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Fusion gene ID: 41662 |
FusionGeneSummary for VRK2_CREM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VRK2_CREM | Fusion gene ID: 41662 | Hgene | Tgene | Gene symbol | VRK2 | CREM | Gene ID | 7444 | 1390 |
| Gene name | vaccinia related kinase 2 | cAMP responsive element modulator | |
| Synonyms | - | CREM-2|ICER|hCREM-2 | |
| Cytomap | 2p16.1 | 10p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase VRK2vaccinia virus B1R-related kinase 2 | cAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICER | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q86Y07 | Q03060 | |
| Ensembl transtripts involved in fusion gene | ENST00000435505, ENST00000417641, ENST00000478687, ENST00000412104, ENST00000340157, ENST00000440705, | ENST00000474362, ENST00000374721, ENST00000489388, ENST00000374726, ENST00000429130, ENST00000469949, ENST00000460270, ENST00000354759, ENST00000489321, ENST00000395895, ENST00000374728, ENST00000345491, ENST00000333809, ENST00000439705, ENST00000337656, ENST00000374734, ENST00000479070, ENST00000348787, ENST00000361599, ENST00000484283, ENST00000395887, ENST00000463314, ENST00000342105, ENST00000463960, ENST00000487763, ENST00000473940, ENST00000488328, ENST00000356917, ENST00000488741, ENST00000474931, ENST00000468236, ENST00000344351, ENST00000490511, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 6 X 4=168 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VRK2 [Title/Abstract] AND CREM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VRK2 | GO:0046777 | protein autophosphorylation | 14645249|16704422 |
| Tgene | CREM | GO:0006355 | regulation of transcription, DNA-templated | 8206879 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW853696 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000435505 | ENST00000474362 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000374721 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000489388 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000374726 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000429130 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000469949 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000460270 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000354759 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000489321 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000395895 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000374728 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000345491 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000333809 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000439705 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000337656 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000374734 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000479070 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000348787 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000361599 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000484283 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000395887 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000463314 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000342105 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000463960 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000487763 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000473940 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000488328 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000356917 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000488741 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000474931 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000468236 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000344351 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000435505 | ENST00000490511 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000474362 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000374721 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000489388 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000374726 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000429130 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000469949 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000460270 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000354759 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000489321 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000395895 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000374728 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000345491 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000333809 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000439705 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000337656 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000374734 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000479070 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000348787 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000361599 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000484283 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000395887 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000463314 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000342105 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000463960 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000487763 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000473940 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000488328 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000356917 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000488741 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000474931 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000468236 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000344351 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000417641 | ENST00000490511 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000474362 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000374721 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000489388 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000374726 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000429130 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000469949 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000460270 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000354759 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000489321 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000395895 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000374728 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000345491 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000333809 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000439705 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000337656 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000374734 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000479070 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000348787 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000361599 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000484283 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000395887 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000463314 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000342105 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000463960 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000487763 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000473940 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000488328 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000356917 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000488741 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000474931 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000468236 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000344351 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000478687 | ENST00000490511 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000474362 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000374721 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000489388 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000374726 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000429130 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000469949 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000460270 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000354759 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000489321 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000395895 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000374728 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000345491 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000333809 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000439705 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000337656 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000374734 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000479070 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000348787 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000361599 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000484283 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000395887 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000463314 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000342105 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000463960 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000487763 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000473940 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000488328 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000356917 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000488741 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000474931 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000468236 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000344351 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000412104 | ENST00000490511 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000474362 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000374721 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000489388 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000374726 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000429130 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000469949 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000460270 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000354759 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000489321 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000395895 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000374728 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000345491 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000333809 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000439705 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000337656 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000374734 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000479070 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000348787 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000361599 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000484283 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000395887 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000463314 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000342105 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000463960 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000487763 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000473940 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000488328 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000356917 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000488741 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000474931 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000468236 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000344351 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000340157 | ENST00000490511 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000474362 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000374721 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000489388 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000374726 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000429130 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000469949 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000460270 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000354759 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000489321 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000395895 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000374728 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000345491 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000333809 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000439705 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000337656 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000374734 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000479070 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000348787 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000361599 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000484283 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000395887 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000463314 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000342105 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000463960 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000487763 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000473940 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000488328 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000356917 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000488741 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000474931 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000468236 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000344351 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
| intron-intron | ENST00000440705 | ENST00000490511 | VRK2 | chr2 | 58283268 | - | CREM | chr10 | 35471143 | - |
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FusionProtFeatures for VRK2_CREM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VRK2 | CREM |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VRK2_CREM |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VRK2_CREM |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VRK2_CREM |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VRK2_CREM |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | VRK2 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | CREM | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | CREM | C0011875 | Diabetic Angiopathies | 1 | CTD_human |
| Tgene | CREM | C0020564 | Hypertrophy | 1 | CTD_human |
| Tgene | CREM | C0027051 | Myocardial Infarction | 1 | CTD_human |
| Tgene | CREM | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CREM | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | CREM | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| Tgene | CREM | C0263454 | Chloracne | 1 | CTD_human |
| Tgene | CREM | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | CREM | C3495559 | Juvenile arthritis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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