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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4126

FusionGeneSummary for BFAR_BFAR

check button Fusion gene summary
Fusion gene informationFusion gene name: BFAR_BFAR
Fusion gene ID: 4126
HgeneTgene
Gene symbol

BFAR

BFAR

Gene ID

51283

51283

Gene namebifunctional apoptosis regulatorbifunctional apoptosis regulator
SynonymsBAR|RNF47BAR|RNF47
Cytomap

16p13.12

16p13.12

Type of geneprotein-codingprotein-coding
Descriptionbifunctional apoptosis regulatorRING finger protein 47bifunctional apoptosis inhibitorbifunctional apoptosis regulatorRING finger protein 47bifunctional apoptosis inhibitor
Modification date2018052320180523
UniProtAcc

Q9NZS9

Q9NZS9

Ensembl transtripts involved in fusion geneENST00000261658, ENST00000563971, 
ENST00000426842, ENST00000563082, 
ENST00000261658, ENST00000563971, 
ENST00000426842, ENST00000563082, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 3 X 3=36
# samples 35
** MAII scorelog2(3/8*10)=1.90689059560852log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BFAR [Title/Abstract] AND BFAR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBFAR

GO:0000209

protein polyubiquitination

21068390

HgeneBFAR

GO:0006511

ubiquitin-dependent protein catabolic process

21068390

HgeneBFAR

GO:0043066

negative regulation of apoptotic process

10716992

HgeneBFAR

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21068390

HgeneBFAR

GO:0051865

protein autoubiquitination

21068390

HgeneBFAR

GO:0070534

protein K63-linked ubiquitination

21068390

HgeneBFAR

GO:0070936

protein K48-linked ubiquitination

21068390

TgeneBFAR

GO:0000209

protein polyubiquitination

21068390

TgeneBFAR

GO:0006511

ubiquitin-dependent protein catabolic process

21068390

TgeneBFAR

GO:0043066

negative regulation of apoptotic process

10716992

TgeneBFAR

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21068390

TgeneBFAR

GO:0051865

protein autoubiquitination

21068390

TgeneBFAR

GO:0070534

protein K63-linked ubiquitination

21068390

TgeneBFAR

GO:0070936

protein K48-linked ubiquitination

21068390


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CR746500BFARchr16

14748960

-BFARchr16

14749017

+
ChiTaRS3.1BQ424556BFARchr16

14748960

-BFARchr16

14749017

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261658ENST00000261658BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000261658ENST00000563971BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000261658ENST00000426842BFARchr16

14748960

-BFARchr16

14749017

+
5CDS-intronENST00000261658ENST00000563082BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000563971ENST00000261658BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000563971ENST00000563971BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000563971ENST00000426842BFARchr16

14748960

-BFARchr16

14749017

+
5CDS-intronENST00000563971ENST00000563082BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000426842ENST00000261658BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000426842ENST00000563971BFARchr16

14748960

-BFARchr16

14749017

+
Frame-shiftENST00000426842ENST00000426842BFARchr16

14748960

-BFARchr16

14749017

+
5CDS-intronENST00000426842ENST00000563082BFARchr16

14748960

-BFARchr16

14749017

+
intron-3CDSENST00000563082ENST00000261658BFARchr16

14748960

-BFARchr16

14749017

+
intron-3CDSENST00000563082ENST00000563971BFARchr16

14748960

-BFARchr16

14749017

+
intron-3CDSENST00000563082ENST00000426842BFARchr16

14748960

-BFARchr16

14749017

+
intron-intronENST00000563082ENST00000563082BFARchr16

14748960

-BFARchr16

14749017

+

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FusionProtFeatures for BFAR_BFAR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BFAR

Q9NZS9

BFAR

Q9NZS9

Apoptosis regulator. Has anti-apoptotic activity, bothfor apoptosis triggered via death-receptors and via mitochondrialfactors. {ECO:0000269|PubMed:14502241}. Apoptosis regulator. Has anti-apoptotic activity, bothfor apoptosis triggered via death-receptors and via mitochondrialfactors. {ECO:0000269|PubMed:14502241}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BFAR_BFAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BFAR_BFAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BFAR_BFAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BFAR_BFAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource