FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41297

FusionGeneSummary for UVRAG_MYEOV

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG_MYEOV
Fusion gene ID: 41297
HgeneTgene
Gene symbol

UVRAG

MYEOV

Gene ID

7405

26579

Gene nameUV radiation resistance associatedmyeloma overexpressed
SynonymsDHTX|VPS38|p63OCIM
Cytomap

11q13.5

11q13.3

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxymyeloma-overexpressed gene proteinmyeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)oncogene in multiple myeloma
Modification date2018052320180519
UniProtAcc

Q9P2Y5

Q96EZ4

Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000441339, ENST00000308946, 
ENST00000535407, ENST00000541137, 
Fusion gene scores* DoF score29 X 10 X 12=348013 X 4 X 7=364
# samples 2914
** MAII scorelog2(29/3480*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/364*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UVRAG [Title/Abstract] AND MYEOV [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0YF-01AUVRAGchr11

75572825

+MYEOVchr11

69181511

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356136ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
5CDS-intronENST00000356136ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
5CDS-intronENST00000356136ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
5CDS-3UTRENST00000356136ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+
5UTR-intronENST00000528420ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
5UTR-intronENST00000528420ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
5UTR-intronENST00000528420ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
5UTR-3UTRENST00000528420ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000533454ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000533454ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000533454ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-3UTRENST00000533454ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000531818ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000531818ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000531818ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-3UTRENST00000531818ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000532130ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000532130ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000532130ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-3UTRENST00000532130ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000539288ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000539288ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000539288ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-3UTRENST00000539288ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000525872ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000525872ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000525872ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-3UTRENST00000525872ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000538870ENST00000441339UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000538870ENST00000308946UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-intronENST00000538870ENST00000535407UVRAGchr11

75572825

+MYEOVchr11

69181511

+
intron-3UTRENST00000538870ENST00000541137UVRAGchr11

75572825

+MYEOVchr11

69181511

+

Top

FusionProtFeatures for UVRAG_MYEOV


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UVRAG

Q9P2Y5

MYEOV

Q96EZ4

Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UVRAG_MYEOV


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UVRAG_MYEOV


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UVRAGBECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226LMYEOVPRTFDC1, CNN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UVRAG_MYEOV


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for UVRAG_MYEOV


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource