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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41203

FusionGeneSummary for USP6_ELOF1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP6_ELOF1
Fusion gene ID: 41203
HgeneTgene
Gene symbol

USP6

ELOF1

Gene ID

9098

84337

Gene nameubiquitin specific peptidase 6elongation factor 1 homolog
SynonymsHRP1|TRE17|TRE2|TRESMCR|Tre-2|USP6-shortELF1
Cytomap

17p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 6TBC1D3 and USP32 fusiondeubiquitinating enzyme 6hyperpolymorphic gene 1proto-oncogene TRE-2ubiquitin specific peptidase 6 (Tre-2 oncogene)ubiquitin specific protease 6 (Tre-2 oncogene)ubiquitin thioesterase 6transcription elongation factor 1 homologELF1 homolog, elongation factor 1elongation factor 1 homolog (ELF1, S. cerevisiae)
Modification date2018052320180529
UniProtAcc

P35125

P60002

Ensembl transtripts involved in fusion geneENST00000332776, ENST00000574788, 
ENST00000304328, ENST00000250066, 
ENST00000572429, 
ENST00000586683, 
ENST00000252445, ENST00000587806, 
ENST00000589171, ENST00000591674, 
ENST00000586120, ENST00000590700, 
ENST00000591912, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 3 X 5=105
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP6 [Title/Abstract] AND ELOF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP6

GO:0016579

protein deubiquitination

16127172

HgeneUSP6

GO:0060627

regulation of vesicle-mediated transport

15509780


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A1J1-01AUSP6chr17

5052062

+ELOF1chr19

11665180

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000332776ENST00000586683USP6chr17

5052062

+ELOF1chr19

11665180

-
3UTR-5UTRENST00000332776ENST00000252445USP6chr17

5052062

+ELOF1chr19

11665180

-
3UTR-5UTRENST00000332776ENST00000587806USP6chr17

5052062

+ELOF1chr19

11665180

-
3UTR-5UTRENST00000332776ENST00000589171USP6chr17

5052062

+ELOF1chr19

11665180

-
3UTR-5UTRENST00000332776ENST00000591674USP6chr17

5052062

+ELOF1chr19

11665180

-
3UTR-5UTRENST00000332776ENST00000586120USP6chr17

5052062

+ELOF1chr19

11665180

-
3UTR-5UTRENST00000332776ENST00000590700USP6chr17

5052062

+ELOF1chr19

11665180

-
3UTR-5UTRENST00000332776ENST00000591912USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000586683USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000252445USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000587806USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000589171USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000591674USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000586120USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000590700USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000574788ENST00000591912USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000586683USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000252445USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000587806USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000589171USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000591674USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000586120USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000590700USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000304328ENST00000591912USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000586683USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000252445USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000587806USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000589171USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000591674USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000586120USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000590700USP6chr17

5052062

+ELOF1chr19

11665180

-
5CDS-5UTRENST00000250066ENST00000591912USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000586683USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000252445USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000587806USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000589171USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000591674USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000586120USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000590700USP6chr17

5052062

+ELOF1chr19

11665180

-
intron-5UTRENST00000572429ENST00000591912USP6chr17

5052062

+ELOF1chr19

11665180

-

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FusionProtFeatures for USP6_ELOF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP6

P35125

ELOF1

P60002

Deubiquitinase with an ATP-independent isopeptidaseactivity, cleaving at the C-terminus of the ubiquitin moiety.Catalyzes its own deubiquitination. In vitro, isoform 2, but notisoform 3, shows deubiquitinating activity. Promotes plasmamembrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiatetumorigenesis by inducing the production of matrixmetalloproteinases following NF-kappa-B activation.{ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172,ECO:0000269|PubMed:20418905}. Transcription elongation factor implicated in themaintenance of proper chromatin structure in actively transcribedregions. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP6_ELOF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP6_ELOF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP6USP32, CALM2, RAC1, CDC42, RAB33B, ARF6, MYL2, ANKRD44, ATXN7L3, APP, MDFI, EXOSC8, KRAS, JUNELOF1C5orf22, ATP5C1, MAPK6, CHMP6, KDM1A, SUV39H1, AURKA, SMURF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP6_ELOF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP6_ELOF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource