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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41588

FusionGeneSummary for VPS37A_VPS37A

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS37A_VPS37A
Fusion gene ID: 41588
HgeneTgene
Gene symbol

VPS37A

VPS37A

Gene ID

137492

137492

Gene nameVPS37A, ESCRT-I subunitVPS37A, ESCRT-I subunit
SynonymsHCRP1|PQBP2|SPG53HCRP1|PQBP2|SPG53
Cytomap

8p22

8p22

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 37AESCRT-I complex subunit VPS37Ahepatocellular carcinoma-related protein 1polyglutamine binding protein 2vacuolar protein sorting 37 homolog Avacuolar protein sorting-associated protein 37AESCRT-I complex subunit VPS37Ahepatocellular carcinoma-related protein 1polyglutamine binding protein 2vacuolar protein sorting 37 homolog A
Modification date2018052220180522
UniProtAcc

Q8NEZ2

Q8NEZ2

Ensembl transtripts involved in fusion geneENST00000324849, ENST00000324815, 
ENST00000521829, ENST00000521005, 
ENST00000521162, 
ENST00000324849, 
ENST00000324815, ENST00000521829, 
ENST00000521005, ENST00000521162, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 4 X 3=48
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VPS37A [Title/Abstract] AND VPS37A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ013499VPS37Achr8

17154098

-VPS37Achr8

17154618

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000324849ENST00000324849VPS37Achr8

17154098

-VPS37Achr8

17154618

-
3UTR-intronENST00000324849ENST00000324815VPS37Achr8

17154098

-VPS37Achr8

17154618

-
3UTR-intronENST00000324849ENST00000521829VPS37Achr8

17154098

-VPS37Achr8

17154618

-
3UTR-intronENST00000324849ENST00000521005VPS37Achr8

17154098

-VPS37Achr8

17154618

-
3UTR-intronENST00000324849ENST00000521162VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-3UTRENST00000324815ENST00000324849VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000324815ENST00000324815VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000324815ENST00000521829VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000324815ENST00000521005VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000324815ENST00000521162VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-3UTRENST00000521829ENST00000324849VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521829ENST00000324815VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521829ENST00000521829VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521829ENST00000521005VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521829ENST00000521162VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-3UTRENST00000521005ENST00000324849VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521005ENST00000324815VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521005ENST00000521829VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521005ENST00000521005VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521005ENST00000521162VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-3UTRENST00000521162ENST00000324849VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521162ENST00000324815VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521162ENST00000521829VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521162ENST00000521005VPS37Achr8

17154098

-VPS37Achr8

17154618

-
intron-intronENST00000521162ENST00000521162VPS37Achr8

17154098

-VPS37Achr8

17154618

-

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FusionProtFeatures for VPS37A_VPS37A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VPS37A

Q8NEZ2

VPS37A

Q8NEZ2

Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May beinvolved in cell growth and differentiation.{ECO:0000269|PubMed:15240819}. Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May beinvolved in cell growth and differentiation.{ECO:0000269|PubMed:15240819}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VPS37A_VPS37A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VPS37A_VPS37A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VPS37A_VPS37A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VPS37A_VPS37A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVPS37AC3539494SPASTIC PARAPLEGIA 53, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT
TgeneVPS37AC3539494SPASTIC PARAPLEGIA 53, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT