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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41383

FusionGeneSummary for VAV3_RGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: VAV3_RGL1
Fusion gene ID: 41383
HgeneTgene
Gene symbol

VAV3

RGL1

Gene ID

10451

64333

Gene namevav guanine nucleotide exchange factor 3Rho GTPase activating protein 9
Synonyms-10C|RGL1
Cytomap

1p13.3

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide exchange factor VAV3VAV-3vav 3 guanine nucleotide exchange factorvav 3 oncogenerho GTPase-activating protein 9rho-type GTPase-activating protein 9
Modification date2018051920180523
UniProtAcc

Q9UKW4

Q9NZL6

Ensembl transtripts involved in fusion geneENST00000370056, ENST00000527011, 
ENST00000544443, ENST00000415432, 
ENST00000343258, ENST00000371846, 
ENST00000304685, ENST00000536277, 
ENST00000360851, ENST00000539189, 
Fusion gene scores* DoF score5 X 6 X 2=606 X 5 X 5=150
# samples 66
** MAII scorelog2(6/60*10)=0log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VAV3 [Title/Abstract] AND RGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1LA-01AVAV3chr1

108291590

-RGL1chr1

183666538

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000370056ENST00000304685VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-5UTRENST00000370056ENST00000536277VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000370056ENST00000360851VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000370056ENST00000539189VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000527011ENST00000304685VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-5UTRENST00000527011ENST00000536277VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000527011ENST00000360851VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000527011ENST00000539189VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-intronENST00000544443ENST00000304685VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-5UTRENST00000544443ENST00000536277VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-intronENST00000544443ENST00000360851VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-intronENST00000544443ENST00000539189VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-intronENST00000415432ENST00000304685VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-5UTRENST00000415432ENST00000536277VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-intronENST00000415432ENST00000360851VAV3chr1

108291590

-RGL1chr1

183666538

+
intron-intronENST00000415432ENST00000539189VAV3chr1

108291590

-RGL1chr1

183666538

+
5UTR-intronENST00000343258ENST00000304685VAV3chr1

108291590

-RGL1chr1

183666538

+
5UTR-5UTRENST00000343258ENST00000536277VAV3chr1

108291590

-RGL1chr1

183666538

+
5UTR-intronENST00000343258ENST00000360851VAV3chr1

108291590

-RGL1chr1

183666538

+
5UTR-intronENST00000343258ENST00000539189VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000371846ENST00000304685VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-5UTRENST00000371846ENST00000536277VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000371846ENST00000360851VAV3chr1

108291590

-RGL1chr1

183666538

+
5CDS-intronENST00000371846ENST00000539189VAV3chr1

108291590

-RGL1chr1

183666538

+

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FusionProtFeatures for VAV3_RGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VAV3

Q9UKW4

RGL1

Q9NZL6

Probable guanine nucleotide exchange factor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VAV3_RGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VAV3_RGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VAV3GRB2, PDGFRB, EGFR, RAC1, RHOA, RHOG, ROS1, INSR, IGF1R, SHC1, BLNK, ESR1, ERBB2, ERBB3, TRAF6, TNFRSF11A, TRAF1, TRAF3RGL1HRAS, APP, FBXL13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VAV3_RGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VAV3_RGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVAV3C0017661IGA Glomerulonephritis1CTD_human
HgeneVAV3C0020538Hypertensive disease1CTD_human
HgeneVAV3C0020578Hyperventilation1CTD_human
HgeneVAV3C0033578Prostatic Neoplasms1CTD_human
HgeneVAV3C0039231Tachycardia1CTD_human