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Fusion gene ID: 41497 |
FusionGeneSummary for VMP1_RNFT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VMP1_RNFT1 | Fusion gene ID: 41497 | Hgene | Tgene | Gene symbol | VMP1 | RNFT1 | Gene ID | 81671 | 51136 |
| Gene name | vacuole membrane protein 1 | ring finger protein, transmembrane 1 | |
| Synonyms | EPG3|TANGO5|TMEM49 | PTD016 | |
| Cytomap | 17q23.1 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog | E3 ubiquitin-protein ligase RNFT1RING finger and transmembrane domain-containing protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96GC9 | Q5M7Z0 | |
| Ensembl transtripts involved in fusion gene | ENST00000262291, ENST00000537567, ENST00000539763, ENST00000536180, ENST00000545362, ENST00000588617, | ENST00000305783, ENST00000442346, | |
| Fusion gene scores | * DoF score | 19 X 10 X 9=1710 | 5 X 3 X 4=60 |
| # samples | 18 | 6 | |
| ** MAII score | log2(18/1710*10)=-3.24792751344359 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
| Context | PubMed: VMP1 [Title/Abstract] AND RNFT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A1FW-01A | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262291 | ENST00000305783 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| 5CDS-3UTR | ENST00000262291 | ENST00000442346 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| In-frame | ENST00000537567 | ENST00000305783 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| 5CDS-3UTR | ENST00000537567 | ENST00000442346 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| In-frame | ENST00000539763 | ENST00000305783 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| 5CDS-3UTR | ENST00000539763 | ENST00000442346 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| In-frame | ENST00000536180 | ENST00000305783 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| 5CDS-3UTR | ENST00000536180 | ENST00000442346 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| In-frame | ENST00000545362 | ENST00000305783 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| 5CDS-3UTR | ENST00000545362 | ENST00000442346 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| intron-3CDS | ENST00000588617 | ENST00000305783 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
| intron-3UTR | ENST00000588617 | ENST00000442346 | VMP1 | chr17 | 57851246 | + | RNFT1 | chr17 | 58031507 | - |
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FusionProtFeatures for VMP1_RNFT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VMP1 | RNFT1 |
| Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}. | E3 ubiquitin-protein ligase that acts in the endoplasmicreticulum (ER)-associated degradation (ERAD) pathway, whichtargets misfolded proteins that accumulate in the endoplasmicreticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-inducedapoptosis. {ECO:0000269|PubMed:27485036}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 2_43 | 238 | 407 | Topological domain | Cytoplasmic |
| Hgene | VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 65_77 | 238 | 407 | Topological domain | Extracellular |
| Hgene | VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 99_109 | 238 | 407 | Topological domain | Cytoplasmic |
| Hgene | VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 110_130 | 238 | 407 | Transmembrane | Helical |
| Hgene | VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 44_64 | 238 | 407 | Transmembrane | Helical |
| Hgene | VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 78_98 | 238 | 407 | Transmembrane | Helical |
| Tgene | >RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 368_419 | 357 | 436 | Region | Required for ubiquitin ligase activity and for protection against ER stress-induced cell death |
| Tgene | >RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 375_413 | 357 | 436 | Zinc finger | RING-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 131_250 | 238 | 407 | Topological domain | Extracellular |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 272_273 | 238 | 407 | Topological domain | Cytoplasmic |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 295_305 | 238 | 407 | Topological domain | Extracellular |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 327_363 | 238 | 407 | Topological domain | Cytoplasmic |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 385_406 | 238 | 407 | Topological domain | Extracellular |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 251_271 | 238 | 407 | Transmembrane | Helical |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 274_294 | 238 | 407 | Transmembrane | Helical |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 306_326 | 238 | 407 | Transmembrane | Helical |
| Hgene | >VMP1 | chr17:57851246 | chr17:58031507 | ENST00000262291 | + | 7 | 12 | 364_384 | 238 | 407 | Transmembrane | Helical |
| Tgene | RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 158_178 | 357 | 436 | Transmembrane | Helical |
| Tgene | RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 203_223 | 357 | 436 | Transmembrane | Helical |
| Tgene | RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 233_253 | 357 | 436 | Transmembrane | Helical |
| Tgene | RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 256_276 | 357 | 436 | Transmembrane | Helical |
| Tgene | RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 298_318 | 357 | 436 | Transmembrane | Helical |
| Tgene | RNFT1 | chr17:57851246 | chr17:58031507 | ENST00000305783 | - | 6 | 9 | 323_343 | 357 | 436 | Transmembrane | Helical |
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FusionGeneSequence for VMP1_RNFT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_VMP1_ENST00000262291_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_317aa MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLI ATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISL WSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQSYGVAASKRQCSDVDDICSICQAEFQKPILLI >In-frame_VMP1_ENST00000537567_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_183aa MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY QEFEEMLEHAESAQSYGVAASKRQCSDVDDICSICQAEFQKPILLICQHIFCEECMTLWFNREKTCPLCRTVISDHINKWKDGATSSHLQ >In-frame_VMP1_ENST00000539763_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_125aa MWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQSYGVAASKRQCSDVDDICSICQAEFQKPILLICQHIFCEECMTL >In-frame_VMP1_ENST00000536180_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_220aa MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQSYGVAASKRQCSDVDDICSICQAEFQKPILLICQHIFCE >In-frame_VMP1_ENST00000545362_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_261aa MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLI ATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAES |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_VMP1_ENST00000262291_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_951nt ATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTG AATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAA ATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATA GCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGA ATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTAT GAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTG TGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGA GCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAAGTTAT GGAGTGGCTGCCAGCAAGAGACAGTGTTCAGATGTGGATGATATTTGTTCAATATGTCAAGCTGAATTTCAGAAGCCAATTCTTCTCATT TGTCAGCATATATTTTGTGAAGAGTGCATGACCTTATGGTTTAACAGAGAGAAAACATGTCCACTCTGCAGAACTGTGATTTCAGACCAT >In-frame_VMP1_ENST00000537567_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_549nt ATGGACCTCAAAGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGAT CAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGG GGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTAT CAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAAGTTATGGAGTGGCTGCCAGCAAGAGACAGTGTTCAGATGTGGATGAT ATTTGTTCAATATGTCAAGCTGAATTTCAGAAGCCAATTCTTCTCATTTGTCAGCATATATTTTGTGAAGAGTGCATGACCTTATGGTTT AACAGAGAGAAAACATGTCCACTCTGCAGAACTGTGATTTCAGACCATATAAACAAATGGAAGGATGGAGCCACTTCATCACACCTTCAA >In-frame_VMP1_ENST00000539763_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_375nt ATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAA GAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAAGTTATGGAGTGGCTGCCAGCAAGAGACAGTGTTCAGATGTG GATGATATTTGTTCAATATGTCAAGCTGAATTTCAGAAGCCAATTCTTCTCATTTGTCAGCATATATTTTGTGAAGAGTGCATGACCTTA TGGTTTAACAGAGAGAAAACATGTCCACTCTGCAGAACTGTGATTTCAGACCATATAAACAAATGGAAGGATGGAGCCACTTCATCACAC >In-frame_VMP1_ENST00000536180_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_660nt ATGGACCTCAAATATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTT GGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTT CCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTT AGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCT GAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAAGTTATGGAGTGGCTGCCAGCAAGAGA CAGTGTTCAGATGTGGATGATATTTGTTCAATATGTCAAGCTGAATTTCAGAAGCCAATTCTTCTCATTTGTCAGCATATATTTTGTGAA GAGTGCATGACCTTATGGTTTAACAGAGAGAAAACATGTCCACTCTGCAGAACTGTGATTTCAGACCATATAAACAAATGGAAGGATGGA >In-frame_VMP1_ENST00000545362_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_783nt ATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTG AATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAA ATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATA GCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGA ATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATAT TTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCT GCACAAAGTTATGGAGTGGCTGCCAGCAAGAGACAGTGTTCAGATGTGGATGATATTTGTTCAATATGTCAAGCTGAATTTCAGAAGCCA ATTCTTCTCATTTGTCAGCATATATTTTGTGAAGAGTGCATGACCTTATGGTTTAACAGAGAGAAAACATGTCCACTCTGCAGAACTGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_VMP1_ENST00000262291_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_1998nt GACAAGTTCCGGATCAAGAATCACAAAGCGAGCAGTCATTCTTCCTCTTGCCACACCCACAGGGCCCGCACTAAGAGCCTAACTGAAATC CCGCGAGGATCAACCGAGCTCGCCGAAAGGAGGGAGGAACGTATCCCTTCTGGAGGCTGTCTCAGGGGGCAGAGGGACCGGACCGGAAGT GACGTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGC CGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAA GGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTG GAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAG CATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGA GAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTA TCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTAT TTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGG TACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATT TGAAGAGATGCTGGAACATGCAGAGTCTGCACAAAGTTATGGAGTGGCTGCCAGCAAGAGACAGTGTTCAGATGTGGATGATATTTGTTC AATATGTCAAGCTGAATTTCAGAAGCCAATTCTTCTCATTTGTCAGCATATATTTTGTGAAGAGTGCATGACCTTATGGTTTAACAGAGA GAAAACATGTCCACTCTGCAGAACTGTGATTTCAGACCATATAAACAAATGGAAGGATGGAGCCACTTCATCACACCTTCAAATATATTA AGTTGTATAAACTATCAAGGCCACAAAATACTAATGTCATTTGGTCATAATGACTACTGATAAGGCATCAGAATGGATTTTCAGGGCTAC CAGAAAAATGTTTCCAGATGGTTTTAGAATGTAGGACTTATGATCCAATTCACCAAAAGATTAAATGAAACCACCCTGTGTTTTAAAATA TATATAATGTTCAACCTAATGTATATGCAACATTTATTCTATTCTAATTATTTGACAGGTAACTGCAGTGTTAAATTGTAAATGTGTTTT CTTTATGTTACCAAAACAGCAATTTGAAATTAGAACTAGTGGTTTTAGAGAACTCAGGTATTCTTTCCTGACATTGTTTTCAGAATAAAG AATATTTTTCATAATATTTTAAGATACATACTATCTAAAAGTAGAATTTTGTTCAGCATTGACTTTTATAATTCCCATCCTAAAAATTCT TAATATTTTCATAAAATTTGTATTTTTAAATGAAAATTCTAAATGTTGTATTTTATCAGTAACATTTTCTAAGTGAAGATTAATTTACTG AGGATGATACATTATAGTATTGTATTATTCTCTGTAGTAAGATTAGTAATAAGTGAAAATAAATGATTTAAATTCATTTTGTCTCTGGAC GTCATAAATTCTTCCTGCCATCAGCTTTAATGTTCATGATCATGCTTTTTGTATAGTACCATGGAGTATCTCGAAGTAACTATTAAAATA >In-frame_VMP1_ENST00000537567_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_1613nt GTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGG GGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGA ACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAG ACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAGGTCCACATATAGCCTCAGTT ACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAA GGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCA TATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAG TCTGCACAAAGTTATGGAGTGGCTGCCAGCAAGAGACAGTGTTCAGATGTGGATGATATTTGTTCAATATGTCAAGCTGAATTTCAGAAG CCAATTCTTCTCATTTGTCAGCATATATTTTGTGAAGAGTGCATGACCTTATGGTTTAACAGAGAGAAAACATGTCCACTCTGCAGAACT GTGATTTCAGACCATATAAACAAATGGAAGGATGGAGCCACTTCATCACACCTTCAAATATATTAAGTTGTATAAACTATCAAGGCCACA AAATACTAATGTCATTTGGTCATAATGACTACTGATAAGGCATCAGAATGGATTTTCAGGGCTACCAGAAAAATGTTTCCAGATGGTTTT AGAATGTAGGACTTATGATCCAATTCACCAAAAGATTAAATGAAACCACCCTGTGTTTTAAAATATATATAATGTTCAACCTAATGTATA TGCAACATTTATTCTATTCTAATTATTTGACAGGTAACTGCAGTGTTAAATTGTAAATGTGTTTTCTTTATGTTACCAAAACAGCAATTT GAAATTAGAACTAGTGGTTTTAGAGAACTCAGGTATTCTTTCCTGACATTGTTTTCAGAATAAAGAATATTTTTCATAATATTTTAAGAT ACATACTATCTAAAAGTAGAATTTTGTTCAGCATTGACTTTTATAATTCCCATCCTAAAAATTCTTAATATTTTCATAAAATTTGTATTT TTAAATGAAAATTCTAAATGTTGTATTTTATCAGTAACATTTTCTAAGTGAAGATTAATTTACTGAGGATGATACATTATAGTATTGTAT TATTCTCTGTAGTAAGATTAGTAATAAGTGAAAATAAATGATTTAAATTCATTTTGTCTCTGGACGTCATAAATTCTTCCTGCCATCAGC >In-frame_VMP1_ENST00000539763_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_1677nt GAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGG TCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAAC ATCATAATGGAAATTTCACAGATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTA TGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTC TGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTC AGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCAT CTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCT CTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAAGTTATGGAGTGGCTGC CAGCAAGAGACAGTGTTCAGATGTGGATGATATTTGTTCAATATGTCAAGCTGAATTTCAGAAGCCAATTCTTCTCATTTGTCAGCATAT ATTTTGTGAAGAGTGCATGACCTTATGGTTTAACAGAGAGAAAACATGTCCACTCTGCAGAACTGTGATTTCAGACCATATAAACAAATG GAAGGATGGAGCCACTTCATCACACCTTCAAATATATTAAGTTGTATAAACTATCAAGGCCACAAAATACTAATGTCATTTGGTCATAAT GACTACTGATAAGGCATCAGAATGGATTTTCAGGGCTACCAGAAAAATGTTTCCAGATGGTTTTAGAATGTAGGACTTATGATCCAATTC ACCAAAAGATTAAATGAAACCACCCTGTGTTTTAAAATATATATAATGTTCAACCTAATGTATATGCAACATTTATTCTATTCTAATTAT TTGACAGGTAACTGCAGTGTTAAATTGTAAATGTGTTTTCTTTATGTTACCAAAACAGCAATTTGAAATTAGAACTAGTGGTTTTAGAGA ACTCAGGTATTCTTTCCTGACATTGTTTTCAGAATAAAGAATATTTTTCATAATATTTTAAGATACATACTATCTAAAAGTAGAATTTTG TTCAGCATTGACTTTTATAATTCCCATCCTAAAAATTCTTAATATTTTCATAAAATTTGTATTTTTAAATGAAAATTCTAAATGTTGTAT TTTATCAGTAACATTTTCTAAGTGAAGATTAATTTACTGAGGATGATACATTATAGTATTGTATTATTCTCTGTAGTAAGATTAGTAATA AGTGAAAATAAATGATTTAAATTCATTTTGTCTCTGGACGTCATAAATTCTTCCTGCCATCAGCTTTAATGTTCATGATCATGCTTTTTG >In-frame_VMP1_ENST00000536180_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_1707nt GTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTC AAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATT TCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCT TGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAATATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGC CTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTC AGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCAC TGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCC TCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGC AGAGTCTGCACAAAGTTATGGAGTGGCTGCCAGCAAGAGACAGTGTTCAGATGTGGATGATATTTGTTCAATATGTCAAGCTGAATTTCA GAAGCCAATTCTTCTCATTTGTCAGCATATATTTTGTGAAGAGTGCATGACCTTATGGTTTAACAGAGAGAAAACATGTCCACTCTGCAG AACTGTGATTTCAGACCATATAAACAAATGGAAGGATGGAGCCACTTCATCACACCTTCAAATATATTAAGTTGTATAAACTATCAAGGC CACAAAATACTAATGTCATTTGGTCATAATGACTACTGATAAGGCATCAGAATGGATTTTCAGGGCTACCAGAAAAATGTTTCCAGATGG TTTTAGAATGTAGGACTTATGATCCAATTCACCAAAAGATTAAATGAAACCACCCTGTGTTTTAAAATATATATAATGTTCAACCTAATG TATATGCAACATTTATTCTATTCTAATTATTTGACAGGTAACTGCAGTGTTAAATTGTAAATGTGTTTTCTTTATGTTACCAAAACAGCA ATTTGAAATTAGAACTAGTGGTTTTAGAGAACTCAGGTATTCTTTCCTGACATTGTTTTCAGAATAAAGAATATTTTTCATAATATTTTA AGATACATACTATCTAAAAGTAGAATTTTGTTCAGCATTGACTTTTATAATTCCCATCCTAAAAATTCTTAATATTTTCATAAAATTTGT ATTTTTAAATGAAAATTCTAAATGTTGTATTTTATCAGTAACATTTTCTAAGTGAAGATTAATTTACTGAGGATGATACATTATAGTATT GTATTATTCTCTGTAGTAAGATTAGTAATAAGTGAAAATAAATGATTTAAATTCATTTTGTCTCTGGACGTCATAAATTCTTCCTGCCAT >In-frame_VMP1_ENST00000545362_chr17_57851246_+_RNFT1_ENST00000305783_chr17_58031507_-_1573nt GATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTG TAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGA ATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTAT GGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATG TGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACA CCTTTCTGCTTTATCTGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAAC CAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAAGTTATGGAGTGGCTGCCAGCAAGAGACAGT GTTCAGATGTGGATGATATTTGTTCAATATGTCAAGCTGAATTTCAGAAGCCAATTCTTCTCATTTGTCAGCATATATTTTGTGAAGAGT GCATGACCTTATGGTTTAACAGAGAGAAAACATGTCCACTCTGCAGAACTGTGATTTCAGACCATATAAACAAATGGAAGGATGGAGCCA CTTCATCACACCTTCAAATATATTAAGTTGTATAAACTATCAAGGCCACAAAATACTAATGTCATTTGGTCATAATGACTACTGATAAGG CATCAGAATGGATTTTCAGGGCTACCAGAAAAATGTTTCCAGATGGTTTTAGAATGTAGGACTTATGATCCAATTCACCAAAAGATTAAA TGAAACCACCCTGTGTTTTAAAATATATATAATGTTCAACCTAATGTATATGCAACATTTATTCTATTCTAATTATTTGACAGGTAACTG CAGTGTTAAATTGTAAATGTGTTTTCTTTATGTTACCAAAACAGCAATTTGAAATTAGAACTAGTGGTTTTAGAGAACTCAGGTATTCTT TCCTGACATTGTTTTCAGAATAAAGAATATTTTTCATAATATTTTAAGATACATACTATCTAAAAGTAGAATTTTGTTCAGCATTGACTT TTATAATTCCCATCCTAAAAATTCTTAATATTTTCATAAAATTTGTATTTTTAAATGAAAATTCTAAATGTTGTATTTTATCAGTAACAT TTTCTAAGTGAAGATTAATTTACTGAGGATGATACATTATAGTATTGTATTATTCTCTGTAGTAAGATTAGTAATAAGTGAAAATAAATG ATTTAAATTCATTTTGTCTCTGGACGTCATAAATTCTTCCTGCCATCAGCTTTAATGTTCATGATCATGCTTTTTGTATAGTACCATGGA |
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FusionGenePPI for VMP1_RNFT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| VMP1 | HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA | RNFT1 | UBE2U, NXF1, KRAS, IL17RB, REEP5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VMP1_RNFT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VMP1_RNFT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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