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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41732

FusionGeneSummary for WARS_CCNY

check button Fusion gene summary
Fusion gene informationFusion gene name: WARS_CCNY
Fusion gene ID: 41732
HgeneTgene
Gene symbol

WARS

CCNY

Gene ID

7453

219771

Gene nametryptophanyl-tRNA synthetasecyclin Y
SynonymsGAMMA-2|HMN9|IFI53|IFP53C10orf9|CBCP1|CCNX|CFP1
Cytomap

14q32.2

10p11.21

Type of geneprotein-codingprotein-coding
Descriptiontryptophan--tRNA ligase, cytoplasmichWRSinterferon-induced protein 53trpRStryptophan tRNA ligase 1, cytoplasmiccyclin-Ycyc-Ycyclin box protein 1cyclin fold protein 1cyclin-Xcyclin-box carrying protein 1
Modification date2018052320180523
UniProtAcc

P23381

Q8ND76

Ensembl transtripts involved in fusion geneENST00000392882, ENST00000358655, 
ENST00000355338, ENST00000344102, 
ENST00000557135, ENST00000556645, 
ENST00000554084, 		ENST00000374706, 
ENST00000265375, ENST00000339497, 
ENST00000374704, ENST00000492478, 
Fusion gene scores* DoF score8 X 9 X 5=3604 X 4 X 3=48
# samples 106
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: WARS [Title/Abstract] AND CCNY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWARS

GO:0001933

negative regulation of protein phosphorylation

22504299

HgeneWARS

GO:0006469

negative regulation of protein kinase activity

22504299

HgeneWARS

GO:0010628

positive regulation of gene expression

22504299

HgeneWARS

GO:0010835

regulation of protein ADP-ribosylation

22504299

HgeneWARS

GO:0045765

regulation of angiogenesis

11773625|11773626

TgeneCCNY

GO:0000086

G2/M transition of mitotic cell cycle

20059949

TgeneCCNY

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

19524571|20059949

TgeneCCNY

GO:0060828

regulation of canonical Wnt signaling pathway

20059949


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-EM-A3AQ-01AWARSchr14

100828045

-CCNYchr10

35772332

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000392882ENST00000374706WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000392882ENST00000265375WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000392882ENST00000339497WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000392882ENST00000374704WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-3UTRENST00000392882ENST00000492478WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000358655ENST00000374706WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000358655ENST00000265375WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000358655ENST00000339497WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000358655ENST00000374704WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-3UTRENST00000358655ENST00000492478WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000355338ENST00000374706WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000355338ENST00000265375WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000355338ENST00000339497WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000355338ENST00000374704WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-3UTRENST00000355338ENST00000492478WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000344102ENST00000374706WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000344102ENST00000265375WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000344102ENST00000339497WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000344102ENST00000374704WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-3UTRENST00000344102ENST00000492478WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000557135ENST00000374706WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000557135ENST00000265375WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000557135ENST00000339497WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000557135ENST00000374704WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-3UTRENST00000557135ENST00000492478WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000556645ENST00000374706WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-5UTRENST00000556645ENST00000265375WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000556645ENST00000339497WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-intronENST00000556645ENST00000374704WARSchr14

100828045

-CCNYchr10

35772332

+
5CDS-3UTRENST00000556645ENST00000492478WARSchr14

100828045

-CCNYchr10

35772332

+
5UTR-5UTRENST00000554084ENST00000374706WARSchr14

100828045

-CCNYchr10

35772332

+
5UTR-5UTRENST00000554084ENST00000265375WARSchr14

100828045

-CCNYchr10

35772332

+
5UTR-intronENST00000554084ENST00000339497WARSchr14

100828045

-CCNYchr10

35772332

+
5UTR-intronENST00000554084ENST00000374704WARSchr14

100828045

-CCNYchr10

35772332

+
5UTR-3UTRENST00000554084ENST00000492478WARSchr14

100828045

-CCNYchr10

35772332

+

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FusionProtFeatures for WARS_CCNY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WARS

P23381

CCNY

Q8ND76

Isoform 1, isoform 2 and T1-TrpRS have aminoacylationactivity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRSpossess angiostatic activity whereas isoform 1 lacks it. T2-TrpRSinhibits fluid shear stress-activated responses of endothelialcells. Regulates ERK, Akt, and eNOS activation pathways that areassociated with angiogenesis, cytoskeletal reorganization andshear stress-responsive gene expression.{ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626,ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:14630953,ECO:0000269|PubMed:28369220}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WARS_CCNY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WARS_CCNY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WARSMDH2, DDA1, GBAS, PSMA3, DCAF13, DNMT3B, SIRT7, ISG15, TERF1, APP, TRIM25, GART, LIG4, CD81, CALU, CDC34, CTPS2, GNPDA1, GTF2I, HERC4, PCNA, AARS, ADSL, EHD1, FKBP9, GTF3C4, KTN1, NT5C2, NUCB1, TWF1, RAD23A, USP5, XPNPEP1, FBXW11, CCT3, CTSD, HSD17B12, KPNA2, MVB12A, PFAS, PSMG1, RABIF, TATDN1, ACSS2, C14orf166, CCDC22, CDA, CEP41, EHD4, HARS, HIP1R, PSMG2, SARS, SH3GLB1, SMCHD1, TMOD1, TSG101, VPS37B, NTRK1, U2AF2, DUSP13, UBC, CYLDCCNYELAVL1, CDK14, CUL1, ABCE1, HOXB5, FYTTD1, TMEM185A, CCNL2, CYP51A1, CCNYL1, GJB7, KIFAP3, GPR141, SDC1, CDK16


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WARS_CCNY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneWARSP23381DB00150L-TryptophanTryptophan--tRNA ligase, cytoplasmicsmall moleculeapproved|nutraceutical|withdrawn

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RelatedDiseases for WARS_CCNY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCCNYC0009324Ulcerative Colitis1CTD_human
TgeneCCNYC0010346Crohn Disease1CTD_human