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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41581

FusionGeneSummary for VPS35_SLC6A2

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS35_SLC6A2
Fusion gene ID: 41581
HgeneTgene
Gene symbol

VPS35

SLC6A2

Gene ID

55737

6530

Gene nameVPS35, retromer complex componentsolute carrier family 6 member 2
SynonymsMEM3|PARK17NAT1|NET|NET1|SLC6A5
Cytomap

16q11.2

16q12.2

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 35hVPS35maternal-embryonic 3vacuolar protein sorting 35 homologsodium-dependent noradrenaline transporterneurotransmitter transporternorepinephrine transportersolute carrier family 6 (neurotransmitter transporter), member 2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2solute carri
Modification date2018052320180523
UniProtAcc

Q96QK1

P23975

Ensembl transtripts involved in fusion geneENST00000299138, ENST00000568642, 
ENST00000568943, ENST00000414754, 
ENST00000379906, ENST00000561820, 
ENST00000219833, ENST00000566163, 
ENST00000567238, 
Fusion gene scores* DoF score3 X 4 X 2=243 X 3 X 2=18
# samples 43
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VPS35 [Title/Abstract] AND SLC6A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVPS35

GO:0010628

positive regulation of gene expression

26618722

HgeneVPS35

GO:0032268

regulation of cellular protein metabolic process

26618722

HgeneVPS35

GO:0045056

transcytosis

15247922

HgeneVPS35

GO:0060161

positive regulation of dopamine receptor signaling pathway

27460146

HgeneVPS35

GO:0099639

neurotransmitter receptor transport, endosome to plasma membrane

27460146

TgeneSLC6A2

GO:0015844

monoamine transport

16024787


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A109-01AVPS35chr16

46702842

-SLC6A2chr16

55690556

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000299138ENST00000568943VPS35chr16

46702842

-SLC6A2chr16

55690556

+
5CDS-5UTRENST00000299138ENST00000414754VPS35chr16

46702842

-SLC6A2chr16

55690556

+
5CDS-5UTRENST00000299138ENST00000379906VPS35chr16

46702842

-SLC6A2chr16

55690556

+
5CDS-5UTRENST00000299138ENST00000561820VPS35chr16

46702842

-SLC6A2chr16

55690556

+
5CDS-5UTRENST00000299138ENST00000219833VPS35chr16

46702842

-SLC6A2chr16

55690556

+
5CDS-intronENST00000299138ENST00000566163VPS35chr16

46702842

-SLC6A2chr16

55690556

+
5CDS-intronENST00000299138ENST00000567238VPS35chr16

46702842

-SLC6A2chr16

55690556

+
intron-5UTRENST00000568642ENST00000568943VPS35chr16

46702842

-SLC6A2chr16

55690556

+
intron-5UTRENST00000568642ENST00000414754VPS35chr16

46702842

-SLC6A2chr16

55690556

+
intron-5UTRENST00000568642ENST00000379906VPS35chr16

46702842

-SLC6A2chr16

55690556

+
intron-5UTRENST00000568642ENST00000561820VPS35chr16

46702842

-SLC6A2chr16

55690556

+
intron-5UTRENST00000568642ENST00000219833VPS35chr16

46702842

-SLC6A2chr16

55690556

+
intron-intronENST00000568642ENST00000566163VPS35chr16

46702842

-SLC6A2chr16

55690556

+
intron-intronENST00000568642ENST00000567238VPS35chr16

46702842

-SLC6A2chr16

55690556

+

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FusionProtFeatures for VPS35_SLC6A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VPS35

Q96QK1

SLC6A2

P23975

Amine transporter. Terminates the action ofnoradrenaline by its high affinity sodium-dependent reuptake intopresynaptic terminals. {ECO:0000269|PubMed:2008212}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VPS35_SLC6A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VPS35_SLC6A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VPS35MCC, USP43, USP32, H2AFX, FAM21C, RYK, ZBP1, IRF4, ELAVL1, ARRB2, MUL1, TBC1D5, CDK2, ANKFY1, SNX3, HGS, APP, VPS29, VPS26B, VPS26A, SNX2, TTC4, VPS36, HDLBP, TRMT61A, UPF1, VPS25, VPS33B, PPP1R14C, UBE4B, TRMT6, THUMPD3, USP48, WDR5, FN1, MAGEL2, VPS35, ZNF512B, ITGA4, IGSF8, VEGFA, ANP32E, CORO1C, FAM129B, H3F3A, NUDC, PSAP, SHMT2, SNX6, ATP6V1C1, CYHR1, IVNS1ABP, OXR1, RPL24, TOLLIP, RIOK2, ENO1, MOV10, NXF1, MRM1, MCM7, RAB7A, SLC11A2, UNK, SAC3D1, VPS13A, PCID2, SNX1, NTRK1, LCA5, SENP3, TMEM165, TSSC1, MTNR1B, FOXA1, BRCA1, AIMP2, LAMP2SLC6A2STX1A, SNCA, ACTB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VPS35_SLC6A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC6A2P23975DB00285VenlafaxineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00289AtomoxetineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00321AmitriptylineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00344ProtriptylineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00370MirtazapineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00408LoxapineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00454PethidineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00458ImipramineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00476DuloxetineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00514DextromethorphanSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00540NortriptylineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00543AmoxapineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00696ErgotamineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00726TrimipramineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00852PseudoephedrineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00988DopamineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB01114ChlorphenamineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB01156BupropionSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB01170GuanethidineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB01173OrphenadrineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB01364EphedrineSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB06204TapentadolSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB09167DosulepinSodium-dependent noradrenaline transportersmall moleculeapproved
TgeneSLC6A2P23975DB00191PhentermineSodium-dependent noradrenaline transportersmall moleculeapproved|illicit
TgeneSLC6A2P23975DB00907CocaineSodium-dependent noradrenaline transportersmall moleculeapproved|illicit
TgeneSLC6A2P23975DB00937DiethylpropionSodium-dependent noradrenaline transportersmall moleculeapproved|illicit
TgeneSLC6A2P23975DB01576DextroamphetamineSodium-dependent noradrenaline transportersmall moleculeapproved|illicit
TgeneSLC6A2P23975DB01577MethamphetamineSodium-dependent noradrenaline transportersmall moleculeapproved|illicit
TgeneSLC6A2P23975DB00182AmphetamineSodium-dependent noradrenaline transportersmall moleculeapproved|illicit|investigational
TgeneSLC6A2P23975DB01105SibutramineSodium-dependent noradrenaline transportersmall moleculeapproved|illicit|investigational|withdrawn
TgeneSLC6A2P23975DB00193TramadolSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB00234ReboxetineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB00422MethylphenidateSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB00579MazindolSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB00715ParoxetineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB00934MaprotilineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB01142DoxepinSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB01151DesipramineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB01175EscitalopramSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB04840DebrisoquinSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB04896MilnacipranSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB06148MianserinSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB06700DesvenlafaxineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB06701DexmethylphenidateSodium-dependent noradrenaline transportersmall moleculeapproved|investigational
TgeneSLC6A2P23975DB01381Ginkgo bilobaSodium-dependent noradrenaline transportersmall moleculeapproved|investigational|nutraceutical
TgeneSLC6A2P23975DB01242ClomipramineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational|vet_approved
TgeneSLC6A2P23975DB09185ViloxazineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational|withdrawn
TgeneSLC6A2P23975DB09225ZotepineSodium-dependent noradrenaline transportersmall moleculeapproved|investigational|withdrawn
TgeneSLC6A2P23975DB01221KetamineSodium-dependent noradrenaline transportersmall moleculeapproved|vet_approved
TgeneSLC6A2P23975DB01149NefazodoneSodium-dependent noradrenaline transportersmall moleculeapproved|withdrawn

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RelatedDiseases for VPS35_SLC6A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVPS35C0030567Parkinson Disease1CTD_human
HgeneVPS35C0036341Schizophrenia1CTD_human
HgeneVPS35C3280133PARKINSON DISEASE 171UNIPROT
TgeneSLC6A2C0001973Alcoholic Intoxication, Chronic5PSYGENET
TgeneSLC6A2C0011570Mental Depression5PSYGENET
TgeneSLC6A2C0011581Depressive disorder5PSYGENET
TgeneSLC6A2C0041696Unipolar Depression5PSYGENET
TgeneSLC6A2C1269683Major Depressive Disorder5PSYGENET
TgeneSLC6A2C0005586Bipolar Disorder3PSYGENET
TgeneSLC6A2C0525045Mood Disorders3PSYGENET
TgeneSLC6A2C0036341Schizophrenia2PSYGENET
TgeneSLC6A2C0221480Recurrent depression2PSYGENET
TgeneSLC6A2C1535893Orthostatic intolerance2CTD_human;ORPHANET;UNIPROT
TgeneSLC6A2C2063866Depressive Disorder, Treatment-Resistant2PSYGENET
TgeneSLC6A2C0020538Hypertensive disease1CTD_human
TgeneSLC6A2C0036572Seizures1CTD_human