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Fusion gene ID: 41761 |
FusionGeneSummary for WBP1L_ADAMTS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WBP1L_ADAMTS2 | Fusion gene ID: 41761 | Hgene | Tgene | Gene symbol | WBP1L | ADAMTS2 | Gene ID | 54838 | 9509 |
| Gene name | WW domain binding protein 1 like | ADAM metallopeptidase with thrombospondin type 1 motif 2 | |
| Synonyms | C10orf26|OPA1L|OPAL1 | ADAM-TS2|ADAMTS-2|ADAMTS-3|EDSDERMS|NPI|PC I-NP|PCI-NP|PCINP|PCPNI|PNPI | |
| Cytomap | 10q24.32 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | WW domain binding protein 1-likeoutcome predictor in acute leukemia 1 | A disintegrin and metalloproteinase with thrombospondin motifs 2a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2procollagen I N-proteinaseprocollagen I/II amino propeptide-processing enzymeprocollagen N-endo | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NX94 | O95450 | |
| Ensembl transtripts involved in fusion gene | ENST00000448841, ENST00000369889, | ENST00000251582, ENST00000274609, | |
| Fusion gene scores | * DoF score | 11 X 9 X 10=990 | 5 X 5 X 3=75 |
| # samples | 17 | 5 | |
| ** MAII score | log2(17/990*10)=-2.54189377882927 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: WBP1L [Title/Abstract] AND ADAMTS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A1KT-01A | WBP1L | chr10 | 104503900 | + | ADAMTS2 | chr5 | 178700065 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000448841 | ENST00000251582 | WBP1L | chr10 | 104503900 | + | ADAMTS2 | chr5 | 178700065 | - |
| In-frame | ENST00000448841 | ENST00000274609 | WBP1L | chr10 | 104503900 | + | ADAMTS2 | chr5 | 178700065 | - |
| intron-3CDS | ENST00000369889 | ENST00000251582 | WBP1L | chr10 | 104503900 | + | ADAMTS2 | chr5 | 178700065 | - |
| intron-3CDS | ENST00000369889 | ENST00000274609 | WBP1L | chr10 | 104503900 | + | ADAMTS2 | chr5 | 178700065 | - |
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FusionProtFeatures for WBP1L_ADAMTS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WBP1L | ADAMTS2 |
| Cleaves the propeptides of type I and II collagen priorto fibril assembly. Does not act on type III collagen. May alsoplay a role in development that is independent of its role incollagen biosynthesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 185_188 | 178 | 1212 | Compositional bias | Note=Poly-Glu |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 618_722 | 178 | 1212 | Compositional bias | Note=Cys-rich |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 185_188 | 178 | 567 | Compositional bias | Note=Poly-Glu |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 618_722 | 178 | 567 | Compositional bias | Note=Cys-rich |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 1059_1097 | 178 | 1212 | Domain | PLAC |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 266_470 | 178 | 1212 | Domain | Peptidase M12B |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 480_560 | 178 | 1212 | Domain | Note=Disintegrin |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 561_616 | 178 | 1212 | Domain | TSP type-1 1 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 854_912 | 178 | 1212 | Domain | TSP type-1 2 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 914_971 | 178 | 1212 | Domain | TSP type-1 3 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 975_1029 | 178 | 1212 | Domain | TSP type-1 4 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 1059_1097 | 178 | 567 | Domain | PLAC |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 266_470 | 178 | 567 | Domain | Peptidase M12B |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 480_560 | 178 | 567 | Domain | Note=Disintegrin |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 561_616 | 178 | 567 | Domain | TSP type-1 1 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 854_912 | 178 | 567 | Domain | TSP type-1 2 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 914_971 | 178 | 567 | Domain | TSP type-1 3 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 975_1029 | 178 | 567 | Domain | TSP type-1 4 |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 691_693 | 178 | 1212 | Motif | Cell attachment site |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 691_693 | 178 | 567 | Motif | Cell attachment site |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 723_851 | 178 | 1212 | Region | Note=Spacer |
| Tgene | >ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 723_851 | 178 | 567 | Region | Note=Spacer |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >WBP1L | chr10:104503900 | chr5:178700065 | ENST00000369889 | + | 1 | 4 | 101_183 | -48 | 343 | Compositional bias | Note=Pro-rich |
| Hgene | >WBP1L | chr10:104503900 | chr5:178700065 | ENST00000369889 | + | 1 | 4 | 335_342 | -48 | 343 | Compositional bias | Note=Poly-Ser |
| Hgene | >WBP1L | chr10:104503900 | chr5:178700065 | ENST00000448841 | + | 1 | 4 | 101_183 | 30 | 364 | Compositional bias | Note=Pro-rich |
| Hgene | >WBP1L | chr10:104503900 | chr5:178700065 | ENST00000448841 | + | 1 | 4 | 335_342 | 30 | 364 | Compositional bias | Note=Poly-Ser |
| Hgene | >WBP1L | chr10:104503900 | chr5:178700065 | ENST00000369889 | + | 1 | 4 | 42_62 | -48 | 343 | Transmembrane | Helical |
| Hgene | >WBP1L | chr10:104503900 | chr5:178700065 | ENST00000448841 | + | 1 | 4 | 42_62 | 30 | 364 | Transmembrane | Helical |
| Tgene | ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000251582 | - | 1 | 22 | 40_43 | 178 | 1212 | Compositional bias | Note=Poly-Ala |
| Tgene | ADAMTS2 | chr10:104503900 | chr5:178700065 | ENST00000274609 | - | 1 | 11 | 40_43 | 178 | 567 | Compositional bias | Note=Poly-Ala |
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FusionGeneSequence for WBP1L_ADAMTS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_WBP1L_ENST00000448841_chr10_104503900_+_ADAMTS2_ENST00000251582_chr5_178700065_-_1064aa MERRRLLGGMALLLLQALPSPLSARAEPPQAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDS LSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH DGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRT FDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGR TCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSL CVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEE NDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSK PCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKH CNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRP DPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPST >In-frame_WBP1L_ENST00000448841_chr10_104503900_+_ADAMTS2_ENST00000274609_chr5_178700065_-_419aa MERRRLLGGMALLLLQALPSPLSARAEPPQAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDS LSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH DGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_WBP1L_ENST00000448841_chr10_104503900_+_ADAMTS2_ENST00000251582_chr5_178700065_-_3192nt ATGGAGAGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAG GCTGGTCTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTG CATGTGGTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGGGGCCTCCCTGGACAGCCTGGACAGC CTCAGCCGCGCCCTGGGCGTCCTAGAGGAGCACGCCAACAGCTCGAGGCGGAGGGCACGCAGGCATGCTGCGGACGATGACTACAACATC GAGGTCCTGCTGGGCGTGGATGACTCTGTGGTGCAGTTCCACGGGAAGGAGCACGTACAGAAGTACCTGCTGACACTCATGAACATTGTC AATGAAATCTACCATGACGAGTCCTTGGGTGCCCACATCAACGTGGTCCTGGTGCGGATCATCCTCCTGAGCTATGGAAAGTCCATGAGC CTCATCGAGATCGGGAACCCCTCTCAGAGCCTGGAGAATGTCTGCCGCTGGGCCTACCTCCAGCAGAAGCCAGACACGGGCCACGATGAA TACCACGATCACGCCATCTTCCTCACACGGCAGGACTTTGGGCCTTCCGGCATGCAAGGCTATGCTCCTGTCACCGGCATGTGCCATCCG GTCCGCAGCTGCACCCTGAACCATGAGGACGGCTTCTCCTCAGCGTTTGTGGTGGCCCATGAGACTGGCCACGTGCTGGGCATGGAGCAC GACGGGCAGGGCAACCGCTGTGGCGACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCCGCCTTCCACCGCTTCCACTGG TCCCGCTGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTGCTGGATGACCCCTTCGCCCACGACTGGCCGGCGCTG CCCCAGCTCCCGGGACTGCACTACTCCATGAACGAGCAATGCCGCTTTGACTTCGGCCTGGGCTACATGATGTGCACGGCGTTCCGGACC TTTGACCCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACAACCCCTACTTTTGCAAGACCAAGAAGGGGCCCCCCTTGGACGGGACTATG TGTGCACCTGGCAAGCATTGTTTTAAAGGACACTGCATCTGGCTGACACCTGACATCCTCAAACGGGACGGCAGCTGGGGCGCTTGGAGT CCGTTTGGCTCCTGCTCACGTACCTGTGGCACGGGCGTGAAGTTCAGGACCCGCCAGTGTGACAACCCACACCCGGCCAACGGGGGCCGC ACCTGCTCGGGCCTTGCCTACGACTTCCAGCTCTGCAGCCGCCAGGACTGCCCCGACTCCCTGGCTGACTTCCGCGAGGAGCAGTGCCGC CAGTGGGACCTGTACTTCGAGCACGGCGACGCCCAGCACCACTGGCTGCCCCACGAGCACCGGGATGCCAAGGAGAGATGCCACCTGTAC TGCGAGTCCAGGGAGACCGGGGAGGTGGTGTCCATGAAGCGCATGGTGCATGACGGGACGCGCTGCTCCTACAAGGACGCCTTCAGCCTC TGTGTGCGCGGGGACTGCAGGAAGGTGGGCTGTGACGGTGTGATCGGCTCCAGCAAGCAGGAAGACAAGTGTGGCGTGTGCGGAGGGGAC AACAGCCACTGCAAAGTGGTCAAGGGCACGTTCACACGGTCACCCAAGAAGCATGGTTACATCAAGATGTTTGAGATCCCTGCAGGAGCC AGACACCTGCTCATTCAGGAGGTAGACGCCACCAGCCACCATCTGGCCGTCAAGAACCTGGAGACAGGCAAGTTCATCTTAAATGAAGAG AATGACGTGGATGCCAGTTCCAAAACCTTCATTGCCATGGGCGTGGAGTGGGAGTACAGAGACGAGGACGGCCGGGAGACGCTGCAGACC ATGGGCCCCCTCCACGGCACCATCACCGTTCTGGTCATCCCGGTGGGAGACACCCGGGTCTCACTGACGTACAAATACATGATCCATGAG GACTCACTGAATGTCGACGACAACAACGTCCTGGAAGAGGACTCTGTGGTCTACGAGTGGGCCCTGAAGAAGTGGTCTCCGTGCTCCAAG CCCTGTGGCGGAGGGTCCCAGTTCACCAAGTATGGCTGCCGCCGGAGGCTGGACCACAAGATGGTACACCGTGGCTTCTGTGCCGCCCTC TCGAAGCCCAAAGCCATCCGCAGAGCGTGCAACCCACAGGAATGCTCCCAGCCAGTGTGGGTCACAGGCGAATGGGAGCCATGTAGCCAG ACCTGTGGGCGGACAGGCATGCAGGTGCGCTCCGTGCGCTGCATTCAGCCGCTACACGACAACACCACCCGCTCCGTGCACGCCAAGCAC TGCAATGACGCCCGGCCCGAGAGCCGCCGGGCCTGCAGCCGCGAGCTCTGCCCTGGTCGTTGGCGAGCCGGGCCCTGGTCCCAGTGCTCA GTAACCTGTGGCAACGGCACCCAGGAGCGGCCAGTGCTCTGCCGCACCGCGGACGACAGCTTCGGCATCTGCCAGGAGGAGCGTCCTGAG ACAGCGAGGACCTGCAGGCTTGGCCCCTGTCCCCGAAACATCTCAGATCCCTCCAAGAAGAGCTACGTAGTTCAGTGGCTGTCCCGCCCG GACCCCGACTCGCCCATCCGGAAGATCTCGTCAAAGGGCCACTGCCAAGGCGACAAGTCAATATTCTGTAGGATGGAAGTCTTGTCCCGC TATTGCTCCATCCCAGGCTACAACAAGCTGTGCTGCAAGTCCTGTAACCTGTACAACAACCTCACCAACGTGGAGGGCAGGATAGAGCCA CCGCCTGGGAAGCACAACGACATTGACGTGTTCATGCCTACCCTCCCAGTGCCCACTGTAGCCATGGAGGTGCGGCCATCACCAAGCACC CCCCTGGAGGTCCCTCTCAATGCCTCCAGCACCAATGCCACAGAGGATCACCCAGAAACCAATGCCGTAGATGAACCCTACAAAATCCAT GGCCTGGAAGATGAAGTCCAGCCACCCAACCTAATCCCTCGACGACCGAGCCCCTATGAAAAGACCAGAAACCAAAGAATCCAAGAGCTC >In-frame_WBP1L_ENST00000448841_chr10_104503900_+_ADAMTS2_ENST00000274609_chr5_178700065_-_1257nt ATGGAGAGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAG GCTGGTCTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTG CATGTGGTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGGGGCCTCCCTGGACAGCCTGGACAGC CTCAGCCGCGCCCTGGGCGTCCTAGAGGAGCACGCCAACAGCTCGAGGCGGAGGGCACGCAGGCATGCTGCGGACGATGACTACAACATC GAGGTCCTGCTGGGCGTGGATGACTCTGTGGTGCAGTTCCACGGGAAGGAGCACGTACAGAAGTACCTGCTGACACTCATGAACATTGTC AATGAAATCTACCATGACGAGTCCTTGGGTGCCCACATCAACGTGGTCCTGGTGCGGATCATCCTCCTGAGCTATGGAAAGTCCATGAGC CTCATCGAGATCGGGAACCCCTCTCAGAGCCTGGAGAATGTCTGCCGCTGGGCCTACCTCCAGCAGAAGCCAGACACGGGCCACGATGAA TACCACGATCACGCCATCTTCCTCACACGGCAGGACTTTGGGCCTTCCGGCATGCAAGGCTATGCTCCTGTCACCGGCATGTGCCATCCG GTCCGCAGCTGCACCCTGAACCATGAGGACGGCTTCTCCTCAGCGTTTGTGGTGGCCCATGAGACTGGCCACGTGCTGGGCATGGAGCAC GACGGGCAGGGCAACCGCTGTGGCGACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCCGCCTTCCACCGCTTCCACTGG TCCCGCTGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTGCTGGATGACCCCTTCGCCCACGACTGGCCGGCGCTG CCCCAGCTCCCGGGACTGCACTACTCCATGAACGAGCAATGCCGCTTTGACTTCGGCCTGGGCTACATGATGTGCACGGCGTTCCGGACC TTTGACCCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACAACCCCTACTTTTGCAAGACCAAGAAGGGGCCCCCCTTGGACGGGACTATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_WBP1L_ENST00000448841_chr10_104503900_+_ADAMTS2_ENST00000251582_chr5_178700065_-_6292nt GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGGCTGGT CTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTGCATGTG GTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGGGGCCTCCCTGGACAGCCTGGACAGCCTCAGC CGCGCCCTGGGCGTCCTAGAGGAGCACGCCAACAGCTCGAGGCGGAGGGCACGCAGGCATGCTGCGGACGATGACTACAACATCGAGGTC CTGCTGGGCGTGGATGACTCTGTGGTGCAGTTCCACGGGAAGGAGCACGTACAGAAGTACCTGCTGACACTCATGAACATTGTCAATGAA ATCTACCATGACGAGTCCTTGGGTGCCCACATCAACGTGGTCCTGGTGCGGATCATCCTCCTGAGCTATGGAAAGTCCATGAGCCTCATC GAGATCGGGAACCCCTCTCAGAGCCTGGAGAATGTCTGCCGCTGGGCCTACCTCCAGCAGAAGCCAGACACGGGCCACGATGAATACCAC GATCACGCCATCTTCCTCACACGGCAGGACTTTGGGCCTTCCGGCATGCAAGGCTATGCTCCTGTCACCGGCATGTGCCATCCGGTCCGC AGCTGCACCCTGAACCATGAGGACGGCTTCTCCTCAGCGTTTGTGGTGGCCCATGAGACTGGCCACGTGCTGGGCATGGAGCACGACGGG CAGGGCAACCGCTGTGGCGACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCCGCCTTCCACCGCTTCCACTGGTCCCGC TGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTGCTGGATGACCCCTTCGCCCACGACTGGCCGGCGCTGCCCCAG CTCCCGGGACTGCACTACTCCATGAACGAGCAATGCCGCTTTGACTTCGGCCTGGGCTACATGATGTGCACGGCGTTCCGGACCTTTGAC CCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACAACCCCTACTTTTGCAAGACCAAGAAGGGGCCCCCCTTGGACGGGACTATGTGTGCA CCTGGCAAGCATTGTTTTAAAGGACACTGCATCTGGCTGACACCTGACATCCTCAAACGGGACGGCAGCTGGGGCGCTTGGAGTCCGTTT GGCTCCTGCTCACGTACCTGTGGCACGGGCGTGAAGTTCAGGACCCGCCAGTGTGACAACCCACACCCGGCCAACGGGGGCCGCACCTGC TCGGGCCTTGCCTACGACTTCCAGCTCTGCAGCCGCCAGGACTGCCCCGACTCCCTGGCTGACTTCCGCGAGGAGCAGTGCCGCCAGTGG GACCTGTACTTCGAGCACGGCGACGCCCAGCACCACTGGCTGCCCCACGAGCACCGGGATGCCAAGGAGAGATGCCACCTGTACTGCGAG TCCAGGGAGACCGGGGAGGTGGTGTCCATGAAGCGCATGGTGCATGACGGGACGCGCTGCTCCTACAAGGACGCCTTCAGCCTCTGTGTG CGCGGGGACTGCAGGAAGGTGGGCTGTGACGGTGTGATCGGCTCCAGCAAGCAGGAAGACAAGTGTGGCGTGTGCGGAGGGGACAACAGC CACTGCAAAGTGGTCAAGGGCACGTTCACACGGTCACCCAAGAAGCATGGTTACATCAAGATGTTTGAGATCCCTGCAGGAGCCAGACAC CTGCTCATTCAGGAGGTAGACGCCACCAGCCACCATCTGGCCGTCAAGAACCTGGAGACAGGCAAGTTCATCTTAAATGAAGAGAATGAC GTGGATGCCAGTTCCAAAACCTTCATTGCCATGGGCGTGGAGTGGGAGTACAGAGACGAGGACGGCCGGGAGACGCTGCAGACCATGGGC CCCCTCCACGGCACCATCACCGTTCTGGTCATCCCGGTGGGAGACACCCGGGTCTCACTGACGTACAAATACATGATCCATGAGGACTCA CTGAATGTCGACGACAACAACGTCCTGGAAGAGGACTCTGTGGTCTACGAGTGGGCCCTGAAGAAGTGGTCTCCGTGCTCCAAGCCCTGT GGCGGAGGGTCCCAGTTCACCAAGTATGGCTGCCGCCGGAGGCTGGACCACAAGATGGTACACCGTGGCTTCTGTGCCGCCCTCTCGAAG CCCAAAGCCATCCGCAGAGCGTGCAACCCACAGGAATGCTCCCAGCCAGTGTGGGTCACAGGCGAATGGGAGCCATGTAGCCAGACCTGT GGGCGGACAGGCATGCAGGTGCGCTCCGTGCGCTGCATTCAGCCGCTACACGACAACACCACCCGCTCCGTGCACGCCAAGCACTGCAAT GACGCCCGGCCCGAGAGCCGCCGGGCCTGCAGCCGCGAGCTCTGCCCTGGTCGTTGGCGAGCCGGGCCCTGGTCCCAGTGCTCAGTAACC TGTGGCAACGGCACCCAGGAGCGGCCAGTGCTCTGCCGCACCGCGGACGACAGCTTCGGCATCTGCCAGGAGGAGCGTCCTGAGACAGCG AGGACCTGCAGGCTTGGCCCCTGTCCCCGAAACATCTCAGATCCCTCCAAGAAGAGCTACGTAGTTCAGTGGCTGTCCCGCCCGGACCCC GACTCGCCCATCCGGAAGATCTCGTCAAAGGGCCACTGCCAAGGCGACAAGTCAATATTCTGTAGGATGGAAGTCTTGTCCCGCTATTGC TCCATCCCAGGCTACAACAAGCTGTGCTGCAAGTCCTGTAACCTGTACAACAACCTCACCAACGTGGAGGGCAGGATAGAGCCACCGCCT GGGAAGCACAACGACATTGACGTGTTCATGCCTACCCTCCCAGTGCCCACTGTAGCCATGGAGGTGCGGCCATCACCAAGCACCCCCCTG GAGGTCCCTCTCAATGCCTCCAGCACCAATGCCACAGAGGATCACCCAGAAACCAATGCCGTAGATGAACCCTACAAAATCCATGGCCTG GAAGATGAAGTCCAGCCACCCAACCTAATCCCTCGACGACCGAGCCCCTATGAAAAGACCAGAAACCAAAGAATCCAAGAGCTCATTGAT GAGATGCGGAAGAAAGAGATGCTCGGAAAGTTCTAATAAAATGGAAAGATAGCATCCCTAGCATTTTTTTCTTGCTTATAGAGATATTCC ATGGGATAGCAAATCCTGTGTCATGGAGATGAAGTCAAAATTCCTGATTCCAAAAGGTTTTGAGAAAACAAAGAGGGGGAATGACGTAAG AAAGATAGGCATGAGCATGTGGTAACTAGGTTAGCACGTGTGCTTCCCAGCCCAGGAGCGACCAAATACTGTGGTGGCGTCAGGTGTGCA GTGGAGAGGAATATAGAGGCTGTATGGCCTCCCTCAGTGAGGGCAGGGCAAGAGGGATCACTCTGAGAGAACAAAAATAGGCCCCAAGTT GCTAAGCAGTGATTGGGAACCTTCCTTTCCTTGGCGGAGATGCATGACATTCCCTACCGATCCCCAGACACAGCCTGTGGGACTCTTAGG AGAAATGGTGATTTACTGAATAACTGACCCGTTGCCGAGATGAGTACAATGAAGTGGAGGTGATGAACTCAAATCGTCTTCCAGGGCCAG GCGGCTGACCGGGGTGAGCGTAGTGGCCCGCTGGGGACCATGGCCGCCCTGACAGCCACACCCACCTGGAGCTGACTTGGTTCTGGCTGT TGCTGCCACTGTGAAATCTGTATCTCTCTCCATCTCTGCTCTACTATCCCCGGCCTTGCCAGACAGTGTTCTTTTTCGGAAGAAGTCTAG ATTTTTGCATGAAAAAAACTCAATCTTTAAAGGTCGACTCAGAACATTTTAAGGAGGCCTCCACTTGGTCTGATGCAGTCTTGCTAATTA AGAACTAAAGGCCTTCTGACCTTCTTGGTGCTCATGCTGTACGGCATCTGAATGTCTCGACCGAGTCTGAGCCGTGCAGCTGTCCTCCAC CTGCGAAAGTAATGAGAATCCTATCACGGGACATAAGGATAGGTCTAAACAGGGTCCATGCCAAGAAAACAGTGGGGTGCTCTCCCAGGC CTCTCCCCTGTCCACTAACCCTGGCCTTGCCGGCTGCCTTCCAGGCTCTGGGGGAAGAGCTCCTGCATTCTTCCCTGGCCACCTTGGCTC CAGGGCTCCCCAGAGAGCCTCTTCCCTCCCCAAGTACCTGAGAAAGATGAGAGAGGCACGTGCTCTGCTGGGAAGGTCCAGTGAGCGGTT CAAGGGCCTGGAATCTCCCTACGGCCAAGTCTAAGGGTTCTGGGATTCTGGGCTTTGTGGGCTTTGCTTGCTTGCTGGGAATGGGCTTTC CCTGTCCCGCCCTGCCCCACCTCGCCTCTGTCTCTCAGAAGCTCCAGAACCCAGCAGTGACCTGCAAAATGTGGCCTCTGATGGGGGCTT AGGGTGGGAGATGGGGAGAGCCTACATTGTCTTTTGCTCCTTGAAAACTTTAATAGCTCCTATTTTCCAGAGAATGGTGCTTTGTGAGCA ACATGCGAGTAAGAGAGAAATAGGAGGAAGGGGGAGTAGGGGCGGATGGGAGAAGAGTGGCTCATTTTTACCTCTCACTGCCTTGACATT TTGTGAACGTGAAGCTTAAACTTTCTGGGCTTACAAGACCCAGGGGCACGTCAGCTCCTTAGATGGGCTCAGCCTGACACATAATTCTTA AACCTTTCCTGTTTAAGAAACTTCTAGAGGCTGTGTACTCTCACCAATCCTCTTCGAGAATTTGTTCATGTGTATTTCCCCATTATATGG ATGAGGCTCAGGATAACAGCATAGTGGCTACCTTCTACTGAGTTTTGAGGTGCTAATAAGTATGTTTGTCTGAGGCTGCACATGTGGGTG GCTCTGTGTGTATGATCCAAGGGACAAAATGACGATGTAGGAACCAGCAAGAACGGAATCTGGGCTGATGCTTCAGTCTCCACCTGGGTG ATGGCTAGCCTCCCGCCCTCCACCACCGCATCCCACACGTGCTGCGCACTGTCCCCGTGTCTCCTGGAGAACCAAACTGGAGAAAACCTT TCTGAGTATCTCTCATAGTACCCCTTCCTTAAGAAGATGTGGTTTAGAGCATGTGTGCAATCCTGCCTCTGTAATTAGGAAACGGAGCCC GAGGCTTTCCATTGTTGGTTGAACCCAGGACAGCTGGTGCTATTCACAGGCTGAAGAACTGGGCAGTTCTTACTTGGGTCTGTCCTAGGA TGTGGAGGAAGTTCAGGACTAACGCTAGGCAGAGAGTATGACTCGGTTTACCCAGCCTAGGGGCCTCTGGATGGGAACACTCCATTCCAA GATCTCAGCAGAGCAGGGCTTCCTGGCTTGAGGCTGGAAGCCTTTGGGAAGAGGCCCAGCTGGGACATTCCCTGGGCACCTGTCTTCCGC TGAAGGGAGCAAGGTGCCCTCTGGGACTGACAGCCATGACCCTCTGTGCCATCCTCAATCCTTGAGCCATATATCAAGAGTCCTCTAGAG CCGGATGGTCCTCAAAAGTCTGTCCAAGGAATGCCAACGTTCACCGGGCTCTGAGAAACGACGCAAATCTCTGAGCTGGGGACCACTTGG AGAACCGGCTTAGTAACAGTCCTGATCTTCGCAAGCCAGCTTCTTCTGCATCTGAGGGGCTCCTGGCGCCCAGAGGAGGCAGACAGATGT CTTCTAGCTGAGTTTCTAACCGCATGATGAGACTCAGACCTTCCGCTGCACTAGAAAATCTGCAACAGTGTCCCTGAGTCACTTCTCCTT AGTGGGCAGACTCGTGTTAGATTTGTGGAACCCAGCTCTCTGATTTACTCCTTTTGGAAAACCCATGGAATTTCATGTATAAGGCTTTCA TTTGTATTTTAAGGTTTTTCTGTTTGTTTTGAGTATATACATGGTGCTCAATAGCAACATCTTAGCAGATGAAGCAGTTTATGATTCCAC TCCCTCCTGTATGACAGGTAGCCACTATACTGAATCAAGGTGCTGAACTCAAATCACAAAATTCTGGCTTACCGATACAACAACCAATAC >In-frame_WBP1L_ENST00000448841_chr10_104503900_+_ADAMTS2_ENST00000274609_chr5_178700065_-_1582nt GAAGGAAGAAGAGGGTAGAGGAGGAGAGGGAGGAGGAGGAGGGAGGTGGCGGCGCCGTGGCGGAGGAGCAGGAGCAGGAGGGGGATGGAG AGGAGAAGGCTCCTGGGTGGCATGGCGCTCCTGCTCCTCCAGGCGCTGCCCAGCCCCTTGTCAGCCAGGGCTGAACCCCCGCAGGCTGGT CTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTGCATGTG GTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGGGGCCTCCCTGGACAGCCTGGACAGCCTCAGC CGCGCCCTGGGCGTCCTAGAGGAGCACGCCAACAGCTCGAGGCGGAGGGCACGCAGGCATGCTGCGGACGATGACTACAACATCGAGGTC CTGCTGGGCGTGGATGACTCTGTGGTGCAGTTCCACGGGAAGGAGCACGTACAGAAGTACCTGCTGACACTCATGAACATTGTCAATGAA ATCTACCATGACGAGTCCTTGGGTGCCCACATCAACGTGGTCCTGGTGCGGATCATCCTCCTGAGCTATGGAAAGTCCATGAGCCTCATC GAGATCGGGAACCCCTCTCAGAGCCTGGAGAATGTCTGCCGCTGGGCCTACCTCCAGCAGAAGCCAGACACGGGCCACGATGAATACCAC GATCACGCCATCTTCCTCACACGGCAGGACTTTGGGCCTTCCGGCATGCAAGGCTATGCTCCTGTCACCGGCATGTGCCATCCGGTCCGC AGCTGCACCCTGAACCATGAGGACGGCTTCTCCTCAGCGTTTGTGGTGGCCCATGAGACTGGCCACGTGCTGGGCATGGAGCACGACGGG CAGGGCAACCGCTGTGGCGACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCCGCCTTCCACCGCTTCCACTGGTCCCGC TGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTGCTGGATGACCCCTTCGCCCACGACTGGCCGGCGCTGCCCCAG CTCCCGGGACTGCACTACTCCATGAACGAGCAATGCCGCTTTGACTTCGGCCTGGGCTACATGATGTGCACGGCGTTCCGGACCTTTGAC CCCTGCAAGCAGCTGTGGTGCAGCCATCCTGACAACCCCTACTTTTGCAAGACCAAGAAGGGGCCCCCCTTGGACGGGACTATGTGTGCA CCTGGCAAGTTCAGGCCGGGCGCGGTGGCTCATGCCTGTTATCCCAGCACTTTGGGAGGCCAAGGTAGGTGGATCGCCTGAGGTCAGAAG TTCAAGACAAGTCTGGTTAACATGGCAAAATCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGCGGTGGTGGGTGCCTGTAATCCC AGCTACTCCGGAGGCTGAGGCATGAAAATCGTTTGAGCCCAGGAGGCGGAGGTTGCGGTGAGCCAAGATCGCGTCGCTGCTCTCCAGTCT |
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FusionGenePPI for WBP1L_ADAMTS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| WBP1L | LIG4, SGTA | ADAMTS2 | PIK3R1, TAZ, CD1B, CLEC12A, SUSD4, IDS, B3GNT2, LIPH, PRG2, TMPRSS11B, DKKL1, ST8SIA4, SLAMF1, TCTN2, LYPD4, ADAM2, ADAMTS4, ADAM30 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WBP1L_ADAMTS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WBP1L_ADAMTS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ADAMTS2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
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