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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41719

FusionGeneSummary for WARS2_DLG2

check button Fusion gene summary
Fusion gene informationFusion gene name: WARS2_DLG2
Fusion gene ID: 41719
HgeneTgene
Gene symbol

WARS2

DLG2

Gene ID

10352

4355

Gene nametryptophanyl tRNA synthetase 2, mitochondrialmembrane palmitoylated protein 2
SynonymsNEMMLAS|TrpRSDLG2
Cytomap

1p12

17q21.31

Type of geneprotein-codingprotein-coding
Descriptiontryptophan--tRNA ligase, mitochondrial(Mt)TrpRStryptophan tRNA ligase 2, mitochondrialMAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Modification date2018052320180519
UniProtAcc

Q9UGM6

Q15700

Ensembl transtripts involved in fusion geneENST00000369426, ENST00000235521, 
ENST00000537870, ENST00000497761, 
ENST00000398309, ENST00000376104, 
ENST00000418306, ENST00000280241, 
ENST00000543673, ENST00000376106, 
ENST00000330014, ENST00000537455, 
ENST00000524982, ENST00000532653, 
ENST00000531015, ENST00000398301, 
ENST00000426717, ENST00000404783, 
ENST00000398304, ENST00000530800, 
ENST00000472545, 
Fusion gene scores* DoF score12 X 5 X 10=60016 X 15 X 6=1440
# samples 1220
** MAII scorelog2(12/600*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WARS2 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-A490-01AWARS2chr1

119683178

-DLG2chr11

84865695

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000369426ENST00000398309WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000376104WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000418306WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000280241WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000543673WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000376106WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000330014WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000537455WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000524982WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000532653WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000531015WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000398301WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000426717WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000404783WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000398304WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000530800WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000369426ENST00000472545WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000398309WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000376104WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000418306WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000280241WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000543673WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000376106WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000330014WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000537455WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000524982WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000532653WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000531015WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000398301WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000426717WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000404783WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000398304WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000530800WARS2chr1

119683178

-DLG2chr11

84865695

-
5CDS-intronENST00000235521ENST00000472545WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000398309WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000376104WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000418306WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000280241WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000543673WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000376106WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000330014WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000537455WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000524982WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000532653WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000531015WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000398301WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000426717WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000404783WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000398304WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000530800WARS2chr1

119683178

-DLG2chr11

84865695

-
intron-intronENST00000537870ENST00000472545WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000398309WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000376104WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000418306WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000280241WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000543673WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000376106WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000330014WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000537455WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000524982WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000532653WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000531015WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000398301WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000426717WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000404783WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000398304WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000530800WARS2chr1

119683178

-DLG2chr11

84865695

-
5UTR-intronENST00000497761ENST00000472545WARS2chr1

119683178

-DLG2chr11

84865695

-

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FusionProtFeatures for WARS2_DLG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WARS2

Q9UGM6

DLG2

Q15700

Mitochondrial aminoacyl-tRNA synthetase that activateand transfer the amino acids to their corresponding tRNAs duringthe translation of mitochondrial genes and protein synthesis.{ECO:0000305|PubMed:28650581}. Required for perception of chronic pain through NMDAreceptor signaling. Regulates surface expression of NMDA receptorsin dorsal horn neurons of the spinal cord. Interacts with thecytoplasmic tail of NMDA receptor subunits as well as inwardrectifying potassium channels. Involved in regulation of synapticstability at cholinergic synapses. Part of the postsynapticprotein scaffold of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WARS2_DLG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WARS2_DLG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WARS2APP, RMND5ADLG2LRP2, ERBB4, KCNJ12, KCNJ4, GRIN2B, KCNA4, DLGAP1, DYNLL1, DYNLL2, DLG4, NLGN2, NLGN1, NLGN3, GRIN2A, SEMA4C, NOS1, ATP2B2, ATP2B4, GUCY1A2, KHDRBS1, FASLG, MAP1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WARS2_DLG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneWARS2Q9UGM6DB00150L-TryptophanTryptophan--tRNA ligase, mitochondrialsmall moleculeapproved|nutraceutical|withdrawn

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RelatedDiseases for WARS2_DLG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDLG2C0036341Schizophrenia4PSYGENET
TgeneDLG2C0005586Bipolar Disorder2PSYGENET
TgeneDLG2C0025202melanoma1CTD_human
TgeneDLG2C0041696Unipolar Depression1PSYGENET
TgeneDLG2C0809983Schizophrenia and related disorders1PSYGENET
TgeneDLG2C1269683Major Depressive Disorder1PSYGENET