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Fusion gene ID: 41684 |
FusionGeneSummary for VTI1A_GTF2H5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: VTI1A_GTF2H5 | Fusion gene ID: 41684 | Hgene | Tgene | Gene symbol | VTI1A | GTF2H5 | Gene ID | 143187 | 404672 |
Gene name | vesicle transport through interaction with t-SNAREs 1A | general transcription factor IIH subunit 5 | |
Synonyms | MMDS3|MVti1|VTI1RP2|Vti1-rp2 | C6orf175|TFB5|TFIIH|TGF2H5|TTD|TTD-A|TTD3|TTDA|bA120J8.2 | |
Cytomap | 10q25.2 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | vesicle transport through interaction with t-SNAREs homolog 1ASNARE Vti1a-beta proteinvesicle transport v-SNARE protein Vti1-like 2 | general transcription factor IIH subunit 5TFB5 orthologTFIIH basal transcription factor complex TTD-A subunitTFIIH basal transcription factor complex TTDA subunitgeneral transcription factor IIH, polypeptide 5 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q96AJ9 | Q6ZYL4 | |
Ensembl transtripts involved in fusion gene | ENST00000432306, ENST00000393077, ENST00000483122, | ENST00000607778, | |
Fusion gene scores | * DoF score | 6 X 3 X 9=162 | 5 X 2 X 4=40 |
# samples | 11 | 6 | |
** MAII score | log2(11/162*10)=-0.558490289359965 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/40*10)=0.584962500721156 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: VTI1A [Title/Abstract] AND GTF2H5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | VTI1A | GO:0042147 | retrograde transport, endosome to Golgi | 15215310|18195106 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-2262-01A | VTI1A | chr10 | 114298089 | + | GTF2H5 | chr6 | 158613009 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000432306 | ENST00000607778 | VTI1A | chr10 | 114298089 | + | GTF2H5 | chr6 | 158613009 | + |
In-frame | ENST00000393077 | ENST00000607778 | VTI1A | chr10 | 114298089 | + | GTF2H5 | chr6 | 158613009 | + |
intron-3CDS | ENST00000483122 | ENST00000607778 | VTI1A | chr10 | 114298089 | + | GTF2H5 | chr6 | 158613009 | + |
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FusionProtFeatures for VTI1A_GTF2H5 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
VTI1A | GTF2H5 |
V-SNARE that mediates vesicle transport pathways throughinteractions with t-SNAREs on the target membrane. Theseinteractions are proposed to mediate aspects of the specificity ofvesicle trafficking and to promote fusion of the lipid bilayers.Involved in vesicular transport from the late endosomes to thetrans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface usedby KCNIP1 and KCND2. May be involved in increased cytokinesecretion associated with cellular senescence.{ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. | Component of the general transcription and DNA repairfactor IIH (TFIIH) core complex, which is involved in general andtranscription-coupled nucleotide excision repair (NER) of damagedDNA and, when complexed to CAK, in RNA transcription by RNApolymerase II. In NER, TFIIH acts by opening DNA around the lesionto allow the excision of the damaged oligonucleotide and itsreplacement by a new DNA fragment. In transcription, TFIIH has anessential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is requiredfor promoter opening and promoter escape. Phosphorylation of theC-terminal tail (CTD) of the largest subunit of RNA polymerase IIby the kinase module CAK controls the initiation of transcription.Necessary for the stability of the TFIIH complex and for thepresence of normal levels of TFIIH in the cell.{ECO:0000269|PubMed:15220921}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | VTI1A | chr10:114298089 | chr6:158613009 | ENST00000393077 | + | 5 | 8 | 31_92 | 142 | 218 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | VTI1A | chr10:114298089 | chr6:158613009 | ENST00000432306 | + | 5 | 8 | 31_92 | 142 | 204 | Coiled coil | Ontology_term=ECO:0000255 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000393077 | + | 5 | 8 | 112_178 | 142 | 218 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000432306 | + | 5 | 8 | 112_178 | 142 | 204 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000393077 | + | 5 | 8 | 1_192 | 142 | 218 | Topological domain | Cytoplasmic |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000393077 | + | 5 | 8 | 214_217 | 142 | 218 | Topological domain | Extracellular |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000432306 | + | 5 | 8 | 1_192 | 142 | 204 | Topological domain | Cytoplasmic |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000432306 | + | 5 | 8 | 214_217 | 142 | 204 | Topological domain | Extracellular |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000393077 | + | 5 | 8 | 193_213 | 142 | 218 | Transmembrane | Helical |
Hgene | >VTI1A | chr10:114298089 | chr6:158613009 | ENST00000432306 | + | 5 | 8 | 193_213 | 142 | 204 | Transmembrane | Helical |
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FusionGeneSequence for VTI1A_GTF2H5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_VTI1A_ENST00000432306_chr10_114298089_+_GTF2H5_ENST00000607778_chr6_158613009_+_202aa MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKR SRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETVILPXSSFCCTWMSPMPWGRSSSFKTLMTLTSLXXQNW >In-frame_VTI1A_ENST00000393077_chr10_114298089_+_GTF2H5_ENST00000607778_chr6_158613009_+_202aa MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKR SRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETVILPXSSFCCTWMSPMPWGRSSSFKTLMTLTSLXXQNW |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_VTI1A_ENST00000432306_chr10_114298089_+_GTF2H5_ENST00000607778_chr6_158613009_+_608nt ATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCAAGATTGCGAGGGTCCCACGACTCCCG CCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGCTTGAACAGATGGATTTGGAAGTCCGA GAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGGGAAAACTCGAAACAGATTTTAAAAGG TCACGGATCGCCTACAGTGACGAAGTACGGAATGAGCTCCTGGGGGATGATGGGAATTCCTCAGAGAACCAGAGGGCACATCTGCTCGAT AACACAGAGAGGCTGGAAAGGTCATCTCGGAGACTAGAGGCTGGATACCAAATAGCAGTGGAAACCGTGATCCTGCCATGAAGCAGTTTC TGCTGTACTTGGATGAGTCCAATGCCCTGGGGAAGAAGTTCATCATTCAAGACATTGATGACACTCACGTCTTTGTAATAGCAGAATTGG >In-frame_VTI1A_ENST00000393077_chr10_114298089_+_GTF2H5_ENST00000607778_chr6_158613009_+_608nt ATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCAAGATTGCGAGGGTCCCACGACTCCCG CCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGCTTGAACAGATGGATTTGGAAGTCCGA GAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGGGAAAACTCGAAACAGATTTTAAAAGG TCACGGATCGCCTACAGTGACGAAGTACGGAATGAGCTCCTGGGGGATGATGGGAATTCCTCAGAGAACCAGAGGGCACATCTGCTCGAT AACACAGAGAGGCTGGAAAGGTCATCTCGGAGACTAGAGGCTGGATACCAAATAGCAGTGGAAACCGTGATCCTGCCATGAAGCAGTTTC TGCTGTACTTGGATGAGTCCAATGCCCTGGGGAAGAAGTTCATCATTCAAGACATTGATGACACTCACGTCTTTGTAATAGCAGAATTGG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_VTI1A_ENST00000432306_chr10_114298089_+_GTF2H5_ENST00000607778_chr6_158613009_+_7911nt CCGTTCTGCTCTCGGGGGCACCTTCCGGGGTTCCTAAGCCGCGGGGCCCCTCGCTGCCCCTCGAGGCCCTTTCCCTGACCTAGGCTTTGG CCTGGGCTACTCGTTCCGGAGCCGCCATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCA AGATTGCGAGGGTCCCACGACTCCCGCCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGC TTGAACAGATGGATTTGGAAGTCCGAGAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGG GAAAACTCGAAACAGATTTTAAAAGGTCACGGATCGCCTACAGTGACGAAGTACGGAATGAGCTCCTGGGGGATGATGGGAATTCCTCAG AGAACCAGAGGGCACATCTGCTCGATAACACAGAGAGGCTGGAAAGGTCATCTCGGAGACTAGAGGCTGGATACCAAATAGCAGTGGAAA CCGTGATCCTGCCATGAAGCAGTTTCTGCTGTACTTGGATGAGTCCAATGCCCTGGGGAAGAAGTTCATCATTCAAGACATTGATGACAC TCACGTCTTTGTAATAGCAGAATTGGTTAATGTCCTCCAGGAGCGAGTGGGTGAATTAATGGACCAAAATGCTTTTTCCCTTACCCAGAA ATGAAAATACTCAATATGGACCATTTAGGAATTATAAGCAGCAACTGTGAAAGACTTGCCACTCAATATCTTAGGTGACTGATTAGACAT AGAGGGTTGTTTTAGGAGCATGCCACGGGAAAGACTGAGGGATCATGATCATTTGTTCAGAAAAAAAGCCCCTGAACTGATTTTGTTACC ATAGAATTTAAAAAAAAAAAAAGCTTTAACAGTTGGCTGTAATTTGGCTTTTATTATCCTTTATTAAAATACAAATGTCAATGCTTTTCC TGCCTTTTTAATACCATGTCAGTGTAACATAGGTATTTATTTTGCTCATCCCTGTGATCTGTGCATTTTTGCTGCGTGGATGTGATTGTT TGGTTTCAGTTAGAAACGTCATAGATTTGCTGTTTGAATATGCCAAGGTGGGGACTTAGACATTATGTACGTCTCACAAATCCTACCTGC ATACCAGTCAGCTCTATTGAGGAAGACAATGTAAAACTAATGTAAACTACAGTTTGCATTTCCCTGAAAACAGAATATTGTTTTTAAGAG GGTTAGAAACAACCAGTGGGAAAGGCACATGCTGCTTTGTTTAGTTTTTCCTTGTTCAAACTTTGTTGGTCACATTTTCCCATCTGTATT CTTTTTTATTAAGAAAACAGCTTAGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTCCGAGGTTGCTACAAAAACACCATTGCA CTCTGGCCTGGACAACAGAGAGACCCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAAAATTCTACTTGTACCTTATTCCCTATGAGAATAC TTATCAAACTTATCTAAAAAAGAAAAATAGGAACAGCCATATGCAAAGTCAGCCCAACAGGAAAGGACATATTAGATTAAAATACATTGC GGCCTGGGCTTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCGCTTGAGTCCAGGAGTCGAAACCCTGT CTCTACAAAAAAAAAAATACAAAAATCTGCCTGTTGTCCCAGCCACTGGGGAGGCTGAGGTAGGAGGTCAAGGCTGCAGTGAACCTTGAT CATTGCTACTGCCACTCCAGCCTAGGTGACAGAGTGAGACCCTGTCTCCAAAAAAAAAAGTGTATATGTATGTGTGTATATATAGCAAGA GAGAGTTCTGTGATCAATTGAAGGCAAAAACAGTAACACTGAGAGGGGCTTTGCTTCCCTTCCTGAAGATCATGTCATTGGGGTGGGTTC CTGTAAAGGGAATTTTCCAAGAGAAAAGAGAATTTTCATGACCTGTAGACTCTTACAAATCCATTTTACCTGCTTCCTTATGGTATGTTT ATTCAAAGCACCTGTGTACCATATTTATTCACTTACACAGCATTACTGAATCTGGAAATTTTCAGTTAGGTATATTTTACATAATTCCCA CCCATATAACTCAGTCCATACAGTTCACAGTTTTCATTCCCTCATAGCAATGCAAAAAATTTTGATGAGTTACTACTACTAAAACTAGTT AAGTAAAAGATGATTCTTAAGAATTTCCAGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGCT CACGAGGTCAGGAGATCGAGACCATCCTGCTCGGTGAAACCCCATCTCTATTAAAAATACAAAAAATTAGCCGGGCCTGGTGGCGGGTGC CTGTAGTCCCATCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTAAGCTGAGATTGTGCCACTGC ACTCCAGCCTGGGCGACAGAGGGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAATGAATTTCCAGCTATACCAAAATGTTACTAATGT ATCTTATATTTCAGGCATGTCTAAATCAACTTTTAGTATGCCTCAGGCATTTGTCACCAACCTTTTATATTAACATGAAACTTAGAAAAT TTTTGATAGAATCCCAGAGTTCAAAAGGTATTAGGATTTTTGCCACTGAAGTAAAAAAGAGAAAAAAAGATATTTATGAGAAAACTATTG AACAGTGACTGTGTTGTACCCGAGCAAGTTAGAGGAACGCCACACTTTGAGACGAATTTAAAAGTCCTTTATTTAGCTGGCAGCCAAGAG GTGGCTCACACTTGGAATTCTCTCAGCTCCGAGGAAGGGGCTTGATTTTCCTTTATACTTTGGTTTAGGAAGGGGACGGGAGCTCAGTTG CAACAATTCTACAGAAGTAAAAACATGCAAAAAATTAAAAAGACAAATGGTTACAGAGAAACAAACAGTTCCAGGTGCAGGGGCTCTAAA TCTATCATAAGATGTCAGGTGTGGGGGCTCTGCCAGACACAAACTCAAGGCTTTATGGTGTATCTCTTGAGCGAAATCCTGGGAACTTCG TACATTGCTTGCTTCAGTACCTTATGAGTTAATTGGACTCTTTGATATGTTGAGAGTCAGCTTACACAAGTTAACTCCTTGAGGAAAGGG GGTGGGTAAGGAGTCCTTGATGTCCTGTAAATGAAGGAACCAAATGGAGTTCCTCCGGCTTTCTCAGCTAAGGGAGAGCTTATTCACATG GAAACAAGGCTAGGTGATTAAGGGAGAAAGGGACAGTCTGAAAACAAGGTTAGTAAAAACAAGGTTAGGTATTAGAACTGCAAAGAGTAT TAAGTGAAATAAGTGAAGGAAAATATGAGCTCTTATTTTTAAAAAGTTGTGTTGGGGCAAATGTTAAATATCTTTCTTTCTCTGGACATT ATTAAGAAAGATAGAGTGATGTGAATGATAGGAAGCCCACCTGTAACCACTTAGCTGACATGTCCAACTATGGGTGAACAGGAAATAAGC GACATTCACCTAGGCTGTTTATTGGAATCTGACTAGCATTATTTGATTTGGCATACTTTACATGTCCAGAACAAGGCTGTTGGTGCTTGG CACCAAGAAATTTATGACTTTTTTTTTTTTTTTAAATAAAGTCCTAAAGGTAGCATTAAAATGACTTAACTGGAGGCAGGAGGATCACTG AAGCCCAGGAGTTTGAAGCTGCAGTAAGCTAAGAAGGTGCCACTGCACTGCAGCCTGGATGACAGAGTGAAACTTTGTCTCTTAATAGAA CTATGGACTGAAGTTGTGATATTGAGTGTTATATTTCTCAATAAAGGTTTTTTCTTTTAATACTGTATTAGGTCAAATTCAAGGTCTTAA TTCCTTGAATTCCAATTTCCTTGTGAAATTTCATGTGATTAATTTAAAATTCCAGGGATCCTATCTAACATCACAGTTGATGGATATAAC AATGTATTTTGAGAAATCAGTTTTGGTGAACAGTAACAGCATTACTGATAATAGGCAACAAACACTACTGCATTTTATTTCTGATAGGCA TTATAGGTGGTAATCCAAATGATTAATGATTTTATTGCTCTTTACATTTTCTAGAACAGGTGATTTGACATAATTGTACTTTTTTCTGAG AAGTTGGTAGTGTACTTACTACTCTATTTTGCAGTTATACAATAAATCTTACTTAGCTGACAACTAGGAGTAAAAGCTCTGACAAAAAGC CTCTGCTGTAACTAAAATACTGAGATCATTCTATCTTAACAAACTTAACAGATGGGGAAGGGGTATATTTTAAAGATGGAGAAATGATGC AGTTTGCAAATATAGTCAATAAATATTCTCAAGTGTACGTAGCTCAATTTCATTTGCAGCAAAGATAACACTGAAATGTCTATGGATGAG ATTATTGGATAAACTTTTTTAAAAACACTGTTCTCAAGATAGGCAAGTGATTAAGAGCACTGACTGGGCCGGGCGCGGTGGCTCACGTCT ATAATCCTAGCACTTTGGGAGGCCGAGGCGGGCAAATCACAAGGTCAGGAGATCAAAACAATCCTGGCTAACAAGGTGAAACCCCGTCTC TACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGTGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGTAAT CCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCGGGGTGACAGAGCGAGACTCCCACCCATCTCAAAAAAA ATAAAAATGAAAAGCACTGATTGAATCTAGATTCCTTGAGTCCAAGTGTCAGATCTCTGCTTACTAGCTCTGGGATCTCAGATGTTTCGT TGATTGGATTTCTTTGTGCTCATTTGTGTAAACAGGAATGCCCGTCTTTAAAGACTATTAAAATGAATGTGAGTTAACACACAAGAGGTC TTCAAAAAGTTGATGGAAAATGCATATTATGAAAAAAATTATGCATAGATTTCAAAAATCTTTGCAGCAAAATAAACTCATCATTATAAC ATGTCTGAACAGGATCTAGTTTGAGGCACTAAGAAGGATATCAGTTTAAATAGAGCCCCTGTCAGAACAATATGAATTCTGCTAAAACTG AAGCAAGAACAAACATCAAATTTATGGCAAAGCTTAGGTGGAAGAATGGTGCAATCATTGATGCTTTGCAAAAAGTTTATGGGAACAACG CCCCAAGGAAATCAGTTTACAAATGGATAATTCATTTTAAGAAAGGACAAGACAATGTTGAAGATGAAACCTACAGCAGCAGACCATGCC ACTTCGTGAGGAAAAAATTATCTCATTCATGCCCTACTTGAAGAGGACCAATGATTAACAGCAGAAACGATAGCCAACACAATATGCTCC TCAGTTGGTTCAGCTTTTATAAATCTGACTGAAAAATTAAAGTTGAGCACACTTTCCACTCAATGGATACCAAAACCATCCAGCCCAGGT CAGCTGCAGACAAAAGCAGAGCTTTCGATGGAAATGTCAAACAAGTGAGATCAAGATCCTGAAGCATTTCTTCAAAGAATTGTAGCAAAA ACAGACTTTTAAAACCTTGAATTCAGAGACAGGTATAAAGACTGCTTGGTGATTTTGAAAGGACTGAGATCATTTTGGGAGAGATCATCT TCAGAAAATGACCAGATACAACAAGAATTTAACATGGCAGCCAAACCAACCCACTAACACACATTTAAATAAGATACCCAAATGCAGAAA GAAAAGCACAGTCGTCATGCAAAATAGTCACTACTCATTCAAAAACTCTATAGTTGTCTGAGTCGTTATGCTCAAAATATCCAATAATAT TTCTTTTGCTGAGCTGTAAAATAATTATTTTGCAAACATAAAAGAAAAAAAAAAGAATTGTAACAGAAACATGGCTTTACCAGTATGACC CTCAAGACAAAATACAAAACAATGGCTACCAAGAGGTGGAAGTGGCCCAGTCACAGCAAGAGCAGATTGATCAAGAGCAAAGGTCATGGT AACAGTTTTTTGGATCCTCAAGTCATTTTGCTTGTTGACTTTTTGGAGGGCCAAATAAAGATATCATCTGCTTATTATGAGAGTGTTTCG AGAGAAATCCAAAGCTTAGCAGAGAAACGCCTGGGAAAGCTTCACCAGAGGGTCTTCCACCGTGACAGTTCCCCTGCGCATTCCTCTCAT AAAGCAAGGGCAGTTTAGCTAGAATTTCTATCAAAAATCATTAGGTATCCATCTCCCAGTCCTGATTTGGCTCCTTCTGACTTCTTTTTG TTTCCCAATCTTAAAAAAATCCCTGAAGGGCACCTGTTTTTCTTCAGCTAATAAAAAAGACATGGTTAATTTCCCAGGACCCTCAGTTCT TTAGGGATAGACTGAATGGCTGGTATCATTGCTTGAACTTAATGGAGCTTATGTTGAGAAATAAAAGAAATTATATTTTATTTTTATCTT TTAATTCTATTTTTCCATGAACTTTTTGAAGTCCCCTCAGATATAAAGCAGAACGTTATGAAACTGAGTTACCTTGAATCTAGAAGAGTA CAATGATAAAGGGGAAGATAGAAACACACACATATGCGTTGTTTTCCCCACTTTCACAATGCCGTGCAGAAACTAACAGATGAAGGAGGA GAATCCCTAAAAACAGAGCATTGGGTAGCTAGTCCACCAGCGGTCTGATGCTTTCATTGATCTCAAAACTGTCTCTGAGTAACTCTACCA GGAAAGTTGTCTGGAGGGTTAACATTTCTGAAACCATTTTTATCTTTGCCTTCATTCTTGAATGATAATTAGTCTCGAATGTTTGGATCA CAATCCATTGAAAGACTAGGCTATTTTTTCACTGTCCTCAGACATTTACTGAGTCCAGTTTGGACTTTATTTTATTTTATTTTTTTTGAA ACAAGATCTCGCTCTGTTGCTCAGGCTGAAGTGCAATAGCGCAAACTCGGCTCACTGCAACCTCCCAGGTTCAAGCAATTCTCGTGCCTC AGCCATCCCTATAGGCATGCGCCACCACACTTTGCTAATCTTGTATTTTTGGTAGAGACGGGGTTTGCACCATGTTGGCCAGGCTGGTCT CGAACTCCCAACCTCAAGTAATCTGGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCAGCGCGCCCGGCCTGGACTTAACTTCTGAAG AACTCTTTCTGTTTAGATTGCAGGAGCGTTCTCTCGGCTCATCTCTTGTTTTCTCACCCAGCTGTTCTTCTTCTAGTTGGCCATCATTCT TCATCCCTCCCTCCCTTTCCTGCAGTTAATTATTTCTTTGAAATTTTAAAACTTCTTAATGTTGCCTGGAATACATGAGTCTTCCTGATC TCTTCAAACGGGGTTTGTTTTGTTTTGCTTTGGGGAGAATTCTTTTGACGTTTTTGAATAAGCTGTTAACAACTTTAATACCTGTCTTGT TTGTTTTCTTCAGAAATTTGTTAATTCTCCATGATTAGCACCTTTATGTGGTTATCTCATTATTTTCATTCCTTTTTAATTCTCTGTTTT AGGAATGCTTGTCAAATTCGTCACTAAAATTGATTTACTTTCTTGAAAACCTGTTTCTGCTGCTCCCAACATGATTTAATCTTGGCTACT GAGCTTTTGGTTACGTTGCACTCCCTTTAAAATTACTCCGTTTAAGTACAGTGTTCACTCTTTGGGTAATGTGTACAATAGAAGCCCAAT >In-frame_VTI1A_ENST00000393077_chr10_114298089_+_GTF2H5_ENST00000607778_chr6_158613009_+_7911nt CCGTTCTGCTCTCGGGGGCACCTTCCGGGGTTCCTAAGCCGCGGGGCCCCTCGCTGCCCCTCGAGGCCCTTTCCCTGACCTAGGCTTTGG CCTGGGCTACTCGTTCCGGAGCCGCCATGTCGTCCGACTTCGAAGGTTACGAGCAGGACTTCGCGGTGCTCACTGCAGAGATCACCAGCA AGATTGCGAGGGTCCCACGACTCCCGCCTGATGAAAAGAAACAGATGGTTGCAAATGTGGAGAAACAGCTTGAAGAAGCGAAAGAACTGC TTGAACAGATGGATTTGGAAGTCCGAGAGATACCACCCCAAAGTCGAGGGATGTACAGCAACAGAATGAGAAGCTACAAACAAGAAATGG GAAAACTCGAAACAGATTTTAAAAGGTCACGGATCGCCTACAGTGACGAAGTACGGAATGAGCTCCTGGGGGATGATGGGAATTCCTCAG AGAACCAGAGGGCACATCTGCTCGATAACACAGAGAGGCTGGAAAGGTCATCTCGGAGACTAGAGGCTGGATACCAAATAGCAGTGGAAA CCGTGATCCTGCCATGAAGCAGTTTCTGCTGTACTTGGATGAGTCCAATGCCCTGGGGAAGAAGTTCATCATTCAAGACATTGATGACAC TCACGTCTTTGTAATAGCAGAATTGGTTAATGTCCTCCAGGAGCGAGTGGGTGAATTAATGGACCAAAATGCTTTTTCCCTTACCCAGAA ATGAAAATACTCAATATGGACCATTTAGGAATTATAAGCAGCAACTGTGAAAGACTTGCCACTCAATATCTTAGGTGACTGATTAGACAT AGAGGGTTGTTTTAGGAGCATGCCACGGGAAAGACTGAGGGATCATGATCATTTGTTCAGAAAAAAAGCCCCTGAACTGATTTTGTTACC ATAGAATTTAAAAAAAAAAAAAGCTTTAACAGTTGGCTGTAATTTGGCTTTTATTATCCTTTATTAAAATACAAATGTCAATGCTTTTCC TGCCTTTTTAATACCATGTCAGTGTAACATAGGTATTTATTTTGCTCATCCCTGTGATCTGTGCATTTTTGCTGCGTGGATGTGATTGTT TGGTTTCAGTTAGAAACGTCATAGATTTGCTGTTTGAATATGCCAAGGTGGGGACTTAGACATTATGTACGTCTCACAAATCCTACCTGC ATACCAGTCAGCTCTATTGAGGAAGACAATGTAAAACTAATGTAAACTACAGTTTGCATTTCCCTGAAAACAGAATATTGTTTTTAAGAG GGTTAGAAACAACCAGTGGGAAAGGCACATGCTGCTTTGTTTAGTTTTTCCTTGTTCAAACTTTGTTGGTCACATTTTCCCATCTGTATT CTTTTTTATTAAGAAAACAGCTTAGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTCCGAGGTTGCTACAAAAACACCATTGCA CTCTGGCCTGGACAACAGAGAGACCCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAAAATTCTACTTGTACCTTATTCCCTATGAGAATAC TTATCAAACTTATCTAAAAAAGAAAAATAGGAACAGCCATATGCAAAGTCAGCCCAACAGGAAAGGACATATTAGATTAAAATACATTGC GGCCTGGGCTTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCGCTTGAGTCCAGGAGTCGAAACCCTGT CTCTACAAAAAAAAAAATACAAAAATCTGCCTGTTGTCCCAGCCACTGGGGAGGCTGAGGTAGGAGGTCAAGGCTGCAGTGAACCTTGAT CATTGCTACTGCCACTCCAGCCTAGGTGACAGAGTGAGACCCTGTCTCCAAAAAAAAAAGTGTATATGTATGTGTGTATATATAGCAAGA GAGAGTTCTGTGATCAATTGAAGGCAAAAACAGTAACACTGAGAGGGGCTTTGCTTCCCTTCCTGAAGATCATGTCATTGGGGTGGGTTC CTGTAAAGGGAATTTTCCAAGAGAAAAGAGAATTTTCATGACCTGTAGACTCTTACAAATCCATTTTACCTGCTTCCTTATGGTATGTTT ATTCAAAGCACCTGTGTACCATATTTATTCACTTACACAGCATTACTGAATCTGGAAATTTTCAGTTAGGTATATTTTACATAATTCCCA CCCATATAACTCAGTCCATACAGTTCACAGTTTTCATTCCCTCATAGCAATGCAAAAAATTTTGATGAGTTACTACTACTAAAACTAGTT AAGTAAAAGATGATTCTTAAGAATTTCCAGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGCT CACGAGGTCAGGAGATCGAGACCATCCTGCTCGGTGAAACCCCATCTCTATTAAAAATACAAAAAATTAGCCGGGCCTGGTGGCGGGTGC CTGTAGTCCCATCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTAAGCTGAGATTGTGCCACTGC ACTCCAGCCTGGGCGACAGAGGGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAATGAATTTCCAGCTATACCAAAATGTTACTAATGT ATCTTATATTTCAGGCATGTCTAAATCAACTTTTAGTATGCCTCAGGCATTTGTCACCAACCTTTTATATTAACATGAAACTTAGAAAAT TTTTGATAGAATCCCAGAGTTCAAAAGGTATTAGGATTTTTGCCACTGAAGTAAAAAAGAGAAAAAAAGATATTTATGAGAAAACTATTG AACAGTGACTGTGTTGTACCCGAGCAAGTTAGAGGAACGCCACACTTTGAGACGAATTTAAAAGTCCTTTATTTAGCTGGCAGCCAAGAG GTGGCTCACACTTGGAATTCTCTCAGCTCCGAGGAAGGGGCTTGATTTTCCTTTATACTTTGGTTTAGGAAGGGGACGGGAGCTCAGTTG CAACAATTCTACAGAAGTAAAAACATGCAAAAAATTAAAAAGACAAATGGTTACAGAGAAACAAACAGTTCCAGGTGCAGGGGCTCTAAA TCTATCATAAGATGTCAGGTGTGGGGGCTCTGCCAGACACAAACTCAAGGCTTTATGGTGTATCTCTTGAGCGAAATCCTGGGAACTTCG TACATTGCTTGCTTCAGTACCTTATGAGTTAATTGGACTCTTTGATATGTTGAGAGTCAGCTTACACAAGTTAACTCCTTGAGGAAAGGG GGTGGGTAAGGAGTCCTTGATGTCCTGTAAATGAAGGAACCAAATGGAGTTCCTCCGGCTTTCTCAGCTAAGGGAGAGCTTATTCACATG GAAACAAGGCTAGGTGATTAAGGGAGAAAGGGACAGTCTGAAAACAAGGTTAGTAAAAACAAGGTTAGGTATTAGAACTGCAAAGAGTAT TAAGTGAAATAAGTGAAGGAAAATATGAGCTCTTATTTTTAAAAAGTTGTGTTGGGGCAAATGTTAAATATCTTTCTTTCTCTGGACATT ATTAAGAAAGATAGAGTGATGTGAATGATAGGAAGCCCACCTGTAACCACTTAGCTGACATGTCCAACTATGGGTGAACAGGAAATAAGC GACATTCACCTAGGCTGTTTATTGGAATCTGACTAGCATTATTTGATTTGGCATACTTTACATGTCCAGAACAAGGCTGTTGGTGCTTGG CACCAAGAAATTTATGACTTTTTTTTTTTTTTTAAATAAAGTCCTAAAGGTAGCATTAAAATGACTTAACTGGAGGCAGGAGGATCACTG AAGCCCAGGAGTTTGAAGCTGCAGTAAGCTAAGAAGGTGCCACTGCACTGCAGCCTGGATGACAGAGTGAAACTTTGTCTCTTAATAGAA CTATGGACTGAAGTTGTGATATTGAGTGTTATATTTCTCAATAAAGGTTTTTTCTTTTAATACTGTATTAGGTCAAATTCAAGGTCTTAA TTCCTTGAATTCCAATTTCCTTGTGAAATTTCATGTGATTAATTTAAAATTCCAGGGATCCTATCTAACATCACAGTTGATGGATATAAC AATGTATTTTGAGAAATCAGTTTTGGTGAACAGTAACAGCATTACTGATAATAGGCAACAAACACTACTGCATTTTATTTCTGATAGGCA TTATAGGTGGTAATCCAAATGATTAATGATTTTATTGCTCTTTACATTTTCTAGAACAGGTGATTTGACATAATTGTACTTTTTTCTGAG AAGTTGGTAGTGTACTTACTACTCTATTTTGCAGTTATACAATAAATCTTACTTAGCTGACAACTAGGAGTAAAAGCTCTGACAAAAAGC CTCTGCTGTAACTAAAATACTGAGATCATTCTATCTTAACAAACTTAACAGATGGGGAAGGGGTATATTTTAAAGATGGAGAAATGATGC AGTTTGCAAATATAGTCAATAAATATTCTCAAGTGTACGTAGCTCAATTTCATTTGCAGCAAAGATAACACTGAAATGTCTATGGATGAG ATTATTGGATAAACTTTTTTAAAAACACTGTTCTCAAGATAGGCAAGTGATTAAGAGCACTGACTGGGCCGGGCGCGGTGGCTCACGTCT ATAATCCTAGCACTTTGGGAGGCCGAGGCGGGCAAATCACAAGGTCAGGAGATCAAAACAATCCTGGCTAACAAGGTGAAACCCCGTCTC TACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGTGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGTAAT CCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCGGGGTGACAGAGCGAGACTCCCACCCATCTCAAAAAAA ATAAAAATGAAAAGCACTGATTGAATCTAGATTCCTTGAGTCCAAGTGTCAGATCTCTGCTTACTAGCTCTGGGATCTCAGATGTTTCGT TGATTGGATTTCTTTGTGCTCATTTGTGTAAACAGGAATGCCCGTCTTTAAAGACTATTAAAATGAATGTGAGTTAACACACAAGAGGTC TTCAAAAAGTTGATGGAAAATGCATATTATGAAAAAAATTATGCATAGATTTCAAAAATCTTTGCAGCAAAATAAACTCATCATTATAAC ATGTCTGAACAGGATCTAGTTTGAGGCACTAAGAAGGATATCAGTTTAAATAGAGCCCCTGTCAGAACAATATGAATTCTGCTAAAACTG AAGCAAGAACAAACATCAAATTTATGGCAAAGCTTAGGTGGAAGAATGGTGCAATCATTGATGCTTTGCAAAAAGTTTATGGGAACAACG CCCCAAGGAAATCAGTTTACAAATGGATAATTCATTTTAAGAAAGGACAAGACAATGTTGAAGATGAAACCTACAGCAGCAGACCATGCC ACTTCGTGAGGAAAAAATTATCTCATTCATGCCCTACTTGAAGAGGACCAATGATTAACAGCAGAAACGATAGCCAACACAATATGCTCC TCAGTTGGTTCAGCTTTTATAAATCTGACTGAAAAATTAAAGTTGAGCACACTTTCCACTCAATGGATACCAAAACCATCCAGCCCAGGT CAGCTGCAGACAAAAGCAGAGCTTTCGATGGAAATGTCAAACAAGTGAGATCAAGATCCTGAAGCATTTCTTCAAAGAATTGTAGCAAAA ACAGACTTTTAAAACCTTGAATTCAGAGACAGGTATAAAGACTGCTTGGTGATTTTGAAAGGACTGAGATCATTTTGGGAGAGATCATCT TCAGAAAATGACCAGATACAACAAGAATTTAACATGGCAGCCAAACCAACCCACTAACACACATTTAAATAAGATACCCAAATGCAGAAA GAAAAGCACAGTCGTCATGCAAAATAGTCACTACTCATTCAAAAACTCTATAGTTGTCTGAGTCGTTATGCTCAAAATATCCAATAATAT TTCTTTTGCTGAGCTGTAAAATAATTATTTTGCAAACATAAAAGAAAAAAAAAAGAATTGTAACAGAAACATGGCTTTACCAGTATGACC CTCAAGACAAAATACAAAACAATGGCTACCAAGAGGTGGAAGTGGCCCAGTCACAGCAAGAGCAGATTGATCAAGAGCAAAGGTCATGGT AACAGTTTTTTGGATCCTCAAGTCATTTTGCTTGTTGACTTTTTGGAGGGCCAAATAAAGATATCATCTGCTTATTATGAGAGTGTTTCG AGAGAAATCCAAAGCTTAGCAGAGAAACGCCTGGGAAAGCTTCACCAGAGGGTCTTCCACCGTGACAGTTCCCCTGCGCATTCCTCTCAT AAAGCAAGGGCAGTTTAGCTAGAATTTCTATCAAAAATCATTAGGTATCCATCTCCCAGTCCTGATTTGGCTCCTTCTGACTTCTTTTTG TTTCCCAATCTTAAAAAAATCCCTGAAGGGCACCTGTTTTTCTTCAGCTAATAAAAAAGACATGGTTAATTTCCCAGGACCCTCAGTTCT TTAGGGATAGACTGAATGGCTGGTATCATTGCTTGAACTTAATGGAGCTTATGTTGAGAAATAAAAGAAATTATATTTTATTTTTATCTT TTAATTCTATTTTTCCATGAACTTTTTGAAGTCCCCTCAGATATAAAGCAGAACGTTATGAAACTGAGTTACCTTGAATCTAGAAGAGTA CAATGATAAAGGGGAAGATAGAAACACACACATATGCGTTGTTTTCCCCACTTTCACAATGCCGTGCAGAAACTAACAGATGAAGGAGGA GAATCCCTAAAAACAGAGCATTGGGTAGCTAGTCCACCAGCGGTCTGATGCTTTCATTGATCTCAAAACTGTCTCTGAGTAACTCTACCA GGAAAGTTGTCTGGAGGGTTAACATTTCTGAAACCATTTTTATCTTTGCCTTCATTCTTGAATGATAATTAGTCTCGAATGTTTGGATCA CAATCCATTGAAAGACTAGGCTATTTTTTCACTGTCCTCAGACATTTACTGAGTCCAGTTTGGACTTTATTTTATTTTATTTTTTTTGAA ACAAGATCTCGCTCTGTTGCTCAGGCTGAAGTGCAATAGCGCAAACTCGGCTCACTGCAACCTCCCAGGTTCAAGCAATTCTCGTGCCTC AGCCATCCCTATAGGCATGCGCCACCACACTTTGCTAATCTTGTATTTTTGGTAGAGACGGGGTTTGCACCATGTTGGCCAGGCTGGTCT CGAACTCCCAACCTCAAGTAATCTGGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCAGCGCGCCCGGCCTGGACTTAACTTCTGAAG AACTCTTTCTGTTTAGATTGCAGGAGCGTTCTCTCGGCTCATCTCTTGTTTTCTCACCCAGCTGTTCTTCTTCTAGTTGGCCATCATTCT TCATCCCTCCCTCCCTTTCCTGCAGTTAATTATTTCTTTGAAATTTTAAAACTTCTTAATGTTGCCTGGAATACATGAGTCTTCCTGATC TCTTCAAACGGGGTTTGTTTTGTTTTGCTTTGGGGAGAATTCTTTTGACGTTTTTGAATAAGCTGTTAACAACTTTAATACCTGTCTTGT TTGTTTTCTTCAGAAATTTGTTAATTCTCCATGATTAGCACCTTTATGTGGTTATCTCATTATTTTCATTCCTTTTTAATTCTCTGTTTT AGGAATGCTTGTCAAATTCGTCACTAAAATTGATTTACTTTCTTGAAAACCTGTTTCTGCTGCTCCCAACATGATTTAATCTTGGCTACT GAGCTTTTGGTTACGTTGCACTCCCTTTAAAATTACTCCGTTTAAGTACAGTGTTCACTCTTTGGGTAATGTGTACAATAGAAGCCCAAT |
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FusionGenePPI for VTI1A_GTF2H5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
VTI1A | VAMP4, VAMP3, STX7, STX8, VAMP8, TMBIM6, STX6, STX12, CLEC12A, HAUS1 | GTF2H5 | CDK7, ERCC3, GTF2H2, UNK, CCNH, ERCC2, ERCC5, GTF2H1, GTF2H3, GTF2H4, ITPR1, MNAT1, NUP98, PPP1R2, RNF40, HARS2, CDCA3, GTF2H2C_2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VTI1A_GTF2H5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VTI1A_GTF2H5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VTI1A | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | VTI1A | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | GTF2H5 | C4017171 | TRICHOTHIODYSTROPHY 3, PHOTOSENSITIVE | 1 | UNIPROT |