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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41483

FusionGeneSummary for VMA21_GLIS1

check button Fusion gene summary
Fusion gene informationFusion gene name: VMA21_GLIS1
Fusion gene ID: 41483
HgeneTgene
Gene symbol

VMA21

GLIS1

Gene ID

203547

148979

Gene nameVMA21, vacuolar ATPase assembly factorGLIS family zinc finger 1
SynonymsMEAX|XMEA-
Cytomap

Xq28

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionvacuolar ATPase assembly integral membrane protein VMA21VMA21 vacuolar H+-ATPase homologmyopathy with excessive autophagy proteinzinc finger protein GLIS1GLI-similar 1
Modification date2018051920180403
UniProtAcc

Q3ZAQ7

Q8NBF1

Ensembl transtripts involved in fusion geneENST00000477649, ENST00000370361, 
ENST00000330374, 
ENST00000312233, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 5 X 5=175
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VMA21 [Title/Abstract] AND GLIS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF515448VMA21chrX

150566070

+GLIS1chr1

54118854

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000477649ENST00000312233VMA21chrX

150566070

+GLIS1chr1

54118854

-
intron-intronENST00000370361ENST00000312233VMA21chrX

150566070

+GLIS1chr1

54118854

-
intron-intronENST00000330374ENST00000312233VMA21chrX

150566070

+GLIS1chr1

54118854

-

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FusionProtFeatures for VMA21_GLIS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VMA21

Q3ZAQ7

GLIS1

Q8NBF1

Required for the assembly of the V0 complex of thevacuolar ATPase (V-ATPase) in the endoplasmic reticulum.{ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691}. Acts as both a repressor and activator of transcription.Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).{ECO:0000250|UniProtKB:Q8K1M4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VMA21_GLIS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VMA21_GLIS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VMA21_GLIS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VMA21_GLIS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource