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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41582

FusionGeneSummary for VPS35_TMEM189

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS35_TMEM189
Fusion gene ID: 41582
HgeneTgene
Gene symbol

VPS35

TMEM189

Gene ID

55737

387521

Gene nameVPS35, retromer complex componenttransmembrane protein 189
SynonymsMEM3|PARK17KUA
Cytomap

16q11.2

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 35hVPS35maternal-embryonic 3vacuolar protein sorting 35 homologtransmembrane protein 189
Modification date2018052320180519
UniProtAcc

Q96QK1

A5PLL7

Ensembl transtripts involved in fusion geneENST00000299138, ENST00000568642, 
ENST00000557021, ENST00000371650, 
ENST00000371652, ENST00000371656, 
Fusion gene scores* DoF score3 X 4 X 2=243 X 2 X 3=18
# samples 43
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VPS35 [Title/Abstract] AND TMEM189 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVPS35

GO:0010628

positive regulation of gene expression

26618722

HgeneVPS35

GO:0032268

regulation of cellular protein metabolic process

26618722

HgeneVPS35

GO:0045056

transcytosis

15247922

HgeneVPS35

GO:0060161

positive regulation of dopamine receptor signaling pathway

27460146

HgeneVPS35

GO:0099639

neurotransmitter receptor transport, endosome to plasma membrane

27460146


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0I9-01AVPS35chr16

46705617

-TMEM189chr20

48747484

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000299138ENST00000557021VPS35chr16

46705617

-TMEM189chr20

48747484

-
Frame-shitENST00000299138ENST00000371650VPS35chr16

46705617

-TMEM189chr20

48747484

-
Frame-shitENST00000299138ENST00000371652VPS35chr16

46705617

-TMEM189chr20

48747484

-
Frame-shitENST00000299138ENST00000371656VPS35chr16

46705617

-TMEM189chr20

48747484

-
intron-3CDSENST00000568642ENST00000557021VPS35chr16

46705617

-TMEM189chr20

48747484

-
intron-3CDSENST00000568642ENST00000371650VPS35chr16

46705617

-TMEM189chr20

48747484

-
intron-3CDSENST00000568642ENST00000371652VPS35chr16

46705617

-TMEM189chr20

48747484

-
intron-3CDSENST00000568642ENST00000371656VPS35chr16

46705617

-TMEM189chr20

48747484

-

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FusionProtFeatures for VPS35_TMEM189


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VPS35

Q96QK1

TMEM189

A5PLL7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VPS35_TMEM189


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VPS35_TMEM189


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VPS35MCC, USP43, USP32, H2AFX, FAM21C, RYK, ZBP1, IRF4, ELAVL1, ARRB2, MUL1, TBC1D5, CDK2, ANKFY1, SNX3, HGS, APP, VPS29, VPS26B, VPS26A, SNX2, TTC4, VPS36, HDLBP, TRMT61A, UPF1, VPS25, VPS33B, PPP1R14C, UBE4B, TRMT6, THUMPD3, USP48, WDR5, FN1, MAGEL2, VPS35, ZNF512B, ITGA4, IGSF8, VEGFA, ANP32E, CORO1C, FAM129B, H3F3A, NUDC, PSAP, SHMT2, SNX6, ATP6V1C1, CYHR1, IVNS1ABP, OXR1, RPL24, TOLLIP, RIOK2, ENO1, MOV10, NXF1, MRM1, MCM7, RAB7A, SLC11A2, UNK, SAC3D1, VPS13A, PCID2, SNX1, NTRK1, LCA5, SENP3, TMEM165, TSSC1, MTNR1B, FOXA1, BRCA1, AIMP2, LAMP2TMEM189UBE2N, ELAVL1, HGS, NADK2, SEPT11, NDUFV1, RBM4, OXCT1, SEC22B, PRDX6, MPST, NIT2, IQCB1, UBC, MYH11, PAX6, PPIA, MAPK3, ERP44, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VPS35_TMEM189


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VPS35_TMEM189


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVPS35C0030567Parkinson Disease1CTD_human
HgeneVPS35C0036341Schizophrenia1CTD_human
HgeneVPS35C3280133PARKINSON DISEASE 171UNIPROT