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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41751

FusionGeneSummary for WASF3_XRN2

check button Fusion gene summary
Fusion gene informationFusion gene name: WASF3_XRN2
Fusion gene ID: 41751
HgeneTgene
Gene symbol

WASF3

XRN2

Gene ID

10810

22803

Gene nameWAS protein family member 35'-3' exoribonuclease 2
SynonymsBrush-1|SCAR3|WAVE3-
Cytomap

13q12.13

20p11.22

Type of geneprotein-codingprotein-coding
Descriptionwiskott-Aldrich syndrome protein family member 3WASP family Verprolin-homologous protein 3protein WAVE-3verprolin homology domain-containing protein 35'-3' exoribonuclease 2DHP proteinDhm1-like protein
Modification date2018051920180519
UniProtAcc

Q9UPY6

Q9H0D6

Ensembl transtripts involved in fusion geneENST00000361042, ENST00000335327, 
ENST00000496788, 
ENST00000377191, 
ENST00000430571, ENST00000539513, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 1=16
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WASF3 [Title/Abstract] AND XRN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneXRN2

GO:0000738

DNA catabolic process, exonucleolytic

15565158


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ683058WASF3chr13

27261841

+XRN2chr20

21346298

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000361042ENST00000377191WASF3chr13

27261841

+XRN2chr20

21346298

+
3UTR-3CDSENST00000361042ENST00000430571WASF3chr13

27261841

+XRN2chr20

21346298

+
3UTR-3CDSENST00000361042ENST00000539513WASF3chr13

27261841

+XRN2chr20

21346298

+
3UTR-3CDSENST00000335327ENST00000377191WASF3chr13

27261841

+XRN2chr20

21346298

+
3UTR-3CDSENST00000335327ENST00000430571WASF3chr13

27261841

+XRN2chr20

21346298

+
3UTR-3CDSENST00000335327ENST00000539513WASF3chr13

27261841

+XRN2chr20

21346298

+
intron-3CDSENST00000496788ENST00000377191WASF3chr13

27261841

+XRN2chr20

21346298

+
intron-3CDSENST00000496788ENST00000430571WASF3chr13

27261841

+XRN2chr20

21346298

+
intron-3CDSENST00000496788ENST00000539513WASF3chr13

27261841

+XRN2chr20

21346298

+

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FusionProtFeatures for WASF3_XRN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WASF3

Q9UPY6

XRN2

Q9H0D6

Downstream effector molecules involved in thetransmission of signals from tyrosine kinase receptors and smallGTPases to the actin cytoskeleton. Plays a role in the regulationof cell morphology and cytoskeletal organization. Required in thecontrol of cell shape. {ECO:0000269|PubMed:17623672,ECO:0000269|PubMed:21834987}. Possesses 5'->3' exoribonuclease activity (Bysimilarity). May promote the termination of transcription by RNApolymerase II. During transcription termination, cleavage at thepolyadenylation site liberates a 5' fragment which is subsequentlyprocessed to form the mature mRNA and a 3' fragment which remainsattached to the elongating polymerase. The processive degradationof this 3' fragment by this protein may promote termination oftranscription. Binds to RNA polymerase II (RNAp II) transcriptiontermination R-loops formed by G-rich pause sites(PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158,ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WASF3_XRN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WASF3_XRN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WASF3_XRN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WASF3_XRN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWASF3C3495559Juvenile arthritis1CTD_human