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Fusion gene ID: 41424 |
FusionGeneSummary for VEGFA_TRBV20-1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VEGFA_TRBV20-1 | Fusion gene ID: 41424 | Hgene | Tgene | Gene symbol | VEGFA | TRBV20-1 | Gene ID | 7422 | 28567 |
| Gene name | vascular endothelial growth factor A | T cell receptor beta variable 20-1 | |
| Synonyms | MVCD1|VEGF|VPF | TCRBV20S1|TCRBV2S1|TRBV201 | |
| Cytomap | 6p21.1 | 7q34 | |
| Type of gene | protein-coding | other | |
| Description | vascular endothelial growth factor Avascular endothelial growth factor A121vascular endothelial growth factor A165vascular permeability factor | V_segment translation product | |
| Modification date | 20180527 | 20180529 | |
| UniProtAcc | P15692 | ||
| Ensembl transtripts involved in fusion gene | ENST00000372067, ENST00000417285, ENST00000324450, ENST00000413642, ENST00000372055, ENST00000482630, ENST00000425836, ENST00000372064, ENST00000372077, ENST00000520948, ENST00000523873, ENST00000523950, ENST00000518689, ENST00000523125, ENST00000457104, ENST00000518824, ENST00000230480, | ENST00000390394, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 8 X 10 X 1=80 |
| # samples | 7 | 10 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/80*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VEGFA [Title/Abstract] AND TRBV20-1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VEGFA | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18093989 |
| Hgene | VEGFA | GO:0001525 | angiogenesis | 11427521|21771332 |
| Hgene | VEGFA | GO:0001666 | response to hypoxia | 16490744 |
| Hgene | VEGFA | GO:0001934 | positive regulation of protein phosphorylation | 18386220|19033661 |
| Hgene | VEGFA | GO:0001938 | positive regulation of endothelial cell proliferation | 9202027|10022831|12714610|16489009|18386220|18577655|20497126 |
| Hgene | VEGFA | GO:0002042 | cell migration involved in sprouting angiogenesis | 18059339|20660291 |
| Hgene | VEGFA | GO:0002092 | positive regulation of receptor internalization | 20660291 |
| Hgene | VEGFA | GO:0008284 | positive regulation of cell proliferation | 7929439 |
| Hgene | VEGFA | GO:0008360 | regulation of cell shape | 7929439|10527820 |
| Hgene | VEGFA | GO:0010595 | positive regulation of endothelial cell migration | 10022831|19033661 |
| Hgene | VEGFA | GO:0010628 | positive regulation of gene expression | 18386220 |
| Hgene | VEGFA | GO:0010629 | negative regulation of gene expression | 28977001 |
| Hgene | VEGFA | GO:0030224 | monocyte differentiation | 21149635 |
| Hgene | VEGFA | GO:0030225 | macrophage differentiation | 21149635 |
| Hgene | VEGFA | GO:0030335 | positive regulation of cell migration | 7929439|17470632 |
| Hgene | VEGFA | GO:0030823 | regulation of cGMP metabolic process | 16150726 |
| Hgene | VEGFA | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 1312256|7929439 |
| Hgene | VEGFA | GO:0031334 | positive regulation of protein complex assembly | 16489009|19033661 |
| Hgene | VEGFA | GO:0031954 | positive regulation of protein autophosphorylation | 20497126 |
| Hgene | VEGFA | GO:0032147 | activation of protein kinase activity | 18059339|20497126 |
| Hgene | VEGFA | GO:0032793 | positive regulation of CREB transcription factor activity | 20497126 |
| Hgene | VEGFA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 18440775|20497126 |
| Hgene | VEGFA | GO:0035148 | tube formation | 19033661 |
| Hgene | VEGFA | GO:0035767 | endothelial cell chemotaxis | 18440775 |
| Hgene | VEGFA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 18440775|20497126 |
| Hgene | VEGFA | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway | 18440775|20497126|21245381 |
| Hgene | VEGFA | GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | 17470632 |
| Hgene | VEGFA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 19390056 |
| Hgene | VEGFA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18386220 |
| Hgene | VEGFA | GO:0043406 | positive regulation of MAP kinase activity | 18440775 |
| Hgene | VEGFA | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 9202027|18440775|20497126 |
| Hgene | VEGFA | GO:0045766 | positive regulation of angiogenesis | 18440775|18577655|19033661|20497126 |
| Hgene | VEGFA | GO:0045785 | positive regulation of cell adhesion | 19674970 |
| Hgene | VEGFA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18059339 |
| Hgene | VEGFA | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 21245381 |
| Hgene | VEGFA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 10022831|16489009|21245381 |
| Hgene | VEGFA | GO:0050918 | positive chemotaxis | 20497126 |
| Hgene | VEGFA | GO:0050927 | positive regulation of positive chemotaxis | 7929439|12744932 |
| Hgene | VEGFA | GO:0051272 | positive regulation of cellular component movement | 10527820|12744932 |
| Hgene | VEGFA | GO:0051894 | positive regulation of focal adhesion assembly | 16489009 |
| Hgene | VEGFA | GO:0071456 | cellular response to hypoxia | 10575000 |
| Hgene | VEGFA | GO:0090037 | positive regulation of protein kinase C signaling | 18059339 |
| Hgene | VEGFA | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | 20551324 |
| Hgene | VEGFA | GO:0097533 | cellular stress response to acid chemical | 26299712 |
| Hgene | VEGFA | GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation | 20660291 |
| Hgene | VEGFA | GO:1900745 | positive regulation of p38MAPK cascade | 18386220 |
| Hgene | VEGFA | GO:1901727 | positive regulation of histone deacetylase activity | 20497126 |
| Hgene | VEGFA | GO:1903572 | positive regulation of protein kinase D signaling | 20497126 |
| Hgene | VEGFA | GO:1903672 | positive regulation of sprouting angiogenesis | 26299712 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI869727 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000372067 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000417285 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| intron-intron | ENST00000324450 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000413642 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000372055 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000482630 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000425836 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| intron-intron | ENST00000372064 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| intron-intron | ENST00000372077 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000520948 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000523873 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000523950 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000518689 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000523125 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| intron-intron | ENST00000457104 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000518824 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
| 5CDS-intron | ENST00000230480 | ENST00000390394 | VEGFA | chr6 | 43749719 | + | TRBV20-1 | chr16 | 2009600 | + |
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FusionProtFeatures for VEGFA_TRBV20-1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VEGFA | TRBV20-1 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VEGFA_TRBV20-1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VEGFA_TRBV20-1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VEGFA_TRBV20-1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | VEGFA | P15692 | DB01120 | Gliclazide | Vascular endothelial growth factor A | small molecule | approved |
| Hgene | VEGFA | P15692 | DB01270 | Ranibizumab | Vascular endothelial growth factor A | biotech | approved |
| Hgene | VEGFA | P15692 | DB03754 | Tromethamine | Vascular endothelial growth factor A | small molecule | approved |
| Hgene | VEGFA | P15692 | DB05294 | Vandetanib | Vascular endothelial growth factor A | small molecule | approved |
| Hgene | VEGFA | P15692 | DB06779 | Dalteparin | Vascular endothelial growth factor A | small molecule | approved |
| Hgene | VEGFA | P15692 | DB08885 | Aflibercept | Vascular endothelial growth factor A | biotech | approved |
| Hgene | VEGFA | P15692 | DB00112 | Bevacizumab | Vascular endothelial growth factor A | biotech | approved|investigational |
| Hgene | VEGFA | P15692 | DB01017 | Minocycline | Vascular endothelial growth factor A | small molecule | approved|investigational |
| Hgene | VEGFA | P15692 | DB01136 | Carvedilol | Vascular endothelial growth factor A | small molecule | approved|investigational |
| Hgene | VEGFA | P15692 | DB09301 | Chondroitin sulfate | Vascular endothelial growth factor A | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for VEGFA_TRBV20-1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | VEGFA | C0011570 | Mental Depression | 5 | PSYGENET |
| Hgene | VEGFA | C0011581 | Depressive disorder | 5 | PSYGENET |
| Hgene | VEGFA | C0151744 | Myocardial Ischemia | 5 | CTD_human |
| Hgene | VEGFA | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Hgene | VEGFA | C0033578 | Prostatic Neoplasms | 4 | CTD_human |
| Hgene | VEGFA | C0004096 | Asthma | 3 | CTD_human |
| Hgene | VEGFA | C0011884 | Diabetic Retinopathy | 3 | CTD_human |
| Hgene | VEGFA | C0027627 | Neoplasm Metastasis | 3 | CTD_human |
| Hgene | VEGFA | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | VEGFA | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
| Hgene | VEGFA | C0018801 | Heart failure | 2 | CTD_human |
| Hgene | VEGFA | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Hgene | VEGFA | C0027659 | Neoplasms, Experimental | 2 | CTD_human |
| Hgene | VEGFA | C0027686 | Pathologic Neovascularization | 2 | CTD_human |
| Hgene | VEGFA | C0525045 | Mood Disorders | 2 | PSYGENET |
| Hgene | VEGFA | C0993582 | Arthritis, Experimental | 2 | CTD_human |
| Hgene | VEGFA | C1956346 | Coronary Artery Disease | 2 | CTD_human |
| Hgene | VEGFA | C2609414 | Acute kidney injury | 2 | CTD_human |
| Hgene | VEGFA | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | VEGFA | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Hgene | VEGFA | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | VEGFA | C0004153 | Atherosclerosis | 1 | CTD_human |
| Hgene | VEGFA | C0006118 | Brain Neoplasms | 1 | CTD_human |
| Hgene | VEGFA | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | VEGFA | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Hgene | VEGFA | C0008677 | Bronchitis, Chronic | 1 | CTD_human |
| Hgene | VEGFA | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | VEGFA | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Hgene | VEGFA | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Hgene | VEGFA | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
| Hgene | VEGFA | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | VEGFA | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| Hgene | VEGFA | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | VEGFA | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Hgene | VEGFA | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Hgene | VEGFA | C0018799 | Heart Diseases | 1 | CTD_human |
| Hgene | VEGFA | C0018923 | Hemangiosarcoma | 1 | CTD_human |
| Hgene | VEGFA | C0020541 | Hypertension, Portal | 1 | CTD_human |
| Hgene | VEGFA | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | VEGFA | C0023186 | Learning Disorders | 1 | CTD_human |
| Hgene | VEGFA | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Hgene | VEGFA | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | VEGFA | C0024115 | Lung diseases | 1 | CTD_human |
| Hgene | VEGFA | C0025261 | Memory Disorders | 1 | CTD_human |
| Hgene | VEGFA | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
| Hgene | VEGFA | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Hgene | VEGFA | C0029422 | Osteochondrodysplasias | 1 | CTD_human |
| Hgene | VEGFA | C0029463 | Osteosarcoma | 1 | CTD_human |
| Hgene | VEGFA | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | VEGFA | C0033687 | Proteinuria | 1 | CTD_human |
| Hgene | VEGFA | C0033860 | Psoriasis | 1 | CTD_human |
| Hgene | VEGFA | C0035309 | Retinal Diseases | 1 | CTD_human |
| Hgene | VEGFA | C0035328 | Retinal Vein Occlusion | 1 | CTD_human |
| Hgene | VEGFA | C0035412 | Rhabdomyosarcoma | 1 | CTD_human |
| Hgene | VEGFA | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | VEGFA | C0038220 | Status Epilepticus | 1 | CTD_human |
| Hgene | VEGFA | C0038358 | Gastric ulcer | 1 | CTD_human |
| Hgene | VEGFA | C0042076 | Urologic Neoplasms | 1 | CTD_human |
| Hgene | VEGFA | C0085109 | Corneal Neovascularization | 1 | CTD_human |
| Hgene | VEGFA | C0085605 | Liver Failure | 1 | CTD_human |
| Hgene | VEGFA | C0206726 | gliosarcoma | 1 | CTD_human |
| Hgene | VEGFA | C0242350 | Erectile dysfunction | 1 | CTD_human |
| Hgene | VEGFA | C0242383 | Age related macular degeneration | 1 | CTD_human |
| Hgene | VEGFA | C0271051 | Macular retinal edema | 1 | CTD_human |
| Hgene | VEGFA | C0342257 | Complications of Diabetes Mellitus | 1 | CTD_human |
| Hgene | VEGFA | C0600518 | Choroidal Neovascularization | 1 | CTD_human |
| Hgene | VEGFA | C0678807 | prenatal alcohol exposure | 1 | PSYGENET |
| Hgene | VEGFA | C0752308 | Hypoxia-Ischemia, Brain | 1 | CTD_human |
| Hgene | VEGFA | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
| Hgene | VEGFA | C2063866 | Depressive Disorder, Treatment-Resistant | 1 | PSYGENET |
| Hgene | VEGFA | C2717961 | Thrombotic Microangiopathies | 1 | CTD_human |
| Hgene | VEGFA | C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | CTD_human |
| Hgene | VEGFA | C2937358 | Cerebral Hemorrhage | 1 | CTD_human |
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