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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41487

FusionGeneSummary for VMP1_C17orf64

check button Fusion gene summary
Fusion gene informationFusion gene name: VMP1_C17orf64
Fusion gene ID: 41487
HgeneTgene
Gene symbol

VMP1

C17orf64

Gene ID

81671

124773

Gene namevacuole membrane protein 1chromosome 17 open reading frame 64
SynonymsEPG3|TANGO5|TMEM49-
Cytomap

17q23.1

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homologuncharacterized protein C17orf64
Modification date2018052320180519
UniProtAcc

Q96GC9

Q86WR6

Ensembl transtripts involved in fusion geneENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
ENST00000269127, 
Fusion gene scores* DoF score19 X 10 X 9=17106 X 3 X 3=54
# samples 186
** MAII scorelog2(18/1710*10)=-3.24792751344359
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/54*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VMP1 [Title/Abstract] AND C17orf64 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24R-01AVMP1chr17

57851246

+C17orf64chr17

58503144

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262291ENST00000269127VMP1chr17

57851246

+C17orf64chr17

58503144

+
In-frameENST00000537567ENST00000269127VMP1chr17

57851246

+C17orf64chr17

58503144

+
In-frameENST00000539763ENST00000269127VMP1chr17

57851246

+C17orf64chr17

58503144

+
In-frameENST00000536180ENST00000269127VMP1chr17

57851246

+C17orf64chr17

58503144

+
In-frameENST00000545362ENST00000269127VMP1chr17

57851246

+C17orf64chr17

58503144

+
intron-3CDSENST00000588617ENST00000269127VMP1chr17

57851246

+C17orf64chr17

58503144

+

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FusionProtFeatures for VMP1_C17orf64


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VMP1

Q96GC9

C17orf64

Q86WR6

Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+7122_43238407Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+71265_77238407Topological domainExtracellular
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+71299_109238407Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712110_130238407TransmembraneHelical
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+71244_64238407TransmembraneHelical
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+71278_98238407TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712131_250238407Topological domainExtracellular
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712272_273238407Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712295_305238407Topological domainExtracellular
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712327_363238407Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712385_406238407Topological domainExtracellular
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712251_271238407TransmembraneHelical
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712274_294238407TransmembraneHelical
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712306_326238407TransmembraneHelical
HgeneVMP1chr17:57851246chr17:58503144ENST00000262291+712364_384238407TransmembraneHelical


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FusionGeneSequence for VMP1_C17orf64


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_VMP1_ENST00000262291_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_458aa
MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQTFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLI
ATTTVEGVHQQTVQRIEKQFLLTAYWIGLGILSSVGLGTGLHTFLLTLGPHIASVTLAATECNSVNFPEPPTPDQIICPDEEGTEGTISL
WSIISKVRIEACMWGIGTAIGELPPTFMARAARLSGAEPDDEETQEFEEMLEHAESAQVTNVSCLETSSSASPARDSLMRHAKGLDQDTF
KTCKEYLRPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQAWEIKHWRKMLWRFISLFSELEAKQLRRLYKYTKSSQP
AKFLVTFCASDAPERSLLADREDSLPKLCHAWGLHSNISGMKERLSNMQTPGQGSPLPGQPRSQDHVKKDSLRELSQKPKLKRKRIKEAP

>In-frame_VMP1_ENST00000537567_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_324aa
MDLKGPHIASVTLAATECNSVNFPEPPTPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPTFMARAARLSGAEPDDEET
QEFEEMLEHAESAQVTNVSCLETSSSASPARDSLMRHAKGLDQDTFKTCKEYLRPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVLGDHIN
TFLQHYCQAWEIKHWRKMLWRFISLFSELEAKQLRRLYKYTKSSQPAKFLVTFCASDAPERSLLADREDSLPKLCHAWGLHSNISGMKER

>In-frame_VMP1_ENST00000539763_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_266aa
MWGIGTAIGELPPTFMARAARLSGAEPDDEETQEFEEMLEHAESAQVTNVSCLETSSSASPARDSLMRHAKGLDQDTFKTCKEYLRPLKK
FLRKLHLPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQAWEIKHWRKMLWRFISLFSELEAKQLRRLYKYTKSSQPAKFLVTFCASDA

>In-frame_VMP1_ENST00000536180_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_361aa
MDLKTVQRIEKQFLLTAYWIGLGILSSVGLGTGLHTFLLTLGPHIASVTLAATECNSVNFPEPPTPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPTFMARAARLSGAEPDDEETQEFEEMLEHAESAQVTNVSCLETSSSASPARDSLMRHAKGLDQDTFKTCKEYL
RPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQAWEIKHWRKMLWRFISLFSELEAKQLRRLYKYTKSSQPAKFLVTF
CASDAPERSLLADREDSLPKLCHAWGLHSNISGMKERLSNMQTPGQGSPLPGQPRSQDHVKKDSLRELSQKPKLKRKRIKEAPETPETEP

>In-frame_VMP1_ENST00000545362_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_402aa
MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQTFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLI
ATTTVEGVHQQTVQRIEKQFLLTAYWIGLGILSSVGLGTGLHTFLLTLGIGTAIGELPPTFMARAARLSGAEPDDEETQEFEEMLEHAES
AQVTNVSCLETSSSASPARDSLMRHAKGLDQDTFKTCKEYLRPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQAWEI
KHWRKMLWRFISLFSELEAKQLRRLYKYTKSSQPAKFLVTFCASDAPERSLLADREDSLPKLCHAWGLHSNISGMKERLSNMQTPGQGSP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_VMP1_ENST00000262291_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1374nt
ATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTG
AATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAA
ATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATA
GCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGA
ATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTAT
GAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTG
TGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGA
GCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGTGACA
AATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGCCCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTC
AAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAGTTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAG
TACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCACATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGA
AAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAGCTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCG
GCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCGCCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCAT
GCATGGGGGCTGCACAGCAACATCAGCGGCATGAAGGAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAG
CCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTAAGGGAGCTTTCTCAAAAACCAAAACTCAAGAGGAAGAGGATAAAGGAAGCCCCA

>In-frame_VMP1_ENST00000537567_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_972nt
ATGGACCTCAAAGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGAT
CAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGG
GGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTAT
CAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGCCCTGCT
AGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAGTTCCTG
CGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCACATCAAC
ACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAGCTGGAA
GCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCGCCGGAG
AGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAGGAGCGG
CTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTAAGGGAG

>In-frame_VMP1_ENST00000539763_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_798nt
ATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAA
GAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGC
CCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAG
TTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCAC
ATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAG
CTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCG
CCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAG
GAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTA

>In-frame_VMP1_ENST00000536180_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1083nt
ATGGACCTCAAATATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTT
GGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTT
CCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTT
AGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCT
GAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGTGACAAATGTGTCATGCCTGGAGACA
AGCTCCAGCGCCAGCCCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTA
AGACCGCTGAAGAAGTTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTG
GTCCTAGGGGACCACATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATC
TCCCTCTTCTCGGAGCTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTC
TGCGCCTCGGATGCGCCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAAC
ATCAGCGGCATGAAGGAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTC
AAGAAAGATTCTTTAAGGGAGCTTTCTCAAAAACCAAAACTCAAGAGGAAGAGGATAAAGGAAGCCCCAGAAACTCCAGAGACTGAACCG

>In-frame_VMP1_ENST00000545362_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1206nt
ATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTG
AATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAA
ATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATA
GCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGA
ATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATAT
TTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCT
GCACAAGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGCCCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGAT
CAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAGTTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAG
AAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCACATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATC
AAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAGCTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAG
AGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCGCCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCC
AAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAGGAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCC
CTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTAAGGGAGCTTTCTCAAAAACCAAAACTCAAGAGGAAGAGGATA


* Fusion transcript sequences (Full-length transcript).
>In-frame_VMP1_ENST00000262291_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1839nt
GACAAGTTCCGGATCAAGAATCACAAAGCGAGCAGTCATTCTTCCTCTTGCCACACCCACAGGGCCCGCACTAAGAGCCTAACTGAAATC
CCGCGAGGATCAACCGAGCTCGCCGAAAGGAGGGAGGAACGTATCCCTTCTGGAGGCTGTCTCAGGGGGCAGAGGGACCGGACCGGAAGT
GACGTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGC
CGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAA
GGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTG
GAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAG
CATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGA
GAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTA
TCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTAT
TTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGG
TACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATT
TGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGCCCTGCTAGAGACTC
GCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAGTTCCTGCGAAAGTT
GCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCACATCAACACCTTTCT
GCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAGCTGGAAGCAAAGCA
GCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCGCCGGAGAGGTCCTT
GCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAGGAGCGGCTGTCCAA
CATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTAAGGGAGCTTTCTCA
AAAACCAAAACTCAAGAGGAAGAGGATAAAGGAAGCCCCAGAAACTCCAGAGACTGAACCGTAAGAAGACCAACTGGGACAAAGGGCCCG
CTTGTCCTGGCTCTCAGAGCACGGGGAATGGAGACCAAAAAGGGAAAAGAATTGTCCTTATCAAAAAGATTCTCAGGTCTTAATTAGGAA

>In-frame_VMP1_ENST00000537567_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1454nt
GTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGG
GGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGA
ACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAG
ACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAGGTCCACATATAGCCTCAGTT
ACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAA
GGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCA
TATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAG
TCTGCACAAGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGCCCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTG
GATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAGTTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAG
AAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCACATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAA
ATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAGCTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACC
AAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCGCCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTG
CCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAGGAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGC
CCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTAAGGGAGCTTTCTCAAAAACCAAAACTCAAGAGGAAGAGG
ATAAAGGAAGCCCCAGAAACTCCAGAGACTGAACCGTAAGAAGACCAACTGGGACAAAGGGCCCGCTTGTCCTGGCTCTCAGAGCACGGG
GAATGGAGACCAAAAAGGGAAAAGAATTGTCCTTATCAAAAAGATTCTCAGGTCTTAATTAGGAATAAATGAGGTGGGAAATAAACATTC

>In-frame_VMP1_ENST00000539763_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1518nt
GAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGG
TCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAAC
ATCATAATGGAAATTTCACAGATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTA
TGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTC
TGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTC
AGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCAT
CTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCT
CTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGTGACAAATGTGTCATG
CCTGGAGACAAGCTCCAGCGCCAGCCCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAA
AGAATACCTAAGACCGCTGAAGAAGTTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCA
GAGCCTTGTGGTCCTAGGGGACCACATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTG
GCGGTTCATCTCCCTCTTCTCGGAGCTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCT
GGTGACATTCTGCGCCTCGGATGCGCCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCT
GCACAGCAACATCAGCGGCATGAAGGAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCA
GGACCATGTCAAGAAAGATTCTTTAAGGGAGCTTTCTCAAAAACCAAAACTCAAGAGGAAGAGGATAAAGGAAGCCCCAGAAACTCCAGA
GACTGAACCGTAAGAAGACCAACTGGGACAAAGGGCCCGCTTGTCCTGGCTCTCAGAGCACGGGGAATGGAGACCAAAAAGGGAAAAGAA

>In-frame_VMP1_ENST00000536180_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1548nt
GTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTC
AAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATT
TCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCT
TGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAATATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGC
CTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTC
AGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCAC
TGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCC
TCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGC
AGAGTCTGCACAAGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGCCCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGG
CCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAGTTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCC
CCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCACATCAACACCTTTCTGCAGCATTACTGCCAAGCCTG
GGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAGCTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTA
CACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCGCCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAG
TCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAGGAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGG
GAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTAAGGGAGCTTTCTCAAAAACCAAAACTCAAGAGGAA
GAGGATAAAGGAAGCCCCAGAAACTCCAGAGACTGAACCGTAAGAAGACCAACTGGGACAAAGGGCCCGCTTGTCCTGGCTCTCAGAGCA
CGGGGAATGGAGACCAAAAAGGGAAAAGAATTGTCCTTATCAAAAAGATTCTCAGGTCTTAATTAGGAATAAATGAGGTGGGAAATAAAC

>In-frame_VMP1_ENST00000545362_chr17_57851246_+_C17orf64_ENST00000269127_chr17_58503144_+_1414nt
GATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTG
TAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGA
ATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTAT
GGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATG
TGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACA
CCTTTCTGCTTTATCTGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAAC
CAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGTGACAAATGTGTCATGCCTGGAGACAAGCT
CCAGCGCCAGCCCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGAC
CGCTGAAGAAGTTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCC
TAGGGGACCACATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCC
TCTTCTCGGAGCTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCG
CCTCGGATGCGCCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCA
GCGGCATGAAGGAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGA
AAGATTCTTTAAGGGAGCTTTCTCAAAAACCAAAACTCAAGAGGAAGAGGATAAAGGAAGCCCCAGAAACTCCAGAGACTGAACCGTAAG
AAGACCAACTGGGACAAAGGGCCCGCTTGTCCTGGCTCTCAGAGCACGGGGAATGGAGACCAAAAAGGGAAAAGAATTGTCCTTATCAAA


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FusionGenePPI for VMP1_C17orf64


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VMP1HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNAC17orf64DUSP12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VMP1_C17orf64


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VMP1_C17orf64


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource