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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41311

FusionGeneSummary for UVRAG_TRIM29

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG_TRIM29
Fusion gene ID: 41311
HgeneTgene
Gene symbol

UVRAG

TRIM29

Gene ID

7405

23650

Gene nameUV radiation resistance associatedtripartite motif containing 29
SynonymsDHTX|VPS38|p63ATDC
Cytomap

11q13.5

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxytripartite motif-containing protein 29ataxia-telangiectasia group D-associated proteintripartite motif protein TRIM29
Modification date2018052320180522
UniProtAcc

Q9P2Y5

Q14134

Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000341846, ENST00000524816, 
ENST00000541857, ENST00000525887, 
ENST00000528870, ENST00000529044, 
Fusion gene scores* DoF score29 X 10 X 12=34805 X 7 X 3=105
# samples 297
** MAII scorelog2(29/3480*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UVRAG [Title/Abstract] AND TRIM29 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-23-1030-01AUVRAGchr11

75572825

+TRIM29chr11

119983184

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356136ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
Frame-shiftENST00000356136ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
Frame-shiftENST00000356136ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5CDS-5UTRENST00000356136ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5CDS-5UTRENST00000356136ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5CDS-5UTRENST00000356136ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5UTR-3CDSENST00000528420ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5UTR-3CDSENST00000528420ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5UTR-3CDSENST00000528420ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5UTR-5UTRENST00000528420ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5UTR-5UTRENST00000528420ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
5UTR-5UTRENST00000528420ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000533454ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000533454ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000533454ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000533454ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000533454ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000533454ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000531818ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000531818ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000531818ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000531818ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000531818ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000531818ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000532130ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000532130ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000532130ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000532130ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000532130ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000532130ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000539288ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000539288ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000539288ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000539288ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000539288ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000539288ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000525872ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000525872ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000525872ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000525872ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000525872ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000525872ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000538870ENST00000341846UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000538870ENST00000524816UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-3CDSENST00000538870ENST00000541857UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000538870ENST00000525887UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000538870ENST00000528870UVRAGchr11

75572825

+TRIM29chr11

119983184

-
intron-5UTRENST00000538870ENST00000529044UVRAGchr11

75572825

+TRIM29chr11

119983184

-

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FusionProtFeatures for UVRAG_TRIM29


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UVRAG

Q9P2Y5

TRIM29

Q14134

Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}. Plays a crucial role in the regulation of macrophageactivation in response to viral or bacterial infections within therespiratory tract. Mechanistically, TRIM29 interacts withIKBKG/NEMO in the lysosome where it induces its 'Lys-48'ubiquitination and subsequent degradation. In turn, the expressionof type I interferons and the production of proinflammatorycytokines are inhibited. Additionally, induces the 'Lys-48'ubiquitination of TMEM173/STING in a similar way, leading to itsdegradation. {ECO:0000269|PubMed:27695001,ECO:0000269|PubMed:29038422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75572825chr11:119983184ENST00000356136+315224_30590700Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75572825chr11:119983184ENST00000356136+31544_12890700DomainNote=C2
TgeneTRIM29chr11:75572825chr11:119983184ENST00000341846-79259_352568589Coiled coilOntology_term=ECO:0000255
TgeneTRIM29chr11:75572825chr11:119983184ENST00000341846-79220_260568589Zinc fingerB box-type


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FusionGeneSequence for UVRAG_TRIM29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UVRAG_ENST00000356136_chr11_75572825_+_TRIM29_ENST00000341846_chr11_119983184_-_111aa
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UVRAG_ENST00000356136_chr11_75572825_+_TRIM29_ENST00000341846_chr11_119983184_-_333nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC
CTGCATGTGGAGCTGCCGTCTCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAG
CTCCTTGATACCTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_UVRAG_ENST00000356136_chr11_75572825_+_TRIM29_ENST00000341846_chr11_119983184_-_1713nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGCG
GCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTT
GTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGTCTCACTACCGGCCATTCTACGTCAACAA
AGGCAACGGGATTGGGTCCAACGAAGCCCCATGAGCTCCTGGCGGAAGGAACGAGGCGCCACACCCCTGCTCTTCCTCCTGACCCTGCTG
CTCTTGCCTTCTAAGCTACTGTGCTTGTCTGGGTGGGAGGGAGCCTGGTCCTGCACCTGCCCTCTGCAGCCCTCTGCCAGCCTCTTGGGG
GCAGTTCCGGCCTCTCCGACTTCCCCACTGGCCACACTCCATTCAGACTCCTTTCCTGCCTTGTGACCTCAGATGGTCACCATCATTCCT
GTGCTCAGAGGCCAACCCATCACAGGGGTGAGATAGGTTGGGGCCTGCCCTAACCCGCCAGCCTCCTCCTCTCGGGCTGGATCTGGGGGC
TAGCAGTGAGTACCCGCATGGTATCAGCCTGCCTCTCCCGCCCACGCCCTGCTGTCTCCAGGCCTATAGACGTTTCTCTCCAAGGCCCTA
TCCCCCAATGTTGTCAGCAGATGCCTGGACAGCACAGCCACCCATCTCCCATTCACATGGCCCACCTCCTGCTTCCCAGAGGACTGGCCC
TACGTGCTCTCTCTCGTCCTACCTATCAATGCCCAGCATGGCAGAACCTGCAGCCCTTGGCCACTGCAGATGGAAACCTCTCAGTGTCTT
GACATCACCCTACCCAGGCGGTGGGTCTCCACCACAGCCACTTTGAGTCTGTGGTCCCTGGAGGGTGGCTTCTCCTGACTGGCAGGATGA
CCTTAGCCAAGATATTCCTCTGTTCCCTCTGCTGAGATAAAGAATTCCCTTAACATGATATAATCCACCCATGCAAATAGCTACTGGCCC
AGCTACCATTTACCATTTGCCTACAGAATTTCATTCAGTCTACACTTTGGCATTCTCTCTGGCGATGGAGTGTGGCTGGGCTGACCGCAA
AAGGTGCCTTACACACTGCCCCCACCCTCAGCCGTTGCCCCATCAGAGGCTGCCTCCTCCTTCTGATTACCCCCCATGTTGCATATCAGG
GTGCTCAAGGATTGGAGAGGAGACAAAACCAGGAGCAGCACAGTGGGGACATCTCCCGTCTCAACAGCCCCAGGCCTATGGGGGCTCTGG
AAGGATGGGCCAGCTTGCAGGGGTTGGGGAGGGAGACATCCAGCTTGGGCTTTCCCCTTTGGAATAAACCATTGGTCTGTCACTTCTCTT


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FusionGenePPI for UVRAG_TRIM29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UVRAGBECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226LTRIM29CRACR2A, MLH1, TSGA10, LZTS2, GCC1, GOLGA2, CEP70, FXR2, UBE2I, MAD1L1, JAKMIP2, MYO15B, FBF1, TRIM29, TRIM23, MID2, TRIM11, TRIM27, PARP1, DMRT1, GATA1, GTF2E1, HCLS1, PRICKLE3, POLR2D, POLR2E, SHOX2, SNAPC1, SP100, IKBKG, MED7, TAX1BP3, FBXL19, HDAC9, KAT5, SMAD9, TRIP6, CARD9, MOV10, NXF1, SUSD3, DDX19B, ZSCAN20, RBM24, XPO1, CAD, CLTA, DCTN1, SEC16A, SYNE1, RAB32, BOD1L1, SACS, PKN3, CHCHD3, ACTL8, KLHL13, TUBB, FOXD4, HIST1H1C, HIST1H2BC, HSPA1A, HIST1H4F, YBX3, HIST1H2AM, PHB2, RNF8, VIM, RPL13, RPS19, BASP1, HSPA5, RPS4X, RPS18, H1FX, SERBP1, RPS10, C1QBP, HMGA1, MARCKS, HNRNPU, RPL26, EEF1A1, RUVBL2, CDH1, MAPKAPK2, DVL2, FCF1, CDK15, FBXL4, CCNYL1, KIF3A, TBC1D22B, OAZ3, CCDC82, IL31RA, KIAA0907, CPLX3, ZMAT4, CDC34, UBE2E1, UBE2C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UVRAG_TRIM29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UVRAG_TRIM29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource