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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4128

FusionGeneSummary for BGN_ADAMTS1

check button Fusion gene summary
Fusion gene informationFusion gene name: BGN_ADAMTS1
Fusion gene ID: 4128
HgeneTgene
Gene symbol

BGN

ADAMTS1

Gene ID

633

9510

Gene namebiglycanADAM metallopeptidase with thrombospondin type 1 motif 1
SynonymsDSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1AC3-C5|METH1
Cytomap

Xq28

21q21.3

Type of geneprotein-codingprotein-coding
Descriptionbiglycanbone/cartilage proteoglycan-Idermatan sulphate proteoglycan Ismall leucine-rich protein 1AA disintegrin and metalloproteinase with thrombospondin motifs 1ADAM-TS 1ADAM-TS1ADAMTS-1METH-1a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1human metalloproteinase with thrombospondin type 1 motifs
Modification date2018052220180519
UniProtAcc

P21810

Q9UHI8

Ensembl transtripts involved in fusion geneENST00000331595, ENST00000480756, 
ENST00000284984, 
Fusion gene scores* DoF score15 X 7 X 11=11552 X 2 X 1=4
# samples 173
** MAII scorelog2(17/1155*10)=-2.76428620016572
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/4*10)=2.90689059560852
Context

PubMed: BGN [Title/Abstract] AND ADAMTS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF437005BGNchrX

152774808

-ADAMTS1chr21

28209980

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000331595ENST00000284984BGNchrX

152774808

-ADAMTS1chr21

28209980

+
3UTR-3CDSENST00000480756ENST00000284984BGNchrX

152774808

-ADAMTS1chr21

28209980

+

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FusionProtFeatures for BGN_ADAMTS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BGN

P21810

ADAMTS1

Q9UHI8

May be involved in collagen fiber assembly.{ECO:0000250}. Cleaves aggrecan, a cartilage proteoglycan, at the'1938-Glu-|-Leu-1939' site (within the chondroitin sulfateattachment domain), and may be involved in its turnover (Bysimilarity). Has angiogenic inhibitor activity. Activemetalloprotease, which may be associated with various inflammatoryprocesses as well as development of cancer cachexia. May play acritical role in follicular rupture. {ECO:0000250,ECO:0000269|PubMed:10438512}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BGN_ADAMTS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BGN_ADAMTS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BGN_ADAMTS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BGN_ADAMTS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBGNC0003873Rheumatoid Arthritis1CTD_human
HgeneBGNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneBGNC1848097Spondyloepimetaphyseal Dysplasia, X-Linked1ORPHANET;UNIPROT
TgeneADAMTS1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneADAMTS1C0027626Neoplasm Invasiveness1CTD_human
TgeneADAMTS1C1458155Mammary Neoplasms1CTD_human
TgeneADAMTS1C2239176Liver carcinoma1CTD_human