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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41389

FusionGeneSummary for VBP1_GABRA3

check button Fusion gene summary
Fusion gene informationFusion gene name: VBP1_GABRA3
Fusion gene ID: 41389
HgeneTgene
Gene symbol

VBP1

GABRA3

Gene ID

7411

2556

Gene nameVHL binding protein 1gamma-aminobutyric acid type A receptor alpha3 subunit
SynonymsHIBBJ46|PFD3|PFDN3|VBP-1-
Cytomap

Xq28

Xq28

Type of geneprotein-codingprotein-coding
Descriptionprefoldin subunit 3von Hippel-Lindau binding protein 1gamma-aminobutyric acid receptor subunit alpha-3GABA(A) receptor subunit alpha-3GABA(A) receptor, alpha 3gamma-aminobutyric acid (GABA) A receptor, alpha 3gamma-animobutyric acid (GABA) A receptor, alpha 3
Modification date2018052320180523
UniProtAcc

P61758

P34903

Ensembl transtripts involved in fusion geneENST00000535916, ENST00000286428, 
ENST00000459836, 
ENST00000370314, 
ENST00000535043, ENST00000497894, 
Fusion gene scores* DoF score3 X 2 X 4=246 X 5 X 5=150
# samples 46
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VBP1 [Title/Abstract] AND GABRA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-6712-01AVBP1chrX

154444852

+GABRA3chrX

151393317

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000535916ENST00000370314VBP1chrX

154444852

+GABRA3chrX

151393317

-
intron-3CDSENST00000535916ENST00000535043VBP1chrX

154444852

+GABRA3chrX

151393317

-
intron-intronENST00000535916ENST00000497894VBP1chrX

154444852

+GABRA3chrX

151393317

-
Frame-shitENST00000286428ENST00000370314VBP1chrX

154444852

+GABRA3chrX

151393317

-
Frame-shitENST00000286428ENST00000535043VBP1chrX

154444852

+GABRA3chrX

151393317

-
5CDS-intronENST00000286428ENST00000497894VBP1chrX

154444852

+GABRA3chrX

151393317

-
intron-3CDSENST00000459836ENST00000370314VBP1chrX

154444852

+GABRA3chrX

151393317

-
intron-3CDSENST00000459836ENST00000535043VBP1chrX

154444852

+GABRA3chrX

151393317

-
intron-intronENST00000459836ENST00000497894VBP1chrX

154444852

+GABRA3chrX

151393317

-

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FusionProtFeatures for VBP1_GABRA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VBP1

P61758

GABRA3

P34903

Binds specifically to cytosolic chaperonin (c-CPN) andtransfers target proteins to it. Binds to nascent polypeptidechain and promotes folding in an environment in which there aremany competing pathways for nonnative proteins.{ECO:0000269|PubMed:9630229}. GABA, the major inhibitory neurotransmitter in thevertebrate brain, mediates neuronal inhibition by binding to theGABA/benzodiazepine receptor and opening an integral chloridechannel.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VBP1_GABRA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VBP1_GABRA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VBP1VHL, PFDN2, MSH4, PAN2, PRPF4, PPP2CB, TUBA3E, XRCC6, PIK3R3, FBXW8, MKNK2, PFDN4, PFDN5, PFDN6, KARS, EPRS, GARS, NUBP2, NAB2, IARS, DARS, CLNS1A, QARS, TRMT1, PSMC2, METTL21B, HDAC1, VCP, MAPK7, SSB, TNPO1, UBQLN2, ANP32A, ARPC1B, ARPC4, PPP3CA, RABGGTA, TTLL12, FKBP6, PNMA1, UBL7, DCAF5, PEX7, CBS, FLNA, TXNDC12, DCUN1D1, FLNB, GOLPH3, PFDN1, RNASEH2B, SEC24B, XPNPEP1, BTRC, EWSR1, POC1A, POC1B, ANAPC15, PTPN21, DUSP16, DUSP8, DUSP9, MTM1, PHKB, COPRS, CCDC101, SUPT6H, PDRG1, STK26, GSPT1, GNB2GABRA3UBQLN1, UGT2B7, SDCBP2, EGFR, GABRA5, ABCA7, SEC11C, TMEM131, GLRB, TUSC3, AMIGO1, TMEM59L, TTC17, EDA, POMT1, SPCS1, WLS, ALG9, SLC47A1, HLA-C, GPAA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VBP1_GABRA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGABRA3P34903DB00425ZolpidemGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB00546AdinazolamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB00849MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB01354HeptabarbitalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB01355HexobarbitalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB01594CinolazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB09166EtizolamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB13872LormetazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved
TgeneGABRA3P34903DB00306TalbutalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01351AmobarbitalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01352AprobarbitalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01353ButethalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01559ClotiazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01567FludiazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01588PrazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB01589QuazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit
TgeneGABRA3P34903DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit|investigational
TgeneGABRA3P34903DB01558BromazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit|investigational
TgeneGABRA3P34903DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit|investigational|vet_approved
TgeneGABRA3P34903DB00801HalazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|illicit|withdrawn
TgeneGABRA3P34903DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|investigational
TgeneGABRA3P34903DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|investigational
TgeneGABRA3P34903DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|investigational
TgeneGABRA3P34903DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|investigational|vet_approved
TgeneGABRA3P34903DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|vet_approved
TgeneGABRA3P34903DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|vet_approved
TgeneGABRA3P34903DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-3small moleculeapproved|vet_approved

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RelatedDiseases for VBP1_GABRA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGABRA3C0005586Bipolar Disorder5PSYGENET
TgeneGABRA3C0004352Autistic Disorder1CTD_human
TgeneGABRA3C0011570Mental Depression1PSYGENET
TgeneGABRA3C0011581Depressive disorder1PSYGENET