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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41715

FusionGeneSummary for WAC_VPS35

check button Fusion gene summary
Fusion gene informationFusion gene name: WAC_VPS35
Fusion gene ID: 41715
HgeneTgene
Gene symbol

WAC

VPS35

Gene ID

51322

55737

Gene nameWW domain containing adaptor with coiled-coilVPS35, retromer complex component
SynonymsBM-016|DESSH|PRO1741|Wwp4MEM3|PARK17
Cytomap

10p12.1|10p12.1-p11.2

16q11.2

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing adapter protein with coiled-coilvacuolar protein sorting-associated protein 35hVPS35maternal-embryonic 3vacuolar protein sorting 35 homolog
Modification date2018051920180523
UniProtAcc

Q9BTA9

Q96QK1

Ensembl transtripts involved in fusion geneENST00000375664, ENST00000375646, 
ENST00000347934, ENST00000354911, 
ENST00000428935, ENST00000532233, 
ENST00000299138, ENST00000568642, 
Fusion gene scores* DoF score8 X 9 X 3=2165 X 6 X 2=60
# samples 116
** MAII scorelog2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: WAC [Title/Abstract] AND VPS35 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVPS35

GO:0010628

positive regulation of gene expression

26618722

TgeneVPS35

GO:0032268

regulation of cellular protein metabolic process

26618722

TgeneVPS35

GO:0045056

transcytosis

15247922

TgeneVPS35

GO:0060161

positive regulation of dopamine receptor signaling pathway

27460146

TgeneVPS35

GO:0099639

neurotransmitter receptor transport, endosome to plasma membrane

27460146


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA435640WACchr10

28909410

-VPS35chr16

46694482

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000375664ENST00000299138WACchr10

28909410

-VPS35chr16

46694482

+
3UTR-intronENST00000375664ENST00000568642WACchr10

28909410

-VPS35chr16

46694482

+
intron-3CDSENST00000375646ENST00000299138WACchr10

28909410

-VPS35chr16

46694482

+
intron-intronENST00000375646ENST00000568642WACchr10

28909410

-VPS35chr16

46694482

+
3UTR-3CDSENST00000347934ENST00000299138WACchr10

28909410

-VPS35chr16

46694482

+
3UTR-intronENST00000347934ENST00000568642WACchr10

28909410

-VPS35chr16

46694482

+
3UTR-3CDSENST00000354911ENST00000299138WACchr10

28909410

-VPS35chr16

46694482

+
3UTR-intronENST00000354911ENST00000568642WACchr10

28909410

-VPS35chr16

46694482

+
intron-3CDSENST00000428935ENST00000299138WACchr10

28909410

-VPS35chr16

46694482

+
intron-intronENST00000428935ENST00000568642WACchr10

28909410

-VPS35chr16

46694482

+
intron-3CDSENST00000532233ENST00000299138WACchr10

28909410

-VPS35chr16

46694482

+
intron-intronENST00000532233ENST00000568642WACchr10

28909410

-VPS35chr16

46694482

+

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FusionProtFeatures for WAC_VPS35


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WAC

Q9BTA9

VPS35

Q96QK1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WAC_VPS35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WAC_VPS35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WAC_VPS35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WAC_VPS35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVPS35C0030567Parkinson Disease1CTD_human
TgeneVPS35C0036341Schizophrenia1CTD_human
TgeneVPS35C3280133PARKINSON DISEASE 171UNIPROT