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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41398

FusionGeneSummary for VCL_PLAU

check button Fusion gene summary
Fusion gene informationFusion gene name: VCL_PLAU
Fusion gene ID: 41398
HgeneTgene
Gene symbol

VCL

PLAU

Gene ID

7414

5328

Gene namevinculinplasminogen activator, urokinase
SynonymsCMD1W|CMH15|HEL114|MV|MVCLATF|BDPLT5|QPD|UPA|URK|u-PA
Cytomap

10q22.2

10q22.2

Type of geneprotein-codingprotein-coding
Descriptionvinculinepididymis luminal protein 114meta-vinculinmetavinculinurokinase-type plasminogen activatorU-plasminogen activatorplasminogen activator, urinary
Modification date2018052220180527
UniProtAcc

P18206

P00749

Ensembl transtripts involved in fusion geneENST00000211998, ENST00000372755, 
ENST00000478896, ENST00000417648, 
ENST00000446342, ENST00000494287, 
ENST00000372764, ENST00000372762, 
Fusion gene scores* DoF score10 X 7 X 10=7001 X 1 X 1=1
# samples 121
** MAII scorelog2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: VCL [Title/Abstract] AND PLAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAU

GO:0010469

regulation of signaling receptor activity

8837777

TgenePLAU

GO:0014910

regulation of smooth muscle cell migration

8837777

TgenePLAU

GO:0030335

positive regulation of cell migration

25168896

TgenePLAU

GO:0031639

plasminogen activation

25978044

TgenePLAU

GO:0033628

regulation of cell adhesion mediated by integrin

8837777

TgenePLAU

GO:2000097

regulation of smooth muscle cell-matrix adhesion

8837777


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A256-01AVCLchr10

75758133

+PLAUchr10

75674534

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000211998ENST00000446342VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000211998ENST00000494287VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000211998ENST00000372764VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000211998ENST00000372762VCLchr10

75758133

+PLAUchr10

75674534

+
Frame-shiftENST00000372755ENST00000446342VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000372755ENST00000494287VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000372755ENST00000372764VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000372755ENST00000372762VCLchr10

75758133

+PLAUchr10

75674534

+
3UTR-3CDSENST00000478896ENST00000446342VCLchr10

75758133

+PLAUchr10

75674534

+
3UTR-intronENST00000478896ENST00000494287VCLchr10

75758133

+PLAUchr10

75674534

+
3UTR-intronENST00000478896ENST00000372764VCLchr10

75758133

+PLAUchr10

75674534

+
3UTR-intronENST00000478896ENST00000372762VCLchr10

75758133

+PLAUchr10

75674534

+
Frame-shiftENST00000417648ENST00000446342VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000417648ENST00000494287VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000417648ENST00000372764VCLchr10

75758133

+PLAUchr10

75674534

+
5CDS-intronENST00000417648ENST00000372762VCLchr10

75758133

+PLAUchr10

75674534

+

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FusionProtFeatures for VCL_PLAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VCL

P18206

PLAU

P00749

Actin filament (F-actin)-binding protein involved incell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing bythe E-cadherin complex. May also play important roles in cellmorphology and locomotion. {ECO:0000269|PubMed:20484056}. Specifically cleaves the zymogen plasminogen to form theactive enzyme plasmin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VCL_PLAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VCL_PLAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VCLABI2, C19orf57, TRIP6, CDH1, CTNNB1, PSME1, CORO2B, TGFB1I1, NRAP, PXN, GSN, BCAR1, VASP, SORBS1, SORBS2, CTNNA1, CLTC, DAG1, TUBA1A, SIRT7, CDK2, ITGB1, DNAJC5, TXNL1, SCAF4, URM1, ZC3HAV1L, SVIL, SSU72, SDHAF2, UBR1, VAPB, PGM5, USO1, ATP6V1A, UBA3, TPI1, UFC1, VCP, VCAM1, FN1, PRPF40A, ITGA4, ASNS, CTPS1, ECHS1, EIF5, FERMT2, GINS3, GSS, HSPA5, HSPA9, MSN, PDCD10, PDHA1, PDIA4, PPP1R2, PPP5C, RAP1GDS1, SFN, SNRPF, STK24, TUBB3, UBFD1, DCPS, ERP44, G6PD, GNAI3, ISOC1, PFAS, TBCB, XPO1, YWHAE, YWHAG, YWHAQ, YWHAZ, YWHAH, ASB7, VCL, TEKT1, UNK, PICALM, NTRK1, SELE, EWSR1, FBF1, LPXN, ACTG1, CAPZB, MYO1C, RPS27A, SPTAN1, TLN1, MKNK2, SEC16A, CDCA5, MPDZ, AP3M1, LIMA1, PPHLN1, RBM26, GKAP1, ASCC2, TRIM15, PAK4, FOCAD, TTC21B, UBE2N, HSD17B10, TRIM25, BRCA1PLAUSERPINE1, SERPINE2, PLAT, SERPINA5, PLAUR, LRP2, SERPINB2, MAP2K1, HRAS, PDGFC, SCAMP5, ELAVL1, CEBPG, BTK, ALAS1, MYC, TEX101, MOCOS, PPP4R4, KAT8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VCL_PLAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePLAUP00749DB00594AmilorideUrokinase-type plasminogen activatorsmall moleculeapproved
TgenePLAUP00749DB00013UrokinaseUrokinase-type plasminogen activatorbiotechapproved|investigational|withdrawn

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RelatedDiseases for VCL_PLAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVCLC1969639Cardiomyopathy, Dilated, 1w2CTD_human;UNIPROT
HgeneVCLC0029456Osteoporosis1CTD_human
HgeneVCLC0948089Acute Coronary Syndrome1CTD_human
HgeneVCLC2750459CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 151CTD_human;UNIPROT
TgenePLAUC0027051Myocardial Infarction6CTD_human
TgenePLAUC0034065Pulmonary Embolism6CTD_human
TgenePLAUC0040053Thrombosis6CTD_human
TgenePLAUC2937358Cerebral Hemorrhage5CTD_human
TgenePLAUC0003838Arterial Occlusive Diseases4CTD_human
TgenePLAUC0007786Brain Ischemia4CTD_human
TgenePLAUC0018128Graft Occlusion, Vascular4CTD_human
TgenePLAUC0019080Hemorrhage4CTD_human
TgenePLAUC0042487Venous Thrombosis4CTD_human
TgenePLAUC0151699Intracranial Hemorrhages4CTD_human
TgenePLAUC0007785Cerebral Infarction3CTD_human
TgenePLAUC0033578Prostatic Neoplasms3CTD_human
TgenePLAUC0740392Infarction, Middle Cerebral Artery3CTD_human
TgenePLAUC0007820Cerebrovascular Disorders2CTD_human
TgenePLAUC0010068Coronary heart disease2CTD_human
TgenePLAUC0022116Ischemia2CTD_human
TgenePLAUC0023890Liver Cirrhosis2CTD_human
TgenePLAUC0027626Neoplasm Invasiveness2CTD_human
TgenePLAUC0034152Henoch-Schoenlein Purpura2CTD_human
TgenePLAUC0001418Adenocarcinoma1CTD_human
TgenePLAUC0002962Angina Pectoris1CTD_human
TgenePLAUC0002965Angina, Unstable1CTD_human
TgenePLAUC0003460Anuria1CTD_human
TgenePLAUC0004096Asthma1CTD_human
TgenePLAUC0005967Bone neoplasms1CTD_human
TgenePLAUC0007138Carcinoma, Transitional Cell1CTD_human
TgenePLAUC0007273Carotid Artery Diseases1CTD_human
TgenePLAUC0007781Intracranial Embolism and Thrombosis1CTD_human
TgenePLAUC0017661IGA Glomerulonephritis1CTD_human
TgenePLAUC0018814Heart Rupture, Post-Infarction1CTD_human
TgenePLAUC0018965Hematuria1CTD_human
TgenePLAUC0020649Hypotension1CTD_human
TgenePLAUC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePLAUC0027627Neoplasm Metastasis1CTD_human
TgenePLAUC0027643Neoplasm Recurrence, Local1CTD_human
TgenePLAUC0027697Nephritis1CTD_human
TgenePLAUC0030297Pancreatic Neoplasm1CTD_human
TgenePLAUC0035126Reperfusion Injury1CTD_human
TgenePLAUC0038356Stomach Neoplasms1CTD_human
TgenePLAUC0038454Cerebrovascular accident1CTD_human
TgenePLAUC0040038Thromboembolism1CTD_human
TgenePLAUC0042510Ventricular Fibrillation1CTD_human
TgenePLAUC0149649Cholesterol Embolism1CTD_human
TgenePLAUC0338575Sagittal Sinus Thrombosis1CTD_human
TgenePLAUC0403823Asthenozoospermia1CTD_human
TgenePLAUC1527311Brain Edema1CTD_human
TgenePLAUC1800706Idiopathic Pulmonary Fibrosis1CTD_human