	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 41283

FusionGeneSummary for UTY_UTY

Fusion gene summary

Fusion gene information	Fusion gene name: UTY_UTY
	Fusion gene ID: 41283
		Hgene	Tgene
	Gene symbol	UTY	UTY
	Gene ID	7404	7404
	Gene name	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
	Synonyms	KDM6AL\|KDM6C\|UTY1	KDM6AL\|KDM6C\|UTY1
	Cytomap	Yq11.221	Yq11.221
	Type of gene	protein-coding	protein-coding
	Description	histone demethylase UTYubiquitous TPR motif protein UTYubiquitously transcribed TPR gene on Y chromosomeubiquitously transcribed tetratricopeptide repeat gene, Y chromosomeubiquitously transcribed tetratricopeptide repeat gene, Y-linkedubiquitously-t	histone demethylase UTYubiquitous TPR motif protein UTYubiquitously transcribed TPR gene on Y chromosomeubiquitously transcribed tetratricopeptide repeat gene, Y chromosomeubiquitously transcribed tetratricopeptide repeat gene, Y-linkedubiquitously-t
	Modification date	20180523	20180523
	UniProtAcc	O14607	O14607
	Ensembl transtripts involved in fusion gene	ENST00000331397, ENST00000382896, ENST00000537580, ENST00000362096, ENST00000329134, ENST00000538878, ENST00000540140, ENST00000545955, ENST00000474365, ENST00000382893,	ENST00000331397, ENST00000382896, ENST00000537580, ENST00000362096, ENST00000329134, ENST00000538878, ENST00000540140, ENST00000545955, ENST00000474365, ENST00000382893,
Fusion gene scores	* DoF score	2 X 2 X 1=4	2 X 2 X 1=4
	# samples	2	2
	** MAII score	log2(2/4*10)=2.32192809488736	log2(2/4*10)=2.32192809488736
Context	PubMed: UTY [Title/Abstract] AND UTY [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA744810	UTY	chrY	15359372	+	UTY	chrY	15358063	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000331397	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000331397	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382896	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000537580	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000362096	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000329134	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000538878	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000540140	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000545955	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000474365	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000331397	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000382896	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000537580	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000362096	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000329134	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000538878	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000540140	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000545955	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000474365	UTY	chrY	15359372	+	UTY	chrY	15358063	+
intron-intron	ENST00000382893	ENST00000382893	UTY	chrY	15359372	+	UTY	chrY	15358063	+

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FusionProtFeatures for UTY_UTY

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UTY O14607	UTY O14607
Male-specific histone demethylase that catalyzestrimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Hasrelatively low lysine demethylase activity.{ECO:0000269\|PubMed:24798337}.	Male-specific histone demethylase that catalyzestrimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Hasrelatively low lysine demethylase activity.{ECO:0000269\|PubMed:24798337}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for UTY_UTY

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UTY_UTY

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for UTY_UTY

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for UTY_UTY

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 41283

FusionGeneSummary for UTY_UTY

FusionProtFeatures for UTY_UTY

FusionGeneSequence for UTY_UTY

FusionGenePPI for UTY_UTY

RelatedDrugs for UTY_UTY

RelatedDiseases for UTY_UTY