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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41710

FusionGeneSummary for WAC_LRRC37A6P

check button Fusion gene summary
Fusion gene informationFusion gene name: WAC_LRRC37A6P
Fusion gene ID: 41710
HgeneTgene
Gene symbol

WAC

LRRC37A6P

Gene ID

51322

387646

Gene nameWW domain containing adaptor with coiled-coilleucine rich repeat containing 37 member A6, pseudogene
SynonymsBM-016|DESSH|PRO1741|Wwp4LRRC37E
Cytomap

10p12.1|10p12.1-p11.2

10p12.1

Type of geneprotein-codingpseudo
DescriptionWW domain-containing adapter protein with coiled-coilleucine rich repeat containing 37, member A family pseudogene
Modification date2018051920180329
UniProtAcc

Q9BTA9

Ensembl transtripts involved in fusion geneENST00000375664, ENST00000375646, 
ENST00000347934, ENST00000354911, 
ENST00000428935, ENST00000532233, 
ENST00000284414, 
Fusion gene scores* DoF score8 X 9 X 3=2162 X 2 X 2=8
# samples 112
** MAII scorelog2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: WAC [Title/Abstract] AND LRRC37A6P [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0U4-01AWACchr10

28824686

+LRRC37A6Pchr10

27535626

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375664ENST00000284414WACchr10

28824686

+LRRC37A6Pchr10

27535626

-
5CDS-intronENST00000375646ENST00000284414WACchr10

28824686

+LRRC37A6Pchr10

27535626

-
5CDS-intronENST00000347934ENST00000284414WACchr10

28824686

+LRRC37A6Pchr10

27535626

-
5CDS-intronENST00000354911ENST00000284414WACchr10

28824686

+LRRC37A6Pchr10

27535626

-
5CDS-intronENST00000428935ENST00000284414WACchr10

28824686

+LRRC37A6Pchr10

27535626

-
3UTR-intronENST00000532233ENST00000284414WACchr10

28824686

+LRRC37A6Pchr10

27535626

-

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FusionProtFeatures for WAC_LRRC37A6P


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
WAC

Q9BTA9

LRRC37A6P

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for WAC_LRRC37A6P


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for WAC_LRRC37A6P


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
WACKRT15, RNF20, RNF40, POLR2A, VCPIP1, VCP, TRAF3IP1, LNX1, UBQLN4, APP, QTRTD1, CRKL, NDE1, NFE2L2, TRAF1, AKAP9, MTUS2, WAC, TRAF3IP3, SYTL5, DYDC1, KLC3, ZDHHC17, SIRT6, UBE2A, UBE2B, UNK, TLN1, EWSR1, CBR1, SLAIN2, CDKN2AIPNL, CEP170P1, TPM2LRRC37A6P


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for WAC_LRRC37A6P


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WAC_LRRC37A6P


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource