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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41325

FusionGeneSummary for VAMP2_ACTB

check button Fusion gene summary
Fusion gene informationFusion gene name: VAMP2_ACTB
Fusion gene ID: 41325
HgeneTgene
Gene symbol

VAMP2

ACTB

Gene ID

6844

60

Gene namevesicle associated membrane protein 2actin beta
SynonymsSYB2|VAMP-2BRWS1|PS1TP5BP1
Cytomap

17p13.1

7p22.1

Type of geneprotein-codingprotein-coding
Descriptionvesicle-associated membrane protein 2synaptobrevin 2actin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin
Modification date2018052320180522
UniProtAcc

P63027

P60709

Ensembl transtripts involved in fusion geneENST00000316509, ENST00000404970, 
ENST00000488857, ENST00000481878, 
ENST00000464611, ENST00000331789, 
Fusion gene scores* DoF score5 X 5 X 1=2510 X 10 X 3=300
# samples 511
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VAMP2 [Title/Abstract] AND ACTB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACTB

GO:0098974

postsynaptic actin cytoskeleton organization

18341992


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI019526VAMP2chr17

8066213

-ACTBchr7

5567037

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000316509ENST00000464611VAMP2chr17

8066213

-ACTBchr7

5567037

-
intron-3UTRENST00000316509ENST00000331789VAMP2chr17

8066213

-ACTBchr7

5567037

-
intron-5UTRENST00000404970ENST00000464611VAMP2chr17

8066213

-ACTBchr7

5567037

-
intron-3UTRENST00000404970ENST00000331789VAMP2chr17

8066213

-ACTBchr7

5567037

-
intron-5UTRENST00000488857ENST00000464611VAMP2chr17

8066213

-ACTBchr7

5567037

-
intron-3UTRENST00000488857ENST00000331789VAMP2chr17

8066213

-ACTBchr7

5567037

-
intron-5UTRENST00000481878ENST00000464611VAMP2chr17

8066213

-ACTBchr7

5567037

-
intron-3UTRENST00000481878ENST00000331789VAMP2chr17

8066213

-ACTBchr7

5567037

-

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FusionProtFeatures for VAMP2_ACTB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VAMP2

P63027

ACTB

P60709

Involved in the targeting and/or fusion of transportvesicles to their target membrane. Modulates the gatingcharacteristics of the delayed rectifier voltage-dependentpotassium channel KCNB1. {ECO:0000250|UniProtKB:P63045}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VAMP2_ACTB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VAMP2_ACTB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VAMP2_ACTB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneVAMP2P63027DB00042Botulinum Toxin Type BVesicle-associated membrane protein 2biotechapproved|investigational

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RelatedDiseases for VAMP2_ACTB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVAMP2C0005586Bipolar Disorder1PSYGENET
HgeneVAMP2C0036341Schizophrenia1PSYGENET
HgeneVAMP2C0041696Unipolar Depression1PSYGENET
HgeneVAMP2C1269683Major Depressive Disorder1PSYGENET
HgeneVAMP2C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET
TgeneACTBC2239176Liver carcinoma2CTD_human
TgeneACTBC0005586Bipolar Disorder1PSYGENET
TgeneACTBC0009363Congenital ocular coloboma (disorder)1CTD_human
TgeneACTBC0013393Dysostoses1CTD_human
TgeneACTBC0013421Dystonia1CTD_human
TgeneACTBC0014859Esophageal Neoplasms1CTD_human
TgeneACTBC0018784Sensorineural Hearing Loss (disorder)1CTD_human;HPO
TgeneACTBC0024121Lung Neoplasms1CTD_human
TgeneACTBC0024667Animal Mammary Neoplasms1CTD_human
TgeneACTBC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneACTBC0027626Neoplasm Invasiveness1CTD_human
TgeneACTBC0029408Degenerative polyarthritis1CTD_human
TgeneACTBC0036341Schizophrenia1PSYGENET
TgeneACTBC0151744Myocardial Ischemia1CTD_human
TgeneACTBC0242184Hypoxia1CTD_human
TgeneACTBC0376634Craniofacial Abnormalities1CTD_human
TgeneACTBC0497552Congenital neurologic anomalies1CTD_human
TgeneACTBC1846331Juvenile-onset dystonia1CTD_human;ORPHANET;UNIPROT
TgeneACTBC1855722Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation1ORPHANET;UNIPROT