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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41334

FusionGeneSummary for VANGL1_PARP12

check button Fusion gene summary
Fusion gene informationFusion gene name: VANGL1_PARP12
Fusion gene ID: 41334
HgeneTgene
Gene symbol

VANGL1

PARP12

Gene ID

81839

64761

Gene nameVANGL planar cell polarity protein 1poly(ADP-ribose) polymerase family member 12
SynonymsKITENIN|LPP2|STB2|STBM2ARTD12|MST109|MSTP109|ZC3H1|ZC3HDC1
Cytomap

1p13.1

7q34

Type of geneprotein-codingprotein-coding
Descriptionvang-like protein 1KAI1 C-terminal interacting tetraspaninloop-tail protein 2 homologstrabismus 2van Gogh-like protein 1vang-like 1 (van gogh, Drosophila)poly [ADP-ribose] polymerase 12ADP-ribosyltransferase diphtheria toxin-like 12zinc finger CCCH type domain containing 1
Modification date2018051920180519
UniProtAcc

Q8TAA9

Q9H0J9

Ensembl transtripts involved in fusion geneENST00000355485, ENST00000369510, 
ENST00000310260, ENST00000369509, 
ENST00000474344, 
ENST00000263549, 
ENST00000470515, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 4 X 2=24
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VANGL1 [Title/Abstract] AND PARP12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DR423509VANGL1chr1

116194106

+PARP12chr7

139737657

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355485ENST00000263549VANGL1chr1

116194106

+PARP12chr7

139737657

-
5CDS-5UTRENST00000355485ENST00000470515VANGL1chr1

116194106

+PARP12chr7

139737657

-
Frame-shiftENST00000369510ENST00000263549VANGL1chr1

116194106

+PARP12chr7

139737657

-
5CDS-5UTRENST00000369510ENST00000470515VANGL1chr1

116194106

+PARP12chr7

139737657

-
Frame-shiftENST00000310260ENST00000263549VANGL1chr1

116194106

+PARP12chr7

139737657

-
5CDS-5UTRENST00000310260ENST00000470515VANGL1chr1

116194106

+PARP12chr7

139737657

-
Frame-shiftENST00000369509ENST00000263549VANGL1chr1

116194106

+PARP12chr7

139737657

-
5CDS-5UTRENST00000369509ENST00000470515VANGL1chr1

116194106

+PARP12chr7

139737657

-
intron-3CDSENST00000474344ENST00000263549VANGL1chr1

116194106

+PARP12chr7

139737657

-
intron-5UTRENST00000474344ENST00000470515VANGL1chr1

116194106

+PARP12chr7

139737657

-

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FusionProtFeatures for VANGL1_PARP12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VANGL1

Q8TAA9

PARP12

Q9H0J9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VANGL1_PARP12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VANGL1_PARP12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VANGL1KBTBD7, RAPGEF5, NT5C3A, GMFG, SMYD3, THAP2, SRPK1, FBXW11, CCDC8, SPRY2, ZRANB2, LUC7L, EPB41L3, RASSF9, RASSF10, TCTN3, EVC2, TMEM17, TMEM216, NAF1, VANGL2, PTPN3, GPR156, CD44, DVL3, SDC2, PNN, TNFRSF1A, MANSC1, SDC1, PRICKLE3, NXF2, EPB41L5, CD83, JPH4, FGF8, ZC3H18, TRIM25, RNF41, ERBB4PARP12BCL6, ELAVL1, MLH1, CBX2, CBX4, RPA3, RPA2, RPA1, RNF2, KRAS, XPO1, BHLHA15, RNF166, GCLM, MKRN2, RNF114, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VANGL1_PARP12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VANGL1_PARP12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVANGL1C0027794Neural Tube Defects2CTD_human
HgeneVANGL1C1838568Sacral defect and anterior sacral meningocele1CTD_human;UNIPROT
HgeneVANGL1C3891448NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO1UNIPROT
TgenePARP12C0021400Influenza1CTD_human