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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41370

FusionGeneSummary for VAV1_C1orf198

check button Fusion gene summary
Fusion gene informationFusion gene name: VAV1_C1orf198
Fusion gene ID: 41370
HgeneTgene
Gene symbol

VAV1

C1orf198

Gene ID

7409

84886

Gene namevav guanine nucleotide exchange factor 1chromosome 1 open reading frame 198
SynonymsVAV-
Cytomap

19p13.3

1q42.2

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene vavvav 1 guanine nucleotide exchange factorvav 1 oncogeneuncharacterized protein C1orf198
Modification date2018051920180519
UniProtAcc

P15498

Q9H425

Ensembl transtripts involved in fusion geneENST00000304076, ENST00000602142, 
ENST00000596764, ENST00000539284, 
ENST00000599806, 
ENST00000366663, 
ENST00000470540, ENST00000427697, 
ENST00000523410, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: VAV1 [Title/Abstract] AND C1orf198 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A11A-01AVAV1chr19

6843177

+C1orf198chr1

230975654

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000304076ENST00000366663VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000304076ENST00000470540VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000304076ENST00000427697VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000304076ENST00000523410VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000602142ENST00000366663VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000602142ENST00000470540VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000602142ENST00000427697VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000602142ENST00000523410VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000596764ENST00000366663VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000596764ENST00000470540VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000596764ENST00000427697VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000596764ENST00000523410VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000539284ENST00000366663VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000539284ENST00000470540VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000539284ENST00000427697VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000539284ENST00000523410VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000599806ENST00000366663VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000599806ENST00000470540VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000599806ENST00000427697VAV1chr19

6843177

+C1orf198chr1

230975654

-
Frame-shiftENST00000599806ENST00000523410VAV1chr19

6843177

+C1orf198chr1

230975654

-

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FusionProtFeatures for VAV1_C1orf198


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VAV1

P15498

C1orf198

Q9H425

Couples tyrosine kinase signals with the activation ofthe Rho/Rac GTPases, thus leading to cell differentiation and/orproliferation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VAV1_C1orf198


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VAV1_C1orf198


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VAV1XRCC6, EZH2, EMD, PRKCQ, BLNK, PLCG1, PIK3R1, XRCC5, TYK2, TEC, PRLR, RAC1, CDC42, JUN, SOCS1, EPOR, JAK2, BTK, SH3BP2, PDGFRB, EGFR, SLA, SHB, LAT, ABL1, RACGAP1, SYK, RAF1, MAPK1, MAP2K1, GRB2, ARHGDIB, FYN, HNRNPK, PAG1, CBLB, CBL, CD19, LCP2, PTPN6, SIAH2, SIAH1, IL6ST, S100B, ZAP70, PLCG2, PTK2B, DOCK2, INSR, SUZ12, EED, PHAX, TUBA1A, TUBB, KHDRBS1, FGFR1, DOK1, NOTCH1, CD5, SPI1, PTPN22, ERBB2, ERBB3, CD28, MS4A2, KLK7, PLBD1, NUB1, SPECC1L, SERPINA12, PALM2-AKAP2, APLP2, ACTBL2, SDR9C7, SERPINB2, APBB2, CDSN, ACTA2, CST6, DNAJC1, SBSN, DSG1, ATP2B2, CHEK1C1orf198ELAVL1, RHOD, FGL1, EWSR1, CEP128, NINL, SCLT1, XPO1, CEP170P1, CDH1, RHOC, SERPINB13, ARMC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VAV1_C1orf198


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VAV1_C1orf198


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVAV1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneVAV1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneVAV1C0025149Medulloblastoma1CTD_human
HgeneVAV1C0152013Adenocarcinoma of lung (disorder)1CTD_human