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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41505

FusionGeneSummary for VOPP1_LANCL2

check button Fusion gene summary
Fusion gene informationFusion gene name: VOPP1_LANCL2
Fusion gene ID: 41505
HgeneTgene
Gene symbol

VOPP1

LANCL2

Gene ID

81552

55915

Gene nameVOPP1, WBP1/VOPP1 family memberLanC like 2
SynonymsECOP|GASP|WBP1L2GPR69B|TASP
Cytomap

7p11.2

7p11.2

Type of geneprotein-codingprotein-coding
Descriptionvesicular, overexpressed in cancer, prosurvival protein 1EGFR-coamplified and overexpressed proteinGlioblastoma-amplified secreted proteinhypothetical protein DKFZp564K0822putative NF-kappa-B-activating protein 055NlanC-like protein 2G protein-coupled receptor 69BLanC (bacterial lantibiotic synthetase component C)-like 2LanC lantibiotic synthetase component C-like 2testis-specific adriamycin sensitivity protein
Modification date2018052320180523
UniProtAcc

Q96AW1

Q9NS86

Ensembl transtripts involved in fusion geneENST00000285279, ENST00000433959, 
ENST00000545390, ENST00000428648, 
ENST00000428097, ENST00000418904, 
ENST00000454227, ENST00000453256, 
ENST00000427700, ENST00000471168, 
ENST00000254770, ENST00000486376, 
Fusion gene scores* DoF score3 X 2 X 3=187 X 5 X 5=175
# samples 68
** MAII scorelog2(6/18*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VOPP1 [Title/Abstract] AND LANCL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLANCL2

GO:0009789

positive regulation of abscisic acid-activated signaling pathway

19667068

TgeneLANCL2

GO:0045892

negative regulation of transcription, DNA-templated

12566319


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-A6S0-01AVOPP1chr7

55639964

-LANCL2chr7

55459486

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000285279ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
5CDS-intronENST00000285279ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000433959ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000433959ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000545390ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000545390ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000428648ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000428648ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000428097ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000428097ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000418904ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000418904ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000454227ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000454227ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000453256ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000453256ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
5UTR-3CDSENST00000427700ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
5UTR-intronENST00000427700ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-3CDSENST00000471168ENST00000254770VOPP1chr7

55639964

-LANCL2chr7

55459486

+
intron-intronENST00000471168ENST00000486376VOPP1chr7

55639964

-LANCL2chr7

55459486

+

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FusionProtFeatures for VOPP1_LANCL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VOPP1

Q96AW1

LANCL2

Q9NS86

Necessary for abscisic acid (ABA) binding on the cellmembrane and activation of the ABA signaling pathway ingranulocytes. {ECO:0000269|PubMed:19667068}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVOPP1chr7:55639964chr7:55459486ENST00000285279-1587_16418173Compositional biasNote=Pro-rich
HgeneVOPP1chr7:55639964chr7:55459486ENST00000433959-1587_164-56164Compositional biasNote=Pro-rich
HgeneVOPP1chr7:55639964chr7:55459486ENST00000545390-1587_1640170Compositional biasNote=Pro-rich
HgeneVOPP1chr7:55639964chr7:55459486ENST00000285279-1523_6018173Topological domainExtracellular
HgeneVOPP1chr7:55639964chr7:55459486ENST00000285279-1582_17218173Topological domainCytoplasmic
HgeneVOPP1chr7:55639964chr7:55459486ENST00000433959-1523_60-56164Topological domainExtracellular
HgeneVOPP1chr7:55639964chr7:55459486ENST00000433959-1582_172-56164Topological domainCytoplasmic
HgeneVOPP1chr7:55639964chr7:55459486ENST00000545390-1523_600170Topological domainExtracellular
HgeneVOPP1chr7:55639964chr7:55459486ENST00000545390-1582_1720170Topological domainCytoplasmic
HgeneVOPP1chr7:55639964chr7:55459486ENST00000285279-1561_8118173TransmembraneHelical
HgeneVOPP1chr7:55639964chr7:55459486ENST00000433959-1561_81-56164TransmembraneHelical
HgeneVOPP1chr7:55639964chr7:55459486ENST00000545390-1561_810170TransmembraneHelical


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FusionGeneSequence for VOPP1_LANCL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_VOPP1_ENST00000285279_chr7_55639964_-_LANCL2_ENST00000254770_chr7_55459486_+_401aa
MRRQPAKVAALLLGLLLEIIHNFIRRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNL
NGRRVTFLCGDAGPLAVGAVIYHKLRSDCESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNA
IIESGKTLSREERKTERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHW
CHGAPGVIHMLMQAYKVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYRLTQDKKYLYRACKFAEWCLDYGAHGCRI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_VOPP1_ENST00000285279_chr7_55639964_-_LANCL2_ENST00000254770_chr7_55459486_+_1203nt
ATGAGGCGCCAGCCTGCGAAGGTGGCGGCGCTGCTGCTCGGGCTGCTCTTGGAGATCATTCATAATTTCATAAGACGGATCCAGACCAAA
ATTAAAGATCTTCTGCAGCAAATGGAAGAAGGGCTGAAGACAGCTGATCCCCATGACTGCTCTGCTTATACTGGCTGGACAGGCATAGCC
CTTTTGTACCTGCAGTTGTACCGGGTCACATGTGACCAAACCTACCTGCTCCGATCCCTGGATTACGTAAAAAGAACACTTCGGAATCTG
AATGGCCGCAGGGTCACCTTCCTCTGTGGGGATGCTGGCCCCCTGGCTGTTGGAGCTGTGATTTATCACAAACTCAGAAGTGACTGTGAG
TCCCAGGAATGTGTCACAAAACTTTTGCAGCTCCAGAGATCGGTTGTCTGCCAAGAATCAGACCTTCCTGATGAGCTGCTTTATGGACGG
GCAGGTTATCTGTATGCCTTACTGTACCTGAACACAGAGATAGGTCCAGGCACCGTGTGTGAGTCAGCTATTAAAGAGGTAGTCAATGCT
ATTATTGAATCGGGTAAGACTTTGTCAAGGGAAGAAAGAAAAACGGAGCGCTGCCCGCTGTTGTACCAGTGGCACCGGAAGCAGTACGTT
GGAGCAGCCCATGGCATGGCTGGAATTTACTATATGTTAATGCAGCCGGCAGCAAAAGTGGACCAAGAAACCTTGACAGAAATGGTGAAA
CCCAGTATTGATTATGTGCGCCACAAAAAATTCCGATCTGGGAATTACCCATCATCATTAAGCAATGAAACAGACCGGCTGGTGCACTGG
TGCCACGGCGCCCCGGGGGTCATCCACATGCTCATGCAGGCGTACAAGGTCTTTAAGGAGGAGAAGTACTTGAAAGAGGCCATGGAGTGT
AGCGATGTGATTTGGCAGCGAGGTTTGCTGCGGAAGGGCTACGGGATATGCCATGGGACTGCTGGCAACGGCTATTCCTTCCTGTCCCTT
TACCGTCTCACGCAGGATAAGAAGTACCTCTACCGAGCTTGCAAGTTTGCAGAGTGGTGTCTAGATTACGGAGCACACGGGTGCCGCATT
CCTGACAGACCCTATTCGCTCTTTGAAGGCATGGCTGGCGCTATTCACTTTCTCTCTGATGTCCTGGGACCAGAGACATCACGGTTTCCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_VOPP1_ENST00000285279_chr7_55639964_-_LANCL2_ENST00000254770_chr7_55459486_+_3826nt
GGGAGCGCGCGGCGGCCGGGGGCGGAGCGCAGCCAGGGCTGCGCGGCGCGCCCCGGCTCCCGCCCGCTCCCAGCCGGGCCCCCCAGCGGT
CGGCGGGACGGCTCCCGGCTGCAGTCTGCCCGCCCGCCCCGCGCGGGGGCCGAGTCGCGAAGCGCGCCTGCGACCCGGCGTCCGGGCGCG
CTGGAGAGGACGCGAGGAGCCATGAGGCGCCAGCCTGCGAAGGTGGCGGCGCTGCTGCTCGGGCTGCTCTTGGAGATCATTCATAATTTC
ATAAGACGGATCCAGACCAAAATTAAAGATCTTCTGCAGCAAATGGAAGAAGGGCTGAAGACAGCTGATCCCCATGACTGCTCTGCTTAT
ACTGGCTGGACAGGCATAGCCCTTTTGTACCTGCAGTTGTACCGGGTCACATGTGACCAAACCTACCTGCTCCGATCCCTGGATTACGTA
AAAAGAACACTTCGGAATCTGAATGGCCGCAGGGTCACCTTCCTCTGTGGGGATGCTGGCCCCCTGGCTGTTGGAGCTGTGATTTATCAC
AAACTCAGAAGTGACTGTGAGTCCCAGGAATGTGTCACAAAACTTTTGCAGCTCCAGAGATCGGTTGTCTGCCAAGAATCAGACCTTCCT
GATGAGCTGCTTTATGGACGGGCAGGTTATCTGTATGCCTTACTGTACCTGAACACAGAGATAGGTCCAGGCACCGTGTGTGAGTCAGCT
ATTAAAGAGGTAGTCAATGCTATTATTGAATCGGGTAAGACTTTGTCAAGGGAAGAAAGAAAAACGGAGCGCTGCCCGCTGTTGTACCAG
TGGCACCGGAAGCAGTACGTTGGAGCAGCCCATGGCATGGCTGGAATTTACTATATGTTAATGCAGCCGGCAGCAAAAGTGGACCAAGAA
ACCTTGACAGAAATGGTGAAACCCAGTATTGATTATGTGCGCCACAAAAAATTCCGATCTGGGAATTACCCATCATCATTAAGCAATGAA
ACAGACCGGCTGGTGCACTGGTGCCACGGCGCCCCGGGGGTCATCCACATGCTCATGCAGGCGTACAAGGTCTTTAAGGAGGAGAAGTAC
TTGAAAGAGGCCATGGAGTGTAGCGATGTGATTTGGCAGCGAGGTTTGCTGCGGAAGGGCTACGGGATATGCCATGGGACTGCTGGCAAC
GGCTATTCCTTCCTGTCCCTTTACCGTCTCACGCAGGATAAGAAGTACCTCTACCGAGCTTGCAAGTTTGCAGAGTGGTGTCTAGATTAC
GGAGCACACGGGTGCCGCATTCCTGACAGACCCTATTCGCTCTTTGAAGGCATGGCTGGCGCTATTCACTTTCTCTCTGATGTCCTGGGA
CCAGAGACATCACGGTTTCCAGCATTTGAACTTGACTCTTCGAAGAGGGATTAAAAGGTGCAAAAAGACAACTAAAATACCCATTTGGAC
CAAAAGCCACCAGATTGCTTAGTGCCTGACACAGAAACAACTGGGAATCCTGAAAGAGAAGCAGACACCGTCACAGGCCCCTCTGGTTAG
ACTAGCATGAGTGACCGAAGCCATCCATCAACATTTTCTAACAGCACCCTCATCAATATAAAATATGACTTCTTCACATACAGATTCTCT
GTAGTGTTTGCATGTTTCTTGGTGTTTGTTGTCTCCAGGTGTAAGCTGTTTTAAATGGAAGGCCCTTCTATTCCTGAGGGCTCAGAGCTG
ACCATGCATGAATGTATGGCAGTGTCCACTTTTCTGTATAAAATGTATAAAGTGGGGTTTCTTCCATATTGACAAATGAGGGAACAGGTG
GTGTCTATCTTGTATATCAGAAAGATTATCTAGGGTCTATCCTAGTGATAATACATTGTCAGCCTTTTCTGTGGCACCTTCCAGATGAGA
ATGAGGGAGCGACCACTCCAAGGACGGACAGGACCAGCAGTTCTGCAGGGGCGTGCTGGGGTGGTTTGGGAGTGCACAGCTGAACGCTTC
CCGTTTGGATTTTACACTCACCTTCGTGTTTTAAAGAAGCCTCAGAGTGCATTGCAGCTCTGTCAGGGCCCCATTCCCAGCAGAGGCTTC
AGGTGCTTTGTGTAGAGTCCAGGGCAGCTGGAGCTTTGTTGGGGAGACTTCTGGACCCAAAGGGAGCTTTCCCAAGAAGCCTTTGATGGC
CACACTGTAGGCAGCAGTGACTAAGCACTGGCAGTTCCAGAACATTTACCCAGGTATATGTTACTAAAACAGGCTCCACCTCAGTTTATC
AACATTATAAGTTACTGTTCTAAGAAAAGTAAATACAGTTCCAGATGGGTTATTGCAGATTAACAGAAAGACACTCAACTGGACTCATGT
CCCTGCAATTAAACTTACTTCAACCTTTTGGAAAGTTATCAAAATCTAAATTTGGAATGAATGCATTTCCTATTTTTTGTCTACTTTTGG
GTGATAAAAAGTACTAGCCCTTATTTATAGATATGAGAAACATAATGTTCTAACCAACAACATTATGGTATTTGTGTGACTTTTATTTGA
AAAAATGTGAGCAGTAATTTGGGTTAGCCTACCTTCATTAATTCTATCACATAGATTTCAGTTTTTAGAAGGGTTTCTGTCATCATGGAA
GAGGTGGTCTGGGACTAGGTACTTCTCGTCTTGTGAGCTAAGGCTTGTGTCATGAAAGACAAGAGGCCTCTCTTAACAGCCCAGTCCTTG
TCTGCAGGGGGAGGCCTGAGCATTTCCCAGCCCCAGTGTCCACACCTCTCAGAAAAGAGAAAAAAGAATGTCAGTTTAGGAGAAAAGCTT
CCTTTTTACTTGTGTGGTTATGTGTGGGGCTGGCACCCGAAATGTGTGACATTCAGCTTCTAAACGATGCCTGGAGAGTCTGTTTGCTGC
AGACACCCTTGCTCCTGAGTCATTATTTTCTTTCATGTTAGATTGATGACTTCTGTGAATAGAAATCATCCTGATCCTATTTTACCTGGC
CTCCAGGGCCTGTTGATGGGCTTTGCAGGCAGTCCAGCAGCCCACACCTGCAGGCAGGATGCTGTCGTCAATGAGCTGAGGGTAGCTGCT
TTGCTGAAGACCTCACACGATGTCCAATCTCATCCAAATAACATTGTTCCCATCCTCCCCACCCACCACATCAAAACATAACACATCACA
GCACTCAGTAGAGGTCCTGCCTCCCCATTTCTCAAGGGAAGCCAGTAGGCAACACAGCCAGCACGGTGCTCTCCAGGGCAGCCCCTCTCA
GACGAGGAGGCAGCGGGTGCAGCCAGGTGTCTGCAGAGCAGCCACAAAGGTGGCCTAGGATGCGGGTGTCTCCCCAGGTGAGTCCATCCA
CACACGTTTGAAAAACACTATTAGTCTTTCTAACACACTGAGGGAAAGATTAAAATCTGTGGAATAAAGGAGGAGATTTTATTTACAGAT
TTTTTTAAAAGCCACCTGGGTTGACACCTTCCTACTTATCCACTAGATGTCATCAGAGGTGCTGTTCCGTGGTTCTGCATTAACCCCTGC
CTCATGTCTGTAACATGTGACAGTAATTCCAGCTCGGTCCCTCCAGGCAAAGGAGAAACGGGACTTACTTCACAGGACAGAGGATTGACA
GAAGTCAGTTTAAGATAAGTGTTTGAATCAGATTTCAGTACATCTCATTCATTTCTTAGATTTGTATTCACAATTGTGTTCTCTAAAATG
TGTCTAAATTTTAAAAATATGTACATGCATAATGTCATTTTAAAATCTGAAGGAAAGAATTTGAAGTCCACAAAAAGTGTTTGAGGTTCT


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FusionGenePPI for VOPP1_LANCL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VOPP1LANCL2OTUD5, TCF3, TERF2IP, TERF2, APP, MON1B, CDK9, EGFR, APPBP2, MOV10, NXF1, FAM188A, GSTM3, MCM2, NF2, RHOU, AIRE, DOK2, KCNJ5, PVR, GMFG, FEZ1, PCGF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneLANCL2chr7:55639964chr7:55459486ENST00000254770+092_1568451inositol phospholipids


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VOPP1_LANCL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VOPP1_LANCL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVOPP1C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneVOPP1C0023893Liver Cirrhosis, Experimental1CTD_human