FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41433

FusionGeneSummary for VEZT_FGD6

check button Fusion gene summary
Fusion gene informationFusion gene name: VEZT_FGD6
Fusion gene ID: 41433
HgeneTgene
Gene symbol

VEZT

FGD6

Gene ID

55591

55785

Gene namevezatin, adherens junctions transmembrane proteinFYVE, RhoGEF and PH domain containing 6
SynonymsVEZATINZFYVE24
Cytomap

12q22

12q22

Type of geneprotein-codingprotein-coding
DescriptionvezatinFYVE, RhoGEF and PH domain-containing protein 6zinc finger FYVE domain-containing protein 24
Modification date2018051920180519
UniProtAcc

Q9HBM0

Q6ZV73

Ensembl transtripts involved in fusion geneENST00000436874, ENST00000261219, 
ENST00000356859, 
ENST00000343958, 
ENST00000546711, ENST00000549499, 
ENST00000550368, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 2=32
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VEZT [Title/Abstract] AND FGD6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTGCTTCGA-WZ-A7V3-01AVEZTchr12

95611662

+FGD6chr12

95502337

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000436874ENST00000343958VEZTchr12

95611662

+FGD6chr12

95502337

-
Frame-shiftENST00000436874ENST00000546711VEZTchr12

95611662

+FGD6chr12

95502337

-
Frame-shiftENST00000436874ENST00000549499VEZTchr12

95611662

+FGD6chr12

95502337

-
5CDS-intronENST00000436874ENST00000550368VEZTchr12

95611662

+FGD6chr12

95502337

-
5UTR-3CDSENST00000261219ENST00000343958VEZTchr12

95611662

+FGD6chr12

95502337

-
5UTR-3CDSENST00000261219ENST00000546711VEZTchr12

95611662

+FGD6chr12

95502337

-
5UTR-3CDSENST00000261219ENST00000549499VEZTchr12

95611662

+FGD6chr12

95502337

-
5UTR-intronENST00000261219ENST00000550368VEZTchr12

95611662

+FGD6chr12

95502337

-
intron-3CDSENST00000356859ENST00000343958VEZTchr12

95611662

+FGD6chr12

95502337

-
intron-3CDSENST00000356859ENST00000546711VEZTchr12

95611662

+FGD6chr12

95502337

-
intron-3CDSENST00000356859ENST00000549499VEZTchr12

95611662

+FGD6chr12

95502337

-
intron-intronENST00000356859ENST00000550368VEZTchr12

95611662

+FGD6chr12

95502337

-

Top

FusionProtFeatures for VEZT_FGD6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VEZT

Q9HBM0

FGD6

Q6ZV73

Plays a pivotal role in the establishment of adherensjunctions and their maintenance in adult life. In case of Listeriainfection, promotes bacterial internalization by participating inmyosin VIIa recruitment to the entry site.{ECO:0000269|PubMed:15090598}. May activate CDC42, a member of the Ras-like family ofRho- and Rac proteins, by exchanging bound GDP for free GTP. Mayplay a role in regulating the actin cytoskeleton and cell shape(By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for VEZT_FGD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for VEZT_FGD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VEZTMYO7A, CTNNA1, CTNNB1, CDH1, ELAVL1, PLEKHO2, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, CTDNEP1, TPTE, VIPR2, C3AR1, TMED6, GPR21, FZD10, DLK2, CHRM4, IPPKFGD6GRB2, NPM1, DBNL, GBA, PDGFRB, CTR9, PLK2, CCDC102B, KCTD3, KIF13B, CGN, ZBTB21, KSR1, CBY1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for VEZT_FGD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for VEZT_FGD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFGD6C0345967Malignant mesothelioma1CTD_human
TgeneFGD6C2237660exudative macular degeneration1CTD_human