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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41638

FusionGeneSummary for VPS72_MUC4

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS72_MUC4
Fusion gene ID: 41638
HgeneTgene
Gene symbol

VPS72

MUC4

Gene ID

6944

4585

Gene namevacuolar protein sorting 72 homologmucin 4, cell surface associated
SynonymsCFL1|Swc2|TCFL1|YL-1|YL1ASGP|HSA276359|MUC-4
Cytomap

1q21.3

3q29

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 72 homologtranscription factor-like 1transformation suppressor gene YL-1mucin-4ascites sialoglycoproteinmucin 4, tracheobronchialpancreatic adenocarcinoma mucintestis mucintracheobronchial mucin
Modification date2018052320180522
UniProtAcc

Q15906

Q99102

Ensembl transtripts involved in fusion geneENST00000354473, ENST00000496809, 
ENST00000346145, ENST00000349607, 
ENST00000463781, ENST00000475231, 
ENST00000478685, 
Fusion gene scores* DoF score8 X 7 X 4=2245 X 5 X 1=25
# samples 86
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VPS72 [Title/Abstract] AND MUC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG015132VPS72chr1

151149497

+MUC4chr3

195515498

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000354473ENST00000346145VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000354473ENST00000349607VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000354473ENST00000463781VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000354473ENST00000475231VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000354473ENST00000478685VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000496809ENST00000346145VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000496809ENST00000349607VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000496809ENST00000463781VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000496809ENST00000475231VPS72chr1

151149497

+MUC4chr3

195515498

+
intron-intronENST00000496809ENST00000478685VPS72chr1

151149497

+MUC4chr3

195515498

+

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FusionProtFeatures for VPS72_MUC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VPS72

Q15906

MUC4

Q99102

Deposition-and-exchange histone chaperone specific forH2AFZ, specifically chaperones H2AFZ and deposits it intonucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomalH2A/H2B, leading to transcriptional regulation of selected genesby chromatin remodeling. {ECO:0000269|PubMed:26974126}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VPS72_MUC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VPS72_MUC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VPS72_MUC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VPS72_MUC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMUC4C0000786Spontaneous abortion1CTD_human
TgeneMUC4C0007134Renal Cell Carcinoma1CTD_human
TgeneMUC4C0033578Prostatic Neoplasms1CTD_human