FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41316

FusionGeneSummary for UXS1_TMEM241

check button Fusion gene summary
Fusion gene informationFusion gene name: UXS1_TMEM241
Fusion gene ID: 41316
HgeneTgene
Gene symbol

UXS1

TMEM241

Gene ID

80146

85019

Gene nameUDP-glucuronate decarboxylase 1transmembrane protein 241
SynonymsSDR6E1|UGDC18orf45|hVVT
Cytomap

2q12.2

18q11.2

Type of geneprotein-codingprotein-coding
DescriptionUDP-glucuronic acid decarboxylase 1UXS-1short chain dehydrogenase/reductase family 6E, member 12transmembrane protein 241putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2putative vertebrate vrg4-like nucleotide-sugar transporter variant1transmembrane protein C18orf45
Modification date2018052320180519
UniProtAcc

Q8NBZ7

Q24JQ0

Ensembl transtripts involved in fusion geneENST00000283148, ENST00000540130, 
ENST00000409501, ENST00000409032, 
ENST00000428048, ENST00000479621, 
ENST00000450466, ENST00000383233, 
ENST00000542162, ENST00000399707, 
ENST00000475185, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 5 X 6=180
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UXS1 [Title/Abstract] AND TMEM241 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUXS1

GO:0051262

protein tetramerization

23656592


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CQ-A4C9-01AUXS1chr2

106774514

-TMEM241chr18

20979611

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283148ENST00000450466UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000283148ENST00000383233UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000283148ENST00000542162UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000283148ENST00000399707UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000283148ENST00000475185UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000540130ENST00000450466UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000540130ENST00000383233UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000540130ENST00000542162UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000540130ENST00000399707UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000540130ENST00000475185UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000409501ENST00000450466UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000409501ENST00000383233UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000409501ENST00000542162UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000409501ENST00000399707UXS1chr2

106774514

-TMEM241chr18

20979611

-
5CDS-intronENST00000409501ENST00000475185UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000409032ENST00000450466UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000409032ENST00000383233UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000409032ENST00000542162UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000409032ENST00000399707UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000409032ENST00000475185UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000428048ENST00000450466UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000428048ENST00000383233UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000428048ENST00000542162UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000428048ENST00000399707UXS1chr2

106774514

-TMEM241chr18

20979611

-
intron-intronENST00000428048ENST00000475185UXS1chr2

106774514

-TMEM241chr18

20979611

-
5UTR-intronENST00000479621ENST00000450466UXS1chr2

106774514

-TMEM241chr18

20979611

-
5UTR-intronENST00000479621ENST00000383233UXS1chr2

106774514

-TMEM241chr18

20979611

-
5UTR-intronENST00000479621ENST00000542162UXS1chr2

106774514

-TMEM241chr18

20979611

-
5UTR-intronENST00000479621ENST00000399707UXS1chr2

106774514

-TMEM241chr18

20979611

-
5UTR-intronENST00000479621ENST00000475185UXS1chr2

106774514

-TMEM241chr18

20979611

-

Top

FusionProtFeatures for UXS1_TMEM241


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UXS1

Q8NBZ7

TMEM241

Q24JQ0

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis ofthe core tetrasaccharide in glycosaminoglycan biosynthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UXS1_TMEM241


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UXS1_TMEM241


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UXS1PEX19, HLA-B, SLC39A4, CBWD1, SPSB3, TSKU, NOP9, ANK3, XPO4, VPS8, FAM98A, HEATR3, VPS18, NUP160, NUP98, SAAL1, NUP85, RMND1, EIF2B3, MAPK3, DPEP1, HS2ST1, TTYH3, COX1, DDX1, LMBR1, NUP107, IPO7, EIF2B5, TPCN2, ATP2B2, TBC1D15, GEMIN4, PPP4R2, MPPE1, COG3TMEM241MDFI, ELAVL1, KRT40, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UXS1_TMEM241


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for UXS1_TMEM241


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUXS1C0376634Craniofacial Abnormalities1CTD_human