HNRNPA0, HNRNPA3, MRPL12, RPS28, RALY, HNRNPDL, AHNAK, RMDN3, SEPT9, SLC30A5, DDX1, MSH2, SMURF1, SFN, FN1, VCAM1, SNRPC, SF3B4, U2AF2, HNRNPC, HNRNPU, HNRNPK, HNRNPH3, PTBP2, IFIT2, IFIT3, IL7R, BRCA1, ITGA4, PAN2, CD81, IGSF8, ICAM1, HMGA1, C1QBP, RPSA, ACTB, GTF3C3, CD97, EXOSC4, EEF2, SNAPC4, ABCC10, BET1L, TSEN34, CINP, SHISA5, MPP1, TMEM261, GUK1, P4HB, FLNA, ARF4, SLC3A2, MAP2K1, HIRA, DGCR2, CAPN1, HBZ, PDLIM7, IMMT, PYCR1, SLC27A5, NTMT1, DHX30, CUTA, GTSE1, FBXL15, COL18A1, IMMP2L, COG7, PPOX, CTSB, PEX10, UQCRC1, PRDX3, SDF2, B3GAT3, PARK2, EIF3K, DENR, IPO11, ERI1, PAFAH1B3, KHSRP, RPS12, WNK1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, IVNS1ABP, STAU1, NCL, KAT2B, FUS, ING4, MYC, ENO1, MOV10, NXF1, MDM2, CUL7, OBSL1, EED, ESR1, BTRC, FBXW11, PTGS2, CHEK1, DNAJC7, HNRNPAB, AURKA, C2orf49, HSPA9, NAA50, PICALM, PKM, SFPQ, TARS, TOMM34, UBE2G2, PGK1, NTRK1, SCARNA22, EWSR1, BLMH, SLC25A20, CETN2, DKC1, DNM2, ETFA, FANCD2, ACSL4, MTOR, GOLGA4, HEXA, DYNC1H1, HNRNPH2, MYEF2, HSD17B4, HSPA6, ITGB4, EIF6, MAP3K4, MYH1, NHS, PDCL, PLXNB1, PPM1A, RBM4, RET, SRSF6, UAP1, TARBP1, GCFC2, TLN1, TNFRSF1A, BAG6, USP11, DYSF, NRP1, TAX1BP1, FUBP3, GTF2IRD1, ESPL1, ARHGAP32, C2CD5, OSBPL2, RBM8A, PRMT3, SAP18, ABCA7, TUBB3, PPIH, SRSF10, COG2, FNDC3A, MORC2, FAM120A, USP24, KIAA0368, DICER1, SIRT5, KLHDC2, INTS7, PKN3, PNPLA8, CHMP5, UHRF1BP1, RASIP1, PINX1, HEATR3, SMEK2, ZNF286A, GPBP1, PDRG1, SBF2, TLN2, KLF16, OBSCN, WDR24, GPRIN1, MRPL55, PTGR2, PPP1R18, DDX51, HNRNPCL1, MCM2, SNW1, CYLD, TRIM25, UBE2A, HEY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WDFY3_HNRNPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational

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RelatedDiseases for WDFY3_HNRNPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource