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Fusion gene ID: 41756 |
FusionGeneSummary for WASL_RALBP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: WASL_RALBP1 | Fusion gene ID: 41756 | Hgene | Tgene | Gene symbol | WASL | RALBP1 | Gene ID | 8976 | 85021 |
| Gene name | Wiskott-Aldrich syndrome like | RALBP1 associated Eps domain containing 1 | |
| Synonyms | N-WASP|NWASP|WASPB | NBIA7|RALBP1 | |
| Cytomap | 7q31.32 | 6q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neural Wiskott-Aldrich syndrome protein | ralBP1-associated Eps domain-containing protein 1ralBP1-interacting protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O00401 | Q15311 | |
| Ensembl transtripts involved in fusion gene | ENST00000223023, | ENST00000019317, ENST00000383432, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: WASL [Title/Abstract] AND RALBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | WASL | GO:1903526 | negative regulation of membrane tubulation | 18388313 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD522431 | WASL | chr7 | 123323709 | - | RALBP1 | chr18 | 9516972 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000223023 | ENST00000019317 | WASL | chr7 | 123323709 | - | RALBP1 | chr18 | 9516972 | + |
| intron-3CDS | ENST00000223023 | ENST00000383432 | WASL | chr7 | 123323709 | - | RALBP1 | chr18 | 9516972 | + |
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FusionProtFeatures for WASL_RALBP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WASL | RALBP1 |
| Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis andcytokinesis, via its role in the regulation of actinpolymerization. Binds to HSF1/HSTF1 and forms a complex on heatshock promoter elements (HSE) that negatively regulates HSP90expression. Plays a role in dendrite spine morphogenesis (Bysimilarity). {ECO:0000250|UniProtKB:Q91YD9,ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689,ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828}. | Can activate specifically hydrolysis of GTP bound toRAC1 and CDC42, but not RALA. Mediates ATP-dependent transport ofS-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX)and is the major ATP-dependent transporter of glutathioneconjugates of electrophiles (GS-E) and DOX in erythrocytes. Cancatalyze transport of glutathione conjugates and xenobiotics, andmay contribute to the multidrug resistance phenomenon. Serves as ascaffold protein that brings together proteins forming anendocytotic complex during interphase and also with CDK1 to switchoff endocytosis, One of its substrates would be EPN1/Epsin.{ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:12775724,ECO:0000269|PubMed:7673236}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WASL_RALBP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WASL_RALBP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WASL_RALBP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WASL_RALBP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | WASL | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | RALBP1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | RALBP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | RALBP1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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