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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41441

FusionGeneSummary for VGLL4_FOXP1

check button Fusion gene summary
Fusion gene informationFusion gene name: VGLL4_FOXP1
Fusion gene ID: 41441
HgeneTgene
Gene symbol

VGLL4

FOXP1

Gene ID

9686

27086

Gene namevestigial like family member 4forkhead box P1
SynonymsVGL-412CC4|HSPC215|MFH|QRF1|hFKH1B
Cytomap

3p25.3-p25.2

3p13

Type of geneprotein-codingprotein-coding
Descriptiontranscription cofactor vestigial-like protein 4Vestigial-like 4vestigial like 4forkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead
Modification date2018051920180522
UniProtAcc

Q14135

Q9H334

Ensembl transtripts involved in fusion geneENST00000273038, ENST00000430365, 
ENST00000404339, ENST00000480288, 
ENST00000413604, ENST00000451674, 
ENST00000424529, 
ENST00000318789, 
ENST00000475937, ENST00000493089, 
ENST00000484350, ENST00000318779, 
ENST00000491238, ENST00000498215, 
ENST00000468577, ENST00000472382, 
Fusion gene scores* DoF score13 X 10 X 6=78037 X 16 X 17=10064
# samples 1740
** MAII scorelog2(17/780*10)=-2.19793937761191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(40/10064*10)=-4.65306001710456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VGLL4 [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

TgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

TgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

TgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

TgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

TgeneFOXP1

GO:0036035

osteoclast development

18799727

TgeneFOXP1

GO:0042116

macrophage activation

18799727

TgeneFOXP1

GO:0042117

monocyte activation

18799727

TgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

TgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

TgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

TgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

TgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

TgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

TgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

TgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5740-01AVGLL4chr3

11597544

-FOXP1chr3

71007472

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000273038ENST00000318789VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000273038ENST00000475937VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-intronENST00000273038ENST00000493089VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-intronENST00000273038ENST00000484350VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-intronENST00000273038ENST00000318779VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-intronENST00000273038ENST00000491238VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-intronENST00000273038ENST00000498215VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-intronENST00000273038ENST00000468577VGLL4chr3

11597544

-FOXP1chr3

71007472

-
5CDS-intronENST00000273038ENST00000472382VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000430365ENST00000318789VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000430365ENST00000475937VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000430365ENST00000493089VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000430365ENST00000484350VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000430365ENST00000318779VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000430365ENST00000491238VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000430365ENST00000498215VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000430365ENST00000468577VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000430365ENST00000472382VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000404339ENST00000318789VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000404339ENST00000475937VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000404339ENST00000493089VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000404339ENST00000484350VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000404339ENST00000318779VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000404339ENST00000491238VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000404339ENST00000498215VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000404339ENST00000468577VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000404339ENST00000472382VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000480288ENST00000318789VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000480288ENST00000475937VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000480288ENST00000493089VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000480288ENST00000484350VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000480288ENST00000318779VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000480288ENST00000491238VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000480288ENST00000498215VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000480288ENST00000468577VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000480288ENST00000472382VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000413604ENST00000318789VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000413604ENST00000475937VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000413604ENST00000493089VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000413604ENST00000484350VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000413604ENST00000318779VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000413604ENST00000491238VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000413604ENST00000498215VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000413604ENST00000468577VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000413604ENST00000472382VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000451674ENST00000318789VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000451674ENST00000475937VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000451674ENST00000493089VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000451674ENST00000484350VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000451674ENST00000318779VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000451674ENST00000491238VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000451674ENST00000498215VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000451674ENST00000468577VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000451674ENST00000472382VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000424529ENST00000318789VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-3UTRENST00000424529ENST00000475937VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000424529ENST00000493089VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000424529ENST00000484350VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000424529ENST00000318779VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000424529ENST00000491238VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000424529ENST00000498215VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000424529ENST00000468577VGLL4chr3

11597544

-FOXP1chr3

71007472

-
intron-intronENST00000424529ENST00000472382VGLL4chr3

11597544

-FOXP1chr3

71007472

-

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FusionProtFeatures for VGLL4_FOXP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VGLL4

Q14135

FOXP1

Q9H334

May act as a specific coactivator for the mammalianTEFs. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VGLL4_FOXP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VGLL4_FOXP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VGLL4TEAD1, MEF2A, ELAVL1, TERF2IP, IRF2BP2, CDK6, IRF2BP1, IRF2BPL, TEAD4, TEAD3, USP11, TRIM25FOXP1CTBP1, FOXP1, FOXP2, FOXP4, GATAD2B, MTA1, NCOR2, ELAVL1, MYC, IL3RA, CCDC183, UNK, RCC1, HOXD13, QSER1, SATB1, SATB2, CTBP2, MYH10, LIG3, C10orf2, CUX1, VRK3, XRCC1, CHD1L, RPA2, BLM, MRE11A, MYL12B, TBP, TP53, TTF2, ZBTB10, MYL9, RPA3, TFCP2, TOP2A, UBP1, FOXP3, AURKA, SNRNP70


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VGLL4_FOXP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VGLL4_FOXP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
TgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
TgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
TgeneFOXP1C0042900Vitiligo1CTD_human
TgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
TgeneFOXP1C3495559Juvenile arthritis1CTD_human
TgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT