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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41459

FusionGeneSummary for VIM-AS1_DOCK11

check button Fusion gene summary
Fusion gene informationFusion gene name: VIM-AS1_DOCK11
Fusion gene ID: 41459
HgeneTgene
Gene symbol

VIM-AS1

DOCK11

Gene ID

100507347

139818

Gene nameVIM antisense RNA 1dedicator of cytokinesis 11
Synonyms-ACG|ZIZ2|bB128O4.1
Cytomap

10p13

Xq24

Type of genencRNAprotein-coding
Description-dedicator of cytokinesis protein 11Activated Cdc42-associated guanine nucleotide exchange factor, ACGbB128O4.1.1 (novel protein)zizimin-2zizimin2
Modification date2018042120180519
UniProtAcc

Q5JSL3

Ensembl transtripts involved in fusion geneENST00000437232, ENST00000605833, 
ENST00000276204, ENST00000276202, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 6 X 6=216
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VIM-AS1 [Title/Abstract] AND DOCK11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ365892VIM-AS1chr10

17268299

-DOCK11chrX

117752613

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000437232ENST00000276204VIM-AS1chr10

17268299

-DOCK11chrX

117752613

+
intron-3CDSENST00000437232ENST00000276202VIM-AS1chr10

17268299

-DOCK11chrX

117752613

+
intron-3CDSENST00000605833ENST00000276204VIM-AS1chr10

17268299

-DOCK11chrX

117752613

+
intron-3CDSENST00000605833ENST00000276202VIM-AS1chr10

17268299

-DOCK11chrX

117752613

+

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FusionProtFeatures for VIM-AS1_DOCK11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VIM-AS1

DOCK11

Q5JSL3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Guanine nucleotide-exchange factor (GEF) that activatesCDC42 by exchanging bound GDP for free GTP. Required for marginalzone (MZ) B-cell development, is associated with early bone marrowB-cell development, MZ B-cell formation, MZ B-cell number andmarginal metallophilic macrophages morphology. Facilitatesfilopodia formation through the activation of CDC42.{ECO:0000250|UniProtKB:A2AF47}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VIM-AS1_DOCK11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VIM-AS1_DOCK11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VIM-AS1_DOCK11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VIM-AS1_DOCK11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource